Sustained-release film coating premix and preparation method thereof
A film-coating, sustained-release technology, applied in sugar-coated pills, pill delivery, pharmaceutical formulations, etc., can solve the problems of low barrier ability, softening, affecting drug storage and use, etc., to improve moisture-proof performance, improve color and luster. The effect of uniformity
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Embodiment 1
[0052] Sustained-release film coating premix prepared by the following method:
[0053] S1. Add 1000g of ethyl cellulose, 500g of black fungus polysaccharide with a polysaccharide content of 50%, 35g of sodium caseinate and 3000g of water into the reaction kettle, heat and stir at 80°C for 4h, filter to obtain a solid, and put the solid in an oven at 50°C Drying for 1 h in the middle to obtain modified ethyl cellulose;
[0054] S2. 650g modified ethyl cellulose, 160g talcum powder, 30g dibutyl sebacate, 80g polyethylene glycol 6000 and 50g mass concentration obtained by S1 step are 95% ethanol at 18 ℃ and uniformly mixed into stirring Mixed solution, stirring the mixed solution for 1 hour, and then drying at 45°C for 4 hours to obtain the primary mixture;
[0055] S3. Add 30g of titanium dioxide and 20g of allure red aluminum lake to the initial mixture obtained in the S2 step, continue mixing for 1h at 18°C, then add to the grinder and grind for 4h, and then sieve the ground...
Embodiment 2
[0057] Sustained-release film coating premix prepared by the following method:
[0058] S1. Add 1000g ethyl cellulose, 500g black fungus polysaccharide with a polysaccharide content of 50%, 60g sodium caseinate and 4000g water into the reaction kettle, heat and stir at 90°C for 4h, filter to obtain a solid, and put the solid in an oven at 50°C Drying for 1 h in the middle to obtain modified ethyl cellulose;
[0059] S2. 750g modified ethyl cellulose, 80g magnesium stearate, 70g triethyl citrate, 100g polyethylene glycol 6000 and 80g mass concentration obtained by S1 step are mixed evenly at 24°C with 95% ethanol to form Stir the mixed solution, stir the mixed solution for 2 hours, and then dry at 35° C. for 6 hours to obtain the primary mixture;
[0060] S3. Add 30g titanium dioxide and 20g allure red aluminum lake to the primary mixture obtained in the S2 step, continue to mix at 24°C for 1h, then add to the grinder and grind for 4h, and then sieve the ground mixture with a ...
Embodiment 3
[0062] Sustained-release film coating premix prepared by the following method:
[0063] S1. Add 1000g of ethyl cellulose, 500g of black fungus polysaccharide with a polysaccharide content of 50%, 20g of sodium caseinate and 3000g of water into the reaction kettle, heat and stir at 85°C for 3h, filter to obtain a solid, and put the solid in an oven at 50°C Dry for 1h to obtain modified ethyl cellulose;
[0064] S2. 720g modified ethyl cellulose, 100g talcum powder, 60g dibutyl sebacate, 60g polyethylene glycol 6000 and 100g mass concentration obtained by S1 step are 95% ethanol at 30 ℃ and uniformly mixed into stirring Mixed solution, stirring the mixed solution for 1 hour, and then drying at 40°C for 5 hours to obtain the primary mixture;
[0065] S3. Add 20g of titanium dioxide and 10g of Allura red aluminum lake to the initial mixture obtained in step S2, continue to mix at 30°C for 0.5h, then add it to a grinder and grind for 5h, and then sieve the ground mixture to a sieve....
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