Molybdenum disulfide quantum dot-chiral gold nano particle assembly as well as preparation method and application thereof

A gold nanoparticle and molybdenum disulfide technology, which is applied in the field of molybdenum disulfide quantum dot-chiral gold nanoparticle assembly and its preparation, can solve the problems of unsuitable real-time analysis, expensive and complex sample pretreatment process, etc.

Active Publication Date: 2020-12-29
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of these methods require expensive chiral columns and complex sample pretreatment processes, and are not suitable for real-time analysis

Method used

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  • Molybdenum disulfide quantum dot-chiral gold nano particle assembly as well as preparation method and application thereof
  • Molybdenum disulfide quantum dot-chiral gold nano particle assembly as well as preparation method and application thereof
  • Molybdenum disulfide quantum dot-chiral gold nano particle assembly as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: In the present embodiment, tetrachloroauric acid trihydrate is adopted.

[0039]Add 0.025mmol of tetrachloroauric acid trihydrate (molecular weight 393.83) and 0.025mmol of N-acetyl-L-cysteine ​​to 50mL of ultrapure water and stir, add 1mL of 4mg / mL (about 0.1mmol) hydroboration Sodium solution, the solution gradually changed from yellow to deep red, and continued to stir at room temperature for 2 hours to obtain a solution of chiral gold nanoparticles functionalized with N-acetyl-L-cysteine. Since the absorbance of gold nanoparticles at 520 nm is 1.861, the concentration of the chiral gold nanoparticles solution is calculated to be about 6.89 nmol / L according to Lambert-Beer's law. figure 1 Infrared spectra of chiral gold nanoparticles functionalized for N-acetyl-L-cysteine ​​and N-acetyl-L-cysteine, from the infrared spectrum of N-acetyl-L-cysteine ​​can be It can be seen that at 2547cm -1 There is an obvious peak at , which is due to the stretching vi...

Embodiment 2

[0041] The preparation of molybdenum disulfide quantum dots includes the following steps: dissolve 0.5mmol sodium molybdate dihydrate in 10mL ultrapure water, stir ultrasonically for 5min, add HCl to adjust the pH to 6.5, add 2mmol reduced glutathione and 20mL ultrapure water Pure water, after ultrasonication for 10min, transfer the solution into a polytetrafluoroethylene reactor, react at a constant temperature of 200°C for 24h, cool to room temperature and centrifuge for 5min, collect the supernatant to obtain a yellow molybdenum disulfide quantum dot dispersion. figure 2 It is a transmission electron microscope picture of molybdenum disulfide quantum dots. It can be seen from the figure that the molybdenum disulfide quantum dots are well dispersed, the size distribution is uniform, and the average particle size is about 3nm.

Embodiment 3

[0042] Example 3: Preparation of molybdenum disulfide quantum dots-chiral gold nanoparticle assembly: Pipette 1mL of N-acetyl-L-cysteine ​​functionalized chiral gold nanoparticle solution prepared in Example 1 , adding 25 μL of the molybdenum disulfide quantum dot dispersion solution prepared in Example 2, mixing and incubating for 10-20 min, and the molybdenum disulfide quantum dot-chiral gold nanoparticle assembly can be obtained.

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Abstract

The invention discloses a molybdenum disulfide quantum dot-chiral gold nano particle assembly and a preparation method and application thereof. Molybdenum disulfide quantum dots prepared by a hydrothermal method are taken as a fluorescent luminous body, N-acetyl-L-cysteine functionalized chiral gold nano particles and molybdenum disulfide quantum dots are combined and assembled into a molybdenum disulfide quantum dot chiral gold nano particle assembly. After the chiral gold nano particles are combined with the molybdenum disulfide quantum dots, the photo-induced electron transfer effect is generated, so that the fluorescence of the molybdenum disulfide quantum dots can be effectively quenched, after protein amino acidenantiomer with chirality is added, the protein amino acid enantiomer canbe combined with N-acetyl-L-cysteine on the surfaces of the chiral gold nano particles through hydrogen bonds, so that the chiral gold nano particles are induced to be agglomerated to different degrees, electron transfer is blocked, fluorescence of the molybdenum disulfide quantum dots is recovered, and chiral recognition of the protein amino acid enantiomer is realized.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and molecular recognition, and specifically relates to a molybdenum disulfide quantum dot-chiral gold nanoparticle assembly and its preparation method and application. Background technique [0002] Amino acids play important roles in all living things and are the building blocks of proteins and metabolic intermediates. With the exception of glycine, all proteinogenic amino acids are chiral. The study of amino acid enantiomeric recognition can provide important information, contribute to a better understanding of chiral recognition in biological systems, and further promote the progress of biochemical and pharmaceutical research. Commonly used chiral separation techniques include high performance liquid chromatography, gas chromatography, and capillary electrophoresis. However, most of these methods require expensive chiral columns and complicated sample pretreatment processes, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/68C09K11/58B82Y20/00B82Y30/00B82Y40/00B22F9/24C01G39/06G01N21/64
CPCC09K11/681C09K11/58B82Y20/00B82Y30/00B82Y40/00B22F9/24C01G39/06G01N21/6428C01P2002/82C01P2004/04C01P2006/60C01P2004/64G01N2021/6432Y02B20/00
Inventor 孔泳赵倩倩吴大同
Owner CHANGZHOU UNIV
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