1, 3-deuterated dansyl chloride and preparation method and application thereof

A technology of dansyl chloride and deuterium, applied in the field of isotope derivatization reagents, can solve problems such as differences in retention time and large difference in mass number of dansyl chloride
CN112010782AActive Publication Date: 2020-12-01INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Publication Date
2020-12-01

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Abstract

The invention belongs to the technical field of isotope derivatization reagents, and particularly relates to 3-deuterated dansyl chloride and a preparation method and application thereof. According tothe preparation method, 3-deuterated dansyl chloride can be prepared from reaction raw materials including 5-amino-1-naphthalene sulfonic acid, paraformaldehyde, sodium borohydride, sodium hydride, deuterated methyl iodide, phosphorus oxychloride and phosphorus pentachloride. According to the preparation method, the raw materials are easy to obtain, few intermediate products are produced, and the3-deuterated dansyl chloride derivative reagent can be obtained and can be used for fluorescence detection or metabonomics analysis and research.
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Description

technical field

[0001] The invention belongs to the technical field of isotope derivatization reagents, in particular to 3-deuterated dansyl chloride and its preparation method and application. Background technique

[0002] In metabolomics research, small molecular compounds contained in biological samples can reflect the metabolic state of the body, and dansyl chloride can specifically bind to the active hydrogen atoms of small molecular compounds to enhance the mass spectrometric response of small molecular compounds. The combination of isotope dansyl chloride derivatization reagent and dansyl chloride derivatization reagent has outstanding advantages in qualitative identification of metabolites and screening of unknown metabolites; and deuterated dansyl chloride derivatization reagent combined with standard substances can be more It is convenient to obtain the isotope standard of the derivatized standard substance, which is used to supplement the co-elution and matrix eff...

Claims

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