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Fluorescent probe for high-selectivity recognition of phosphate, preparation method and application

A fluorescent probe and phosphate technology, applied in the field of fluorescent probes, can solve the problems of low sensitivity, unsuitable for phosphate detection and measurement, poor selectivity, etc., and achieve the effects of good water solubility, sensitive response and high selectivity

Active Publication Date: 2020-11-17
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems with the phosphate fluorescent probes reported so far, including poor selectivity, low sensitivity, and unsuitability for the detection and measurement of phosphate in aqueous environments.

Method used

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  • Fluorescent probe for high-selectivity recognition of phosphate, preparation method and application
  • Fluorescent probe for high-selectivity recognition of phosphate, preparation method and application
  • Fluorescent probe for high-selectivity recognition of phosphate, preparation method and application

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Experimental program
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Embodiment 1

[0047] Embodiment 1: the synthesis of formula (II) compound

[0048] The synthetic design route is as follows:

[0049]

Embodiment approach 1

[0050] Embodiment 1: Dissolve 288 mg (1 mmol) of 4-phenyl-2-trifluoromethyl-7-aminoquinoline in dichloromethane, add N,N-diisopropylethylamine (DIPEA) (2 mmol), Then 122 mg (1 mmol) of methyl oxalyl chloride was added dropwise to the above mixed solution, then reacted at room temperature for 8 h, and filtered with suction to obtain 220 mg of a pure white solid with a yield of 59%.

Embodiment approach 2

[0051] Embodiment 2: Dissolve 288mg (1mmol) 4-phenyl-2-trifluoromethyl-7-aminoquinoline in dichloromethane, add N,N-diisopropylethylamine (DIPEA), and then dissolve 183mg (1.5 mmol) of methyl oxalyl chloride was added dropwise to the above mixed solution, then reacted at room temperature for 8 h, and filtered with suction to obtain 245 mg of a pure white solid with a yield of 66%.

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Abstract

The invention relates to a fluorescent probe for high-selectivity recognition of phosphate, a preparation method and application, particularly to a quinoline compound, which can be used as a phosphatefluorescent probe for detecting the presence of phosphate or measuring the content of phosphate. The probe can achieve at least one of the following technical effects: the water solubility is good, and the probe is especially suitable for detection or measurement of phosphate in a water environment; high-sensitivity analysis on phosphate can be realized; phosphate is identified with high selectivity; the synthesis is simple; and the property is stable.

Description

technical field [0001] The invention belongs to the field of fluorescent probes, and in particular relates to a fluorescent probe of quinoline compounds and its application in measuring or detecting phosphate; the invention also provides a method for preparing the fluorescent probe. Background technique [0002] Phosphorus is an element ubiquitous in nature, and it is an element necessary to form organism tissues and participate in cell metabolism activities. It plays an extremely important role in human production and life, but at the same time, phosphorus is also the main cause of eutrophication in water bodies. one of the elements. [0003] In the process of rapid economic and social development, many phosphorus-rich substances are inevitably used, but due to irregular use and other reasons, many industrial and agricultural wastewater and domestic sewage are continuously discharged into natural water bodies such as rivers, lakes and oceans. middle. Phosphate levels in s...

Claims

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Application Information

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IPC IPC(8): C07D215/38C09K11/06G01N21/64
CPCC07D215/38C09K11/06G01N21/643C09K2211/1029G01N2021/6417
Inventor 徐晶徐征和朱宝存时延锋徐立荣杨金梁孔珂丛鑫
Owner UNIV OF JINAN