Method for synthesizing vitamin D3 in segmented and fixed spectrum band manner

Abstract

The invention relates to the field of photoreaction, in particular to a method for synthesizing vitamin D3 in a segmented and fixed spectrum band mode. Through segmented illumination, 7-dehydrocholesterol is converted into pre-vitamin D3, and then the pre-vitamin D3 is directly converted into vitamin D3, so that the generation of trans-vitamin D3 is reduced. Meanwhile, an ultraviolet lamp of the photoreactor is fixed at a certain wavelength, and the condition of photoreaction is controlled, so that the conversion rate of converting the 7-dehydrocholesterol into the previtamin D3 is increased to 98 percent, and the generation of impurities such as tachysterol and leucterol is reduced. The method mainly comprises the steps of dissolution, illumination and distillation, the synthesis steps ofVD3 are easier to operate, the quality is easier to control, and industrial production is easier.

Description

technical field [0001] The invention relates to the field of photoreactions, in particular to a method for synthesizing vitamin D3 with segmental fixed bands. Background technique [0002] Vitamin D3 (also known as cholecalciferol) is a drug with antirickets activity, which is widely considered to be an important substance regulating calcium and phosphorus metabolism. Before vitamin D3 was discovered, rickets (also known as rickets) was one of the important diseases that plagued human health. The substance can be transformed into an effective anti-chondrosis active substance after being illuminated. In the early 1930s, scientists Waddel and Windous confirmed that the anti-chondrosis active ingredient in the human body is cholecalciferol produced by 7-DHC light, named vitamin D3. [0003] At present, the synthesis of vitamin D3 is mostly composed of 7-dehydrocholesterol by light, removal of tachysterol, removal of 7-dehydrocholesterol, and thermal isomerization steps. The ...

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Problems solved by technology

[0003] At present, the synthesis of vitamin D3 is mostly composed of 7-dehydrocholesterol by light, removal of tachysterol, removal of 7-dehydrocholesterol, and thermal isomerization steps. The ring rate is low, only about 30%, and the remaining 70% of 7-dehydrocholesterol must be recovered and illuminated again. On the other hand, the content of tachysterol generated during the illumination process is relatively high, about 10%. Toxic substances must be removed. The main reason for impurities is that the light source uses high-pressure mercury lamps. High-pressure mercury lamps will generate a lot of heat and have a wide band.

At the same time, in the process of thermal isomerization, if the control conditions are not good, the conformational reversal of vitamin D3 will easily occur, and trans-vitamin D3 will be generated. The whole process is complicated, the yield is not high, and the purity and content are low.