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Medicine for treating vitiligo and application

A kind of vitiligo and drug technology, applied in the field of vitiligo, can solve the problems of imbalance of protective effect, achieve the effect of promoting proliferation, reducing depigmentation, and inhibiting occurrence and development

Pending Publication Date: 2020-11-03
PEOPLES HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION
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Problems solved by technology

In addition, the researchers found that down-regulation of miR-29b can increase the expression of multiple ECM genes under chronic oxidative stress conditions, and the imbalance between the activation of oxidative stress-induced ECM gene products and the protective effect of miR-29b may Associated with elevated intraocular pressure in glaucoma

Method used

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  • Medicine for treating vitiligo and application
  • Medicine for treating vitiligo and application
  • Medicine for treating vitiligo and application

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Experimental program
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Effect test

Embodiment 1

[0029] 1 Materials and methods

[0030] 1.1 Screening of differential miRNAs in patients with vitiligo

[0031] The plasma of 12 normal people and 12 patients with vitiligo in the stable stage were collected, and the differentially expressed miRNAs in the aforementioned plasma were detected using the AgilentHuman miRNA v 21.0 chip. differentially expressed microRNAs. The screening criteria are: fold-change≧1.5, and P<0.05.

[0032] 1.2 qRT-PCR detection of relative expression of miR-223-3p in plasma of patients with vitiligo

[0033]1.3 miR-223-3p to H 2 o 2 Effects of inducing human melanocyte injury

[0034] 1.3.1 Melanocyte cell culture

[0035] Immediately after the circumcision of healthy males, put them into the D-Hanks solution containing 100U / ml blue-chain double antibody and 5ug / ml amphotericin B for 15 minutes. Take out the foreskin and put it in a petri dish, and wash it three times repeatedly with D-Hanks solution containing 100 U / ml blue-chain double antibo...

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Abstract

The invention belongs to the technical field of vitiligo, and discloses a medicine for treating leucoderma and an application. The medicine for treating vitiligo comprises an miR-223-3p inhibiting factor and a pharmaceutically acceptable carrier. The medicine has the advantages that by inhibiting the combination of the miR-223-3p and a target gene thereof, the proliferation of human epidermal melanocytes is promoted, depigmentation at the skin lesion caused by vitiligo is reduced, and the effect of inhibiting the occurrence and development of vitiligo is achieved. Besides, the invention also provides an application of the miR-223-3p, reveals a signal path of the miR-223-3p for treating vitiligo, and also provides a new idea for clinical pharmacy.

Description

technical field [0001] The invention belongs to the technical field of vitiligo, in particular to a medicine for treating vitiligo and its application. Background technique [0002] Vitiligo (Vitiligo) is a common depigmentation disease, clinically characterized by the destruction of melanocytes, loss of melanosomes and white spots on the skin, both adults and children can suffer from it, and the worldwide incidence rate is 0.5 %-2%. Vitiligo affects the appearance and easily causes mental disorders such as anxiety and depression. Clinically, it is often accompanied by various autoimmune diseases such as hyperthyroidism, diabetes and alopecia areata. It can also induce diseases such as psoriasis, malignant tumors and bronchial asthma. Vitiligo is stubborn and easy to relapse, and there is no effective treatment at present. Depigmentation in vitiligo lesions is mainly caused by the absence or reduction of local melanocytes. In recent years, a large number of studies have sh...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P17/00
CPCA61K45/00A61P17/00
Inventor 胡雯康晓静雷子闲王红娟张祥月关猛猛张景展刘新梅王鹏赵娟李婷婷
Owner PEOPLES HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION
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