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Method for extracting and purifying cannabidiol in industrial hemp

A cannabidiol, industrial hemp technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of unguaranteed product safety, restricting industrial production, and low extraction purity, etc. The effect of cost and solvent usage, less pollution and high product purity

Pending Publication Date: 2020-11-24
滇麻生物科技(曲靖)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high medicinal value of CBD, the total extraction of CBD with high purity from industrial hemp has become the main subject of current research. In the existing technology, the method of extracting CBD from industrial hemp mostly uses carbon dioxide critical extraction, Chromatography and crystallization process, due to, but due to the extensive separation process, and the complex and similar properties of cannabinoids in industrial hemp, especially tetrahydrocannabinol (THC) and cannabidiol (CBD) are isomerism Construct, not only easy to cause the extraction purity of CBD is not high, the problem of extraction rate, but also most of the tetrahydrocannabinol remains in the purified CBD, the safety of the product cannot be guaranteed, which seriously restricts the industrial production of CBD

Method used

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Examples

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Effect test

Embodiment 1

[0023] The method for extracting and purifying cannabidiol from industrial hemp described in the present embodiment 1 comprises the following steps:

[0024] ① Raw material crushing: crush 10kg of industrial hemp flower leaves into flower leaf powder with a particle size of 10 mesh;

[0025] ②Drying: Baking the flower leaf powder obtained by pulverizing in step ①, the baking temperature of the flower leaf powder is 100°C, and baking until the weight loss is more than 7%;

[0026] ③Leaching: adding an extractant to the leaf powder baked in step ②, the extractant is ethanol with a mass concentration of 80-100%, and the solid-to-liquid ratio of the extractant to the leaf powder is 1:6, and then keep the liquid level of the extracting agent at a certain height at 20°C, the liquid level of the extracting agent is 2cm, soak for 8 hours, and then add the extracting agent again according to a certain flow rate, so that the outflow speed of the extracting solution is the same as The a...

Embodiment 2

[0034] The method for extracting and purifying cannabidiol from industrial hemp described in this embodiment 2 comprises the following steps:

[0035] ① Raw material crushing: crush 10kg of industrial hemp flower leaves into flower leaf powder with a particle size of 40 mesh;

[0036] ②Drying: Baking the flower leaf powder obtained by pulverizing in step ①, the baking temperature of the flower leaf powder is 125°C, and baking until the weight loss is more than 7%;

[0037] 3. Lixiviation: adding an extractant to the powder of flowers and leaves baked in step 2. The extraction agent is a mixture of n-hexane and petroleum ether, and the solid-to-liquid ratio of the extraction agent to the powder of flowers and leaves is 1 : 8, then at a temperature of 25°C, the liquid level of the extractant is maintained at a certain height, the liquid level of the extractant is 4cm, and after immersion for 18h, the extractant is added again according to a certain flow rate, so that the outflow...

Embodiment 3

[0045] The method for extracting and purifying cannabidiol from industrial hemp described in this embodiment 3 comprises the following steps:

[0046] ① Raw material crushing: crush 10kg of industrial hemp flower leaves into flower leaf powder with a particle size of 60 mesh;

[0047] ②Drying: Baking the flower leaf powder obtained by pulverizing in step ①, the baking temperature of the flower leaf powder is 150°C, and baking until the weight loss is more than 7%;

[0048] 3. Extraction: adding an extractant to the powder of flowers and leaves baked in step 2. The extractant is a mixture of ethanol, n-hexane, sherwood oil and ethyl acetate with a mass concentration of 100%. The solid-to-liquid ratio of the extraction agent to the flower leaf powder is 1:10, and then the liquid level of the extraction agent is maintained at a certain height at a temperature of 28°C. Extraction agent, so that the extraction liquid outflow speed is the same as the extraction agent addition speed...

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Abstract

The invention discloses a method for extracting and purifying cannabidiol in industrial hemp. The method comprises the following steps: (1) crushing of raw materials; (2) drying; (3) leaching: addinga leaching agent into dried floral leaf powder, and carrying out leaching to obtain a crude extract with a content of 10-15%; (4) dewaxing: dissolving the crude extract with ethanol having a mass concentration of 85-100%, and carrying out freezing and filtering to obtain a CBD enriched product with a content of 25-40%; (5) molecular distillation: carrying out molecular distillation on the CBD-enriched product, wherein the content of collected CBD oil is 35-70%; (6) column chromatography separation: carrying out silica gel column chromatography separation on the CBD oil, reducing a pressure, and conducting concentrating to obtain coarse CBD crystals with a content of 95% or above; (7) recovery of eluate; and (8) recrystallization of CBD: dissolving the coarse CBD crystals with a crystallization solvent, and conducting filtering and the like to obtain a finished CBD product with a content of 99.5% or above. The method is advanced, stable and feasible in process, and has the advantages oflow investment, high benefit, high purity, high extraction rate and low pollution.

Description

technical field [0001] The invention belongs to the technical field of extraction and separation of natural phytochemical components, and in particular relates to a method for extracting and purifying cannabidiol from industrial hemp. Background technique [0002] Industrial hemp refers to cannabis that has been legally grown and contains less than 0.3% tetrahydrocannabinol (THC). At present, industrial hemp has been cultivated on a large scale in Yunnan Province and Heilongjiang Province, and the scale of cultivation has been expanding year by year. Industrial hemp (HEMP) has extremely high medicinal value and is widely used in textiles, paper, food, medicine, hygiene, daily chemicals, leather, automobiles, construction, decoration, packaging and other fields. It is a classic means of production, and also one of the traditional medicinal materials and health care products in my country. At present, people have isolated more than 500 secondary metabolites from cannabis pla...

Claims

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Application Information

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IPC IPC(8): C07C39/23C07C37/68C07C37/82C07C37/74C07C37/84
CPCC07C37/685C07C37/82C07C37/74C07C37/84C07C2601/16C07C39/23
Inventor 尹升权唐瑛高建慎杨成周张岚燕
Owner 滇麻生物科技(曲靖)有限公司
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