A pharmaceutical composition containing digestive enzymes and its preparation method

A technology of composition and digestive enzymes, which is applied in the field of medicine, can solve the problems of complex multi-layer coating preparation technology, poor preparation stability, and reduced enzyme activity, so as to achieve the effect of expelling intestinal gas, controlling the dissolution rate, and promoting the secretion of pancreatic juice

Active Publication Date: 2022-03-18
广东鼎信医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the compound digestive enzyme preparation of the invention contains enteric-coated digestive enzymes and stomach-soluble digestive enzymes, the enzyme release rate is relatively high and the therapeutic effect is good during use, but the preparation technology of multi-layer coating is complicated and difficult to realize, and the The stability of the preparation is poor, and the activity of the enzyme will decrease after a period of time

Method used

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  • A pharmaceutical composition containing digestive enzymes and its preparation method
  • A pharmaceutical composition containing digestive enzymes and its preparation method
  • A pharmaceutical composition containing digestive enzymes and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 A pharmaceutical composition containing digestive enzymes, including composition A, composition B and composition C;

[0050] The composition A is composed of the following components: 20g of pepsin, 90g of microcrystalline cellulose, 40g of starch, 1g of methylcellulose, 10g of compound dispersant, 1g of magnesium stearate, and 2g of silicon dioxide;

[0051] Said composition B consists of components of the following mass:

[0052] Papain 40g, amylase 10g, ursodeoxycholic acid 20g, microcrystalline cellulose 60g, dextrin 10g, methylcellulose 1g, compound disintegrant 2g, magnesium stearate 1g, silicon dioxide 2g;

[0053] Said composition C consists of components of the following mass:

[0054] Cellulase 10g, trypsin 40g, microcrystalline cellulose 100g, methylcellulose 1g, carmellose calcium 5g, magnesium stearate 1g, silicon dioxide 1g;

[0055] Enteric coating powder 4g, purified water 80g.

[0056] The composite dispersant in the composition A is co...

Embodiment 2

[0071] Embodiment 2 A kind of pharmaceutical composition containing digestive enzyme

[0072] The pharmaceutical composition containing digestive enzymes includes composition A, composition B and composition C;

[0073] In the pharmaceutical composition containing digestive enzymes described therein, the composition A is composed of the following components: 25g of pepsin, 105g of microcrystalline cellulose, 60g of starch, 8g of methylcellulose, 12g of compound dispersant, hard Magnesium fatty acid 2g, silicon dioxide 4g;

[0074] Said composition B consists of components of the following mass:

[0075] Papain 50g, amylase 15g, ursodeoxycholic acid 25g, microcrystalline cellulose 80g, dextrin 14g, methylcellulose 7g, compound disintegrant 5g, magnesium stearate 2g, silicon dioxide 4g;

[0076] Said composition C consists of components of the following mass:

[0077] Cellulase 15g, trypsin 50g, microcrystalline cellulose 112g, methylcellulose 7g, compound disintegrant 10g, m...

Embodiment 3

[0094] Embodiment 3 A kind of pharmaceutical composition containing digestive enzyme

[0095] The pharmaceutical composition containing digestive enzymes includes composition A, composition B and composition C;

[0096]Wherein the composition A is composed of the following components: pepsin 30g, microcrystalline cellulose 120g, starch 80g, methylcellulose 15g, composite dispersant 15g, lubricant 5g, silicon dioxide 8g;

[0097] Said composition B consists of components of the following mass:

[0098] Papain 60g, amylase 20g, ursodeoxycholic acid 30g, microcrystalline cellulose 90g, dextrin 18g, methylcellulose 15g, compound disintegrant 8g, lubricant 5g, silicon dioxide 8g;

[0099] Said composition C consists of components of the following mass:

[0100] Cellulose 20g, trypsin 60g, microcrystalline cellulose 130g, methylcellulose 15g, compound disintegrant 15g, lubricant 3g, silicon dioxide 6g;

[0101] Enteric coating powder 8g, purified water 90g.

[0102] The composit...

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing digestive enzymes and a preparation method thereof. The composition containing digestive enzymes provided by the present invention is composed of compositions A, B, and C, containing ursodeoxycholic acid and 7 kinds of enzymes, which are pepsin 20-30g, papain 40-60g, amylase 10-20g , 10-20g of cellulose, 40-60g of pancreatic enzymes, which can help digestion of carbohydrates, fats, proteins, and cellulose, and promote intestinal gas excretion and bile secretion. And promote the secretion of pancreatic juice, so as to promote food digestion, expel intestinal gas, and eliminate abdominal fullness.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing digestive enzymes and a preparation method thereof. Background technique [0002] Dyspepsia is a clinical syndrome, a disease caused by gastric motility disorder, including gastroparesis and esophageal reflux disease with poor gastric motility. Dyspepsia is mainly divided into functional dyspepsia and organic dyspepsia. Functional dyspepsia belongs to the categories of "gastralgia", "stomach pain" and "noisy" in traditional Chinese medicine. The disease is in the stomach and involves the liver and spleen and other organs. Daozhi and other methods of treatment. There are many causes of indigestion, including chronic inflammation of the stomach and duodenum, which makes the normal peristaltic function of the esophagus, stomach, and duodenum dysfunctional. [0003] For patients with dyspepsia, medical treatment usually and main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/54A61K38/48A61K31/575A61K38/47A61K9/52A61K47/38A61K47/24A61K47/14A61K47/26A61K47/18A61P1/14
CPCA61K38/4873C12Y304/22002A61K38/488C12Y304/23A61K38/47C12Y302/01004C12Y302/01C12Y304/21004A61K38/4826A61K38/54A61K31/575A61K9/4808A61K9/4833A61K9/2054A61K9/2013A61K9/2806A61P1/14A61K2300/00
Inventor 忻蓉张明钱锦花
Owner 广东鼎信医药科技有限公司
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