Intracranial stimulation and recording system and preparation method thereof

A recording system and laser technology, applied in the field of neuroscience, can solve the problems of experimental body damage, easy to cause neuroinflammation, brain tissue damage, etc., to reduce neuroinflammation, improve mechanical compliance, and avoid injury.

Pending Publication Date: 2020-11-17
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the heating of the LED chip in the first technical solution will cause damage to the brain tissue; the second technical solution is mostly processed on a hard silicon substrate, and the hard silicon substrate probe and the Young's modulus of the brain tissue The difference is huge. If the device is implanted in the body for a long time, it is easy to cause neuroinflammation, which will cause damage to the experimental body.

Method used

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  • Intracranial stimulation and recording system and preparation method thereof
  • Intracranial stimulation and recording system and preparation method thereof
  • Intracranial stimulation and recording system and preparation method thereof

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Embodiment 1

[0046] This embodiment provides an intracranial stimulation recording system, such as figure 1 As shown, the intracranial stimulation recording system includes a flexible optical fiber 1 , a flexible deep brain electrode 2 and a laser 3 . The flexible deep brain electrode 2 is fixed to the front end of the flexible optical fiber 1 by a clamp 4, and the flexible part of the flexible deep brain electrode 2 is naturally drooped by gravity, and is attached to the flexible optical fiber due to capillary tension. 1 surface. The laser 3 is connected to the rear end of the flexible optical fiber 1 as a light source for light stimulation.

[0047] Such as Figure 2hAs shown, the flexible deep brain electrode includes a substrate layer 5 , a metal wiring layer 6 , an insulating layer 7 , a metal electrode layer 8 and an encapsulation layer 9 arranged from bottom to top. Preferably, the substrate layer 5 is made of silk protein for supporting the metal wiring layer 6 , the insulating ...

Embodiment 2

[0049] This embodiment provides a method for preparing the above-mentioned intracranial stimulation recording system, the method comprising the following steps:

[0050] S1: Prepare a clean substrate 10 for use.

[0051] Preferably, the substrate 10 is a single-polished silicon wafer with a thickness of 300-500 μm (for example, 450 μm), and the single-polished silicon wafer is cleaned for later use (see Figure 2a ).

[0052] S2: Prepare a nickel sacrificial layer 11 on the substrate 10 prepared in step S1.

[0053] Specifically, the photoresist (such as SU-8 photoresist) is patterned by photolithography on the substrate 10 prepared in step S1, and a layer with a thickness of 50-150nm (such as 100nm) metallic nickel, the metallic nickel is carried out lift-off process patterning to obtain nickel sacrificial layer 11, and described nickel sacrificial layer 11 is used for subsequently releasing flexible deep brain electrode from described substrate 10 (see Figure 2b ).

[0...

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Abstract

The invention discloses an intracranial stimulation and recording system. The intracranial stimulation and recording system comprises a flexible optical fibre, a laser and a flexible deep brain electrode; the flexible optical fibre is connected with the laser; and the flexible deep brain electrode is fixed to the flexible optical fibre through a clamp. Correspondingly, the invention further discloses a method for preparing the intracranial stimulation and recording system. According to the invention, the flexible deep brain electrode is attached to the surface of the flexible optical fibre; the laser serves as a light source, so that the functions of optical pulse nerve stimulation and nerve electrophysiological signal acquisition can be integrated; meanwhile, optogenetic excitation and inhibition are achieved; damage to brain tissues due to heating of an LED chip when the LED chip serves as the light source can be avoided; silk protein is adopted as main materials of a substrate layer, an insulating layer and a packaging layer of the flexible deep brain electrode; in combination with a flexible optical fibre material, the mechanical compliance of an implanted device to brain tissues can be greatly improved; therefore, neuroinflammation caused by long-term in-vivo stimulation and recording after the device is implanted is reduced; and long-term in-vivo stimulation and recordingare achieved.

Description

technical field [0001] The invention relates to the technical field of neuroscience, in particular to an intracranial stimulation recording system and a preparation method thereof. Background technique [0002] The brain is the most complex and advanced biological organ in the known universe, and neurons, as the basic structure of the brain, are responsible for transmitting neural information. Neurons with different properties and functions form neural circuits through various forms of complex connections. Neural circuits are the bridge between molecular and cellular functions and overall behavioral functions. The study of specific functional neural circuits is conducive to understanding the formation and modification of neural circuits, information encoding and its relationship with behavior, etc., so as to gain a deeper understanding of How the brain works. [0003] Neuromodulation is an effective means of studying neural circuits. Common neuromodulation methods include...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36A61N1/05A61N5/06
CPCA61N1/0534A61N1/3606A61N5/0601A61N5/067
Inventor 陶虎王馨儿魏晓玲周志涛
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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