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Specific porphyrin self-transport nano carrier material and preparation method thereof

A nano-carrier and specific technology, applied in the field of specific porphyrin self-transport nano-carrier materials and their preparation, can solve the problems of difficult synthesis, high cost, large metabolic toxicity, etc., and achieve good biocompatibility, cheap raw materials, Simple preparation method

Active Publication Date: 2020-12-25
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the design of carrier materials usually has a series of problems such as difficult synthesis and high cost. More importantly, the introduction of complex compounds into carrier materials makes carrier materials have greater potential metabolic toxicity.

Method used

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  • Specific porphyrin self-transport nano carrier material and preparation method thereof
  • Specific porphyrin self-transport nano carrier material and preparation method thereof
  • Specific porphyrin self-transport nano carrier material and preparation method thereof

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Embodiment 1

[0031] A method for preparing a specific porphyrin self-transporting nano-carrier material (TAPP-TPGS), comprising the following steps:

[0032] 1) Add p-nitrobenzaldehyde (50 mmol, 7.561 g), acetic anhydride (86 mmol, 8.2 Ml) and propionic acid (200 mL) into a two-necked flask, heat the reaction system to 80 °C in an oil bath, and then A mixture of pyrrole (50mmol, 3.5 mL) and propionic acid (10 mL) was slowly dropped into it using a constant pressure dropping funnel. After the dropwise addition, the temperature of the reaction system was raised to 135° C. for reflux reaction for 30 min. It was then cooled to room temperature and placed in a refrigerator at 4°C overnight. The precipitate appeared the next day, filtered, the filter cake was washed with distilled water (3×80 mL), and dried under vacuum at 40°C to obtain the crude product. The crude product was dissolved in 80 mL of pyridine and refluxed for 1 h, cooled to room temperature, and then placed in an ice-water bath ...

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Abstract

The invention relates to a preparation method of a specific porphyrin self-transport nano carrier material. The method comprises the following steps of carrying out a mixed reaction on p-nitrobenzaldehyde, acetic anhydride, propionic acid and pyrrole to obtain purple solid tetra(4-nitrophenyl)porphyrin TNPP, and preparing tetra(4-aminophenyl)porphyrin TAPP; stirring TPGS, succinic anhydride, DMAP,triethylamine and 1,4-dioxane at room temperature, and performing dialysis to obtain carboxyl TPGS; and mixing the carboxyl TPGS, DMAP and PyBOP, adding DMF and TAPP, performing stirring at room temperature for 22-26 hours, performing dialysis, and freeze-drying dialysate to obtain the product TAPP-TPGS. The specific molecules TPGS are introduced into the carrier material, so that the carrier hasthe effect of assisting an anti-tumor drug in treating cancers, and the anti-tumor effect is improved through combined treatment of three modes of TPGS, PDT and chemotherapy.

Description

technical field [0001] The invention belongs to the technical field of preparation of drug-loaded materials, and in particular relates to a specific porphyrin self-transport nano carrier material and a preparation method thereof. Background technique [0002] Chemotherapy is currently one of the most important treatments for cancer, but drugs generally have shortcomings such as short half-life, large side effects, and poor drug resistance. The nano drug delivery system (nano drug delivery system, NDDS) can overcome the shortcomings of clinical chemotherapy to a certain extent, and can increase the solubility of chemotherapy drugs, prolong the circulation time of drugs in the blood, and target drug delivery. However, the effect of single chemotherapy on cancer treatment is not as good as expected, and researchers have begun to explore new treatment methods, such as immune, photothermal, gene and photodynamic therapy. According to research, the effect of chemotherapy combined...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/60A61K31/337A61K49/00A61P35/00
CPCA61K31/337A61K41/0071A61K49/0036A61K49/0054A61K47/60A61P35/00A61K2300/00
Inventor 于树玲袁金涛石家华贾淑鑫王少晨
Owner HENAN UNIVERSITY
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