A kind of preparation method of high specific surface area chitosan microsphere

Abstract

The invention relates to a novel method for preparing chitosan microspheres with a high specific surface area, belonging to the technical field of materials. The preparation method is to uniformly mix chitosan solution and agarose solution in advance, and obtain chitosan / agarose composite microspheres through emulsification and regeneration processes, and then remove agarose by heat treatment to obtain chitosan with high specific surface area Microspheres. The results show that the specific surface area of ​​chitosan microspheres prepared by this preparation method is significantly improved. At the same time, the present invention uses agarose as a pore-forming agent, which is low in cost, has no pollution to the environment, is easy to degrade, and does not cause the collapse of the pore structure. scope of application.

Description

technical field [0001] The invention belongs to the technical field of materials and relates to a method for preparing chitosan microspheres with high specific surface area. Background technique [0002] Chitosan is the only alkaline polysaccharide that exists in nature. Its molecular structure is 2-acetylamino-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose connected by glycosidic bonds. polymer. Commercial chitosan is mainly obtained from raw materials rich in chitin, such as shrimp and crab, after deacetylation treatment. Generally, chitin with a degree of deacetylation greater than 50% is called chitosan. Chitosan has unique physical and chemical properties, such as cationic polyelectrolyte, antibacterial, non-toxic and biocompatibility. At the same time, due to its rich hydroxyl and amino groups, chitosan-based materials with different functions can be obtained by reacting with other functional monomers or hybridization, which shows great application pote...

AI Technical Summary

Problems solved by technology

However, the currently existing chitosan microspheres generally have the disadvantage of low specific surface area, which is mainly due to the high crystallinity of chitosan fibers caused by internal strong hydrogen bonds, resulting in a decrease in specific surface area.

This high crystallinity results in a large number of hydroxyl and amino groups buried in the crystalline region, which greatly limits the further functionalization of chitosan.

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