Periodontal regeneration material with immune regulation function and preparation method of periodontal regeneration material

Abstract

The present invention provides a periodontal regeneration material with an immune regulation function. The periodontal regeneration material with the immune regulation function comprises bio-derived calcium apatite particles and macrophage polarization inducing factors, and the macrophage polarization inducing factors are loaded on the bio-derived calcium apatite particles. The present invention also proposes a preparation method of the periodontal regeneration material with the immune regulation function. The preparation method comprises the following steps: step one, preparing a bio-derivedcalcium apatite material and screening loads with a suitable particle size for inducing factors for subsequent polarization of macrophages; and step two, coating polydopamine on surfaces of the prepared bio-derived calcium apatite and then realizing loading and slow release of the inducing factors for the polarization of the macrophages by a soaking method. The inducing factors for the polarization of the macrophages (such as cytokines and lipopolysaccharides) are loaded on the bio-derived calcium apatite material. The present invention aims to develop a new type of the periodontal immune regeneration material which can stabilize periodontal defect spaces and also has an immune regulation function, so as to realize regeneration of periodontal tissues.

Description

technical field [0001] The invention belongs to the field of new medical materials, and in particular relates to a periodontal regeneration material with immune regulation function and a preparation method thereof. Background technique [0002] Periodontal tissue defect is a common disease in the oral and maxillofacial region, often caused by severe periodontitis, tumor, trauma, etc., which seriously affects the oral and jaw function, facial appearance and quality of life of patients. The periodontal tissue includes alveolar bone, cementum, and periodontal ligament, which has a complex structure and various layers, and contains soft and hard tissue structures. Its restoration needs to achieve multiple physiological structures of "alveolar bone-periodontal ligament-cementum". Tissue regeneration is an important and difficult point in the field of oral cavity research. At present, guided tissue regeneration (GTR) is widely used in the clinical treatment of periodontal defects,...

AI Technical Summary

Problems solved by technology

[0005] However, the direct implantation of macrophage polarization-inducing factors in the periodontal defect area has the following problems: (1) It cannot maintain a stable regeneration space and adapt to the defect shape

Direct implantation of macrophage polarization-inducing factor can easily lead to too high local initial concentration, which is not conducive to regeneration, and short-term rapid release cannot achieve the purpose of long-term regulation of the local immune microenvironment of the defect to promote the regeneration of multiple periodontal tissues, and there is a time limit and the problem of insufficient dose-response

Images