Injectable composition comprising hyaluronidase for removing local fat

An injectable composition, hyaluronidase technology, applied in the field of injectable composition, can solve the problem of unsatisfactory effect

Pending Publication Date: 2020-10-27
孙维那
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] Although the lipolytic injectable composition disclosed in the above patent documents has some efficacy in removing fat, its effect is still not satisfactory enough

Method used

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  • Injectable composition comprising hyaluronidase for removing local fat
  • Injectable composition comprising hyaluronidase for removing local fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0097] Preparation of injectable composition

[0098] The composition and composition ratio of the injectable composition are described in Table 1. The composition containing hyaluronidase in an amount of less than 300 IU is designated as Comparative Example 1, and the composition containing hyaluronidase in an amount of more than 600 IU is designated as Comparative Example 1. Designated as Comparative Example 2, a composition containing 300 IU of hyaluronidase was designated as Comparative Example 3, and a composition according to the present invention was designated as an Example.

[0099] [Table 1]

[0100] ingredient Comparative example 1 Comparative example 2 Comparative example 3 Example Hyaluronidase25,000IU65,000IU30,000IU30,000IU Lidocaine 21.0mg 21.0mg 21.0mg 21.0mg Pheniramine 1.2mg 1.2mg 1.2mg 1.2mg L-carnitine 66.0mg 66.0mg 66.0mg 66.0mg Vitamin C 60.0mg 60.0mg 60.0mg 60.0mg Adrenaline 5.0mg Choline alfoscerate 40.0mg Sodium bicarbonate 20.0mg Salt solution ...

experiment Embodiment 1

[0103] Lipolysis of the injectable composition of the present invention

[0104] The changes in waist circumference after administration of the injectable compositions of the Examples and the injectable compositions of Comparative Examples 1 to 3 and the changes in waist circumference after the endomology treatment were measured and shown in Table 2.

[0105] The treated subjects were a total of 40 abdominal obese patients (20 males, 20 females) with a BMI of 25 or greater selected from adult outpatients aged 20 years or older.

[0106] In the abdominal area between the ribs and the pubic bone, 50 points were injected with 1 cc of the injectable composition, and the 50 points were arranged so that they were 1 cm apart from the navel. Repeat the injection every week for four weeks, moving the injection point each time. The reduction in waist circumference was measured 1 week after the completion of the treatment, and then measured again 1 month after the completion of the treatment. ...

experiment Embodiment 2

[0117] Evaluation of the side effects of the injectable composition of the present invention

[0118] The injectable compositions of the Examples and the injectable compositions of Comparative Examples 1-3 were administered in the same manner as in Experimental Example 1. The side effects observed in each patient in the clinical trial are shown in Table 3.

[0119] [table 3]

[0120]

[0121] *Skin elasticity is determined by tactile evaluation using a 5-point scale: 1: very poor; 2: poor; 3: fair; 4: good; 5: very good.

[0122] As shown in Table 3, compared with Comparative Examples 1 to 3, the injectable composition according to the examples of the present invention showed significantly reduced allergic redness, swelling, itching and pain.

[0123] These effects are believed to be due to the use of local anesthetics, antihistamines, epinephrine, methacholine and sodium bicarbonate, and low-dose hyaluronidase.

[0124] Overall, it is believed that the above-mentioned effects are due to...

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Abstract

The present invention relates to an injectable composition for removing local fat comprising 300 to 600 IU of hyaluronidase and, based on the weight of the total composition, 0.08 to 0.4% by weight oflocal anesthetic, 0.01 to 0.02% by weight of antihistamine, 0.01 to 4.0% by weight of lipolysis stimulator, 0.01 to 0.08% by weight of the neurotransmitter, 0.01 to 4.0% by weight of the lipolytic agent, 0.05 to 0.3% by weight of reagent for pH adjustment and as allergies and acidosis treatment, and 0.1 to 2.0% by weight of collagen production stimulator, with the remainder being saline solution.According to the present invention, reduction in local fat tissues is promoted to ameliorate obesity and keep weight loss and a body shape. In addition, side effects or imbalance in skin can be prevented by evenly removing fat, and generation of collagen is promoted to give an effect of lifting where skin elasticity is kept.

Description

[0001] Cross references to related applications [0002] This application claims priority for Korean Patent Application No. 10-2019-0044869 filed on April 17, 2019, the entire disclosure of which is incorporated herein by reference. Technical field [0003] The present invention relates to an injectable composition for local fat removal. More specifically, the present invention relates to a drug containing hyaluronidase and one or more local anesthetics, antihistamines, neurotransmitters, lipolysis agents, lipolysis stimulators, pH regulators and collagen production stimulators. Injection composition. [0004] The composition of the present invention helps to burn excess fat in the body, achieve the effect of aerobic exercise, and the subsequent excretion of metabolites leads to weight loss and improvement of body shape. The composition of the present invention also improves the basal metabolic rate, thereby enhancing the effects of exercise and diet, and stimulating the reduction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/08A61P3/04A61K31/137A61K31/167A61K31/205A61K31/375A61K31/4402A61K31/685A61K33/00
CPCA61K38/47C12Y302/01035A61K31/167A61K31/4402A61K31/205A61K31/137A61K31/685A61K33/00A61K31/375A61K9/0019A61K9/08A61P3/04A61K2300/00A61K47/02A61K8/66A61Q19/06A61K8/411A61K8/55A61K2800/91
Inventor 孙维那
Owner 孙维那
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