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Traditional Chinese medicine composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as poor compliance, lack of Yin-nourishing and Qi-tonifying medicines

Active Publication Date: 2020-11-13
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The compatibility of Qingfei Mixture is mainly attacking, clearing, and purging, and it lacks Yin-nourishing and Qi-tonifying medicines. The low immunity of modern people is usually due to Qi and blood problems in the sub-health state, so it is not suitable for patients with low immunity, especially in the later stage. fibrosis patients
At the same time, Qingfei Mixture is prepared by decocting, and the patient's compliance with taking it is poor.

Method used

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  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation of Qingfei Oral Liquid (water extraction)

[0037] Weigh 12 g of Zhebei, 15 g of Hedyotis diffusa, 15 g of Solanum nigrum, 5 g of Chonglou, 15 g of Scutellaria barbata, 12 g of Adenophora, 8 g of Prunella vulgaris, 15 g of Lily, 15 g of Radix Polygonatum, and place in Add 8 times the amount (896 ml) of water to the distillation bottle, soak for 1 hour, extract at 180°C for 1.5 hours under constant temperature reflux, and filter to obtain the filtrate. The filtrate was combined and the two filtrates were rotary evaporated to a volume of 896 ml.

Embodiment 2

[0038] Example 2: Qingfei Oral Liquid (alcohol extraction)

[0039] Weigh 12 g of Zhebei, 15 g of Hedyotis diffusa, 15 g of Solanum nigrum, 5 g of Chonglou, 15 g of Scutellaria barbata, 12 g of Adenophora, 8 g of Prunella vulgaris, 15 g of Lily, 15 g of Radix Polygonatum, and place in Add 8 times the amount (896 ml) of 50% alcohol to the distillation bottle, soak for 1 hour, reflux at 180°C for 1.5 hours, filter to obtain the filtrate, add 8 times the amount of 50% alcohol to the dregs, and reflux for the second time at 180°C After 1.5 hours, the filtrate was obtained by filtration, and the two filtrates were combined and rotary evaporated to a volume of 896 ml.

Embodiment 3

[0040]Embodiment 3: pharmacological test

[0041] 1) Experimental animals

[0042] A. Rats: 108 Specific pathogen Free (SPF) grade male CD (SD) rats (Beijing Weitong Lihua Co., Ltd., animal certificate number: 11400700359419), in the SPF grade animal barrier system, The experimental rats were raised in stainless steel wire cages (500×350×200 mm), 6 rats per cage, and the quarantine period was 5-7 days. Healthy rats were selected for the experiment.

[0043] B. Model establishment: except the normal control group. Rats were intravenously anesthetized with pentobarbital, fixed on the rat board in a supine position, the neck hair was cut off, and the skin was disinfected with 75% alcohol + povidone iodine. The neck incision was separated layer by layer until the trachea was exposed. Under direct vision, a 1 ml syringe was used to puncture the space between the two cartilage rings, keeping the needle in the same direction as the airway, and a one-time rapid injection of bleomyci...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating lung diseases and pharmaceutical application thereof. The traditional Chinese medicine composition comprises black nightshade herb, lily, common selfheal fruit-spike, thunberbg fritillary bulb, paris root, rhizoma polygonati, the root of straight ladybell, barbated skullcup herband oldenlandia diffusa. A water extraction or alcohol extraction method is adopted for preparation. The composition has a treatment effect on lung diseases, especially lung diseases related to oxidative / antioxidant imbalance or inflammatoryresponse, including HYP or MDA level increase, TGF-beta abnormal expression, SOD and GSH level decrease and the like. Experiments prove that the composition can improve lung tissues of rats, and theanti-fibrosis effect of the composition is superior to that of lung clearing mixtures and pirfenidone.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an active component of traditional Chinese medicine and its application in preparing medicine for treating lung diseases. Background technique [0002] Respiratory system diseases are mainly acute inflammation of the nose and pharynx, mostly caused by viruses, or allergies to smoking, mining, industrial waste gas, etc., which can lead to tracheobronchial inflammation and lung diseases, and in severe cases, pulmonary fibrosis, pulmonary edema, pulmonary embolism, etc. . With the development of urbanization, the population density is increasing day by day, and the personal work pressure continues to increase. Many people are in a state of sub-health and low immunity. The air pollution caused by industrial development makes respiratory diseases more and more common and serious. Especially with the epidemic pneumonia bacterial virus, the lung immune system is the first to be attacked. [0003...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P11/00A61P39/06
CPCA61K36/23A61K36/34A61K36/342A61K36/536A61K36/539A61K36/748A61K36/81A61K36/896A61K36/8966A61K36/8967A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61P11/00A61P39/06A61K2300/00
Inventor 黄萍李清林张轶雯刘宇佳郑小卫潘宗富邹小舟
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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