Method for preparing composite sponge for treating dry socket

Abstract

The invention discloses a method for preparing a composite sponge for treating the dry socket. The method comprises the steps of: mixing staphylococcus aureus bacterial walls with sodium alginate solution, carrying out pre-freezing, and carrying out freeze-drying in a freeze dryer to obtain a staphylococcus aureus bacterial wall sponge; preparing mixed solution from gelatin, chitosan and calcium lactate; and adding the mixed solution into the staphylococcus aureus bacterial wall sponge, and carrying out freeze-drying after pre-freezing. According to the invention, the composite sponge is constructed by utilizing the typing change of immune cells after bacterial infection, adopting the bacterial walls of staphylococcus aureus and taking the chitosan, the gelatin and sodium alginate as matrices; research finds that the composite sponge prepared by the method disclosed by the invention not only can effectively regulate and control typing transformation of the local immune cells such as macrophages and the like to promotion of tissue repair, but also can effectively avoid the inflammatory reaction caused by bacterial infection, so that a good treatment effect is achieved on the dry socket; and the composite sponge has high clinical application value.

Description

technical field

[0001] The invention belongs to the technical field of dry socket treatment, and in particular relates to a method for preparing a composite sponge for treating dry socket. Background technique

[0002] Dry socket is one of the common complications after tooth extraction in oral surgery. It is more common in mandibular posterior teeth, especially after extraction of impacted mandibular third molars. Under normal circumstances, even with flap bone removal and tooth extraction, The wound pain will gradually disappear after 2 to 3 days. If severe pain occurs 2 to 3 days after tooth extraction, and the pain radiates to the ear-temporal region, submandibular area or the top of the head, and cannot be relieved by general analgesic drugs, it may have occurred. Dry socket. Clinical examination shows that the alveolar socket is empty, or there are corrupted blood clots, which are grayish white. The dead matter covering the wall of the alveolar socket has an odor, an...

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