Synthetic method of aromatic aziridine cross-linking agent

Abstract

The invention discloses a synthetic method of an aromatic aziridine cross-linking agent (figure 1). The method comprises three chemical synthesis steps: (I) reacting 1-amino-2-propanol with chlorosulfonic acid to obtain amino-isopropyl sulfate; (II) carrying out an intra-molecular nucleophilic substitution reaction on amino-isopropyl sulfate in alkali liquor, removing sulfate radical groups, and carrying out ring closing to generate an intermediate 2-methyl aziridine; and (III) directly reacting the obtained 2-methyl aziridine with isophthaloyl dichloride in a mixed system of alkali liquor andan organic solvent without separation, and carrying out separation and purification to obtain a final product 1,1'-(1,3-phthaloyl)bis(2-methyl-aziridine). The commodity name is HX-752, and the aromatic aziridine cross-linking agent has wide application. A liquid-liquid homogeneous or heterogeneous reaction is adopted, the reaction conditions are mild, the process is simple and easy to control, and the yield is high. Besides, the synthesis method has the advantages of fewer byproducts and low waste discharge amount, is suitable for large-scale production, and has favorable industrialization prospects.

Description

technical field [0001] The invention relates to the field of synthesis of multifunctional aziridine compounds, in particular to a synthesis method of an aromatic aziridine crosslinking agent. Background technique [0002] Aziridine is the simplest saturated three-membered azacyclic ring with high ring tension and a strong tendency to break the C-N bond in the structure, so that the aziridine ring has high reactivity and is easy to be attacked by protons to open the ring , can react with groups containing active hydrogen such as carboxyl, hydroxyl and amino groups. Aziridine cross-linking agent is a kind of compound containing binary or multi-component aziridine group in molecular structure. Generally, it can react with carboxyl group at room temperature. Under acidic conditions (pH<6), it can also It can react with hydroxyl or amino groups, and its reactivity gradually increases with the increase of temperature. It has the characteristics of fast reaction rate, less dosa...

AI Technical Summary

Problems solved by technology

[0010] The technical problem that the present invention mainly solves is to provide a kind of synthetic method of aromatic aziridine cross-linking agent, to solve the synthetic process of sulfuric acid ester existing in the existing method is loaded down with trivial details, the synthesis of 2-methyl aziridine, separation and It is discontinuous with the subsequent reaction process, which brings problems such as increased process complexity and risk, increased waste discharge, and reduced product yield.

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