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Production process of 6-hydroxyhexanoic acid

A technology of hydroxycaproic acid and production process, applied in the field of chemical industry, can solve the problems of complex process and low yield, and achieve the effects of simple process conditions, high yield and easy acquisition.

Inactive Publication Date: 2020-12-11
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is complicated and the yield is low

Method used

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  • Production process of 6-hydroxyhexanoic acid
  • Production process of 6-hydroxyhexanoic acid
  • Production process of 6-hydroxyhexanoic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 10g of poly-6-hydroxycaproic acid, 80g of water, 2ml of 0.1mol / L H 2 SO 4 Put the solution and 10g of methanol into a 250ml distillation flask at one time, put the flask into an oil bath, stir and heat to 100°C with a DF-101S collector type constant temperature heating magnetic stirrer, and react at a constant temperature under a pressure of 0.1MPa for 2h , followed by distillation and dehydration at a temperature of 100°C and a condition of -0.08MPa. The yield of 6-hydroxycaproic acid was 96.8%.

Embodiment 2

[0027] Put 10g of poly-6-hydroxycaproic acid, 80g of water, 2ml of 0.1mol / L HCl solution, and 10g of ethanol into a 250ml distillation flask at one time, put the flask into an oil bath, and use the DF-101S thermal collector Constant temperature heating, stirring and heating with a magnetic stirrer to 100°C, constant temperature reaction under a pressure of 0.1MPa for 2.5h, followed by distillation and dehydration at a temperature of 100°C and a condition of -0.08MPa. The yield of 6-hydroxycaproic acid was 96.4%.

Embodiment 3

[0029] Put 10g of poly-6-hydroxycaproic acid, 100g of water, 2ml of 0.1mol / L formic acid solution, and 15g of methanol into a 250ml distillation flask at one time, put the flask into an oil bath, and use the DF-101S thermal collector Stir and heat with a magnetic stirrer at a constant temperature and heat to 100°C, react at a constant temperature under a pressure of 0.1MPa for 2.5h, and then distill and dehydrate at a temperature of 110°C and a condition of -0.08MPa. The yield of 6-hydroxycaproic acid was 96.0%.

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Abstract

The invention provides a production process of 6-hydroxyhexanoic acid. The production process comprises the step of hydrolyzing poly-6-hydroxyhexanoic acid under an acidic condition. Acidic hydrolysisadopted in the invention has the following beneficial effects: (1) the acid consumption is low; and (2) no by-product is generated.

Description

technical field [0001] The invention belongs to the chemical industry and relates to the field of synthesis of 6-hydroxycaproic acid, in particular to a production process of 6-hydroxycaproic acid. Background technique [0002] 6-Hydroxycaproic acid is a carboxylic acid derivative that undergoes a cyclization reaction to generate caprolactone. Caprolactone is mainly used to produce thermoplastic polycaprolactone, which has good biocompatibility, good permeability and compatibility to drugs, and has relatively satisfactory drug release behavior. [0003] Chinese patent document CN 102924263 A relates to a method for preparing 6-hydroxycaproic acid by catalytic oxidation using cyclohexene as raw material, air as oxidant, and saturated fatty acid as reaction solvent. The conversion rate of cyclohexene in this method is low, and the selectivity of 6-hydroxyhexanoic acid is only 5-15%. [0004] In the Chinese patent document CN 103936580 A, the washing wastewater containing hex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/09C07C59/01
CPCC07C51/09C07C59/01
Inventor 谢传欣
Owner QINGDAO UNIV OF SCI & TECH