Preparation process of N-carbamylglutamic acid

A carbamoylglutamic acid and a preparation process technology are applied in the preparation of organic compounds, the preparation of urea derivatives, chemical instruments and methods, etc., and can solve the problems of high cost, metabolic interference, low output efficiency, etc. Efficiency improvement and cost reduction effect

Inactive Publication Date: 2020-12-11
TIANJIN QUANHECHENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The trade name of N-carbamoylglutamic acid is arginine vitamin. In recent years, a major discovery in the field of pig nutrition is that arginine amino acids play an important role in regulating the body's nutritional metabolism and immune response. Its mechanism and The effect is very clear, and scholars at home and abroad have conducted many reviews on this. However, due to the relatively high cost of arginine, it may interfere with the metabolism of other amino acids when added to the diet at an effective dose. NCG is an endogenous activator of arginine to achieve the purpose of increasing the content of arginine in the body, improving animal production and health
[0006] At present, glutamic acid and potassium cyanate are generally used as raw materials, ureapropionic acid as a catalyst, and the target compound N-carbamoylglutamic acid is obtained through nucleophilic addition reaction and recrystallization purification. The output efficiency of this processing method is Low, unable to meet the needs of large-scale factory production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) The staff uses an electronic balance to weigh according to the ratio of 8 parts of glutamic acid, 2 parts of urea, 5 parts of potassium hydroxide and 2 parts of catalyst, and then add glutamic acid, urea, potassium hydroxide and catalyst in proportion To the reaction box of the heating device, add a corresponding proportion of water treated by the ultrapure water system, and use a high-power electric stirrer to fully mix the internal raw materials, then turn on the heating device to dissolve the solid, and control the temperature at 60-65 degrees ;

[0027] (2) After reacting for 2 hours, let the solution in the reaction box of the heating device stand at room temperature for 16 to 20 hours, acidify it with concentrated hydrochloric acid, and test it with a pH meter to make pH = 6. After standing for 2 to 3 hours, pass The centrifuge carries out centrifugal filtration, and washes to neutrality, obtains crude product;

[0028] (3) recrystallize the crude product in ...

Embodiment 2

[0030] (1) The staff uses an electronic balance to weigh according to the ratio of 8 parts of glutamic acid, 2 parts of urea, 5 parts of potassium hydroxide and 2 parts of catalyst, and then add glutamic acid, urea, potassium hydroxide and catalyst in proportion To the reaction box of the heating device, add the corresponding proportion of water treated by the ultrapure water system, and use a high-power electric stirrer to fully mix the internal raw materials, and then turn on the heating device with an electric heating jacket to dissolve the solids. The temperature is 60-65 degrees;

[0031] (2) After reacting for 2 hours, let the solution in the reaction box of the heating device stand at room temperature for 16 to 20 hours, acidify it with concentrated hydrochloric acid, and test it with a pH meter to make pH = 6. After standing for 2 to 3 hours, pass The centrifuge carries out centrifugal filtration, and washes to neutrality, obtains crude product;

[0032] (3) the crude...

Embodiment 3

[0036] (1) The staff uses an electronic balance to weigh according to the ratio of 8 parts of glutamic acid, 2 parts of urea, 5 parts of potassium hydroxide and 2 parts of catalyst, and then add glutamic acid, urea, potassium hydroxide and catalyst in proportion To the reaction box of the heating device, add a corresponding proportion of water treated by the ultrapure water system, and use a high-power electric stirrer to fully mix the internal raw materials, then turn on the heating device to dissolve the solid, and control the temperature at 60-65 degrees ;

[0037] (2) After reacting for 2 hours, put the solution in the reaction box of the heating device in an ultra-low temperature refrigerator for a period of time, then acidify it with concentrated hydrochloric acid, and test it with a pH meter to make pH = 6, and then let it stand for 1 to 2 hours. , carry out centrifugal filtration by centrifuge, and wash to neutrality, obtain crude product;

[0038] (3) the crude produ...

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PUM

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Abstract

The invention discloses a preparation process of N-carbamylglutamic acid. The invention relates to the technical field of biochemical materials. The preparation process comprises glutamic acid, urea,a catalyst, concentrated hydrochloric acid, distilled water and a plurality of reaction tools. Meanwhile, the preparation efficiency of the N-carbamylglutamic acid is gradually improved by arranging areaction box with a heating device, an electric heating sleeve, a vacuum drying box, a circulating water vacuum pump, an ultralow-temperature refrigerator, a pulverizer, an electronic balance, a PH meter, a centrifugal machine, a high-power electric stirrer, an ultrapure water system and the like, so that the preparation efficiency of the N-carbamylglutamic acid is greatly improved; and in addition, the preparation process can be further suitable for factory-like large-scale processing, and the cost for preparing the N-carbamylglutamic acid is reduced.

Description

technical field [0001] The invention relates to the technical field of biochemical materials, in particular to a preparation process of N-carbamylglutamic acid. Background technique [0002] The Chinese name of NCG is: N-carbamyl glutamic acid. Its molecular formula is C6H10N2O5, its molecular weight is 190.15, and its pure product is a colorless transparent crystal. NCG is insoluble in water and slightly soluble in organic solvents. The isoelectric point of the active substance is 3.02, and its salts are soluble in water. By promoting the endogenous synthesis of arginine, the litter size and newborn weight of animals can be increased, the fertility of male animals can be enhanced, and the growth and development of young animals can be promoted. [0003] NCG is an analogue of N-acetylglutamic acid (NAG). It can function like NAG in animals and participate in the urea cycle of the body. It has a long half-life, stable metabolism, and has a wide range of biological functions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C273/18C07C275/16
CPCC07C273/1809C07C273/189
Inventor 杨廷全李伟德宋艳民
Owner TIANJIN QUANHECHENG TECH
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