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Medicine for reducing skin wound scars and application thereof

A skin wound and drug technology, applied in the field of biomedicine, can solve the problems of hypertrophic scar healing, high cost, low activity, etc., and achieve the effect of repairing skin wounds and reducing the formation of scars

Active Publication Date: 2021-01-08
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional wound healing drugs have certain limitations, such as high cost, relatively low activity and easy to cause hypertrophic scar healing

Method used

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  • Medicine for reducing skin wound scars and application thereof
  • Medicine for reducing skin wound scars and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: preparation pharmaceutical preparation

[0024] According to the formulation in Table 1 below, the prepared polypeptide was mixed with amoxicillin, and then mixed with PBS solution with a pH of 8.0 to form a mixed solution to obtain a liquid preparation.

[0025] Table 1: Proportions of Liquid Preparations

[0026] serial number Polypeptide (wt%) Amoxicillin (wt%%) Mass ratio of peptide to amoxicillin 1 3％ 0 - 2 2.5％ 0.02％ 125:1 3 2.0％ 0.02％ 100:1 4 1.5％ 0.02％ 75:1 5 1.0％ 0.02％ 50:1 6 0 0.02％

[0027] Add 5% fresh blood dropwise to the prepared liquid drug preparation, and let it stand after mixing evenly, wherein liquid preparations 2-4 in Table 1 can form a stable gel within 3 minutes, while liquid preparations 1, 5 and 6 Difficult to form a stable gel, still in liquid state. The gels obtained from liquid formulations 2-4 were subjected to frequency sweeping rheology experiments at 25°C and...

Embodiment 2

[0028] Embodiment 2: pharmacodynamic experiment

[0029] Experimental tests related to wound repair were carried out on the drug for reducing skin trauma and scar prepared in Example 1.

[0030] Wound repair test: Take 65 healthy mice, all of which are male, depilate the back of the mice, and disinfect them; intraperitoneally inject 10% chloral hydrate to anesthetize the mice, use laboratory scissors to prepare a wound on the back of the mouse, and the wound area is 1cm 2 about. After modeling, the mouse wound area was photographed, which was recorded as day 0. 65 model mice were randomly divided into 5 groups, which were blank control group (group 1, no drug treatment), positive control group (group 2, one group was given the preparation of number 1, and the other group was given the preparation of number 6). preparation) and treatment group (2 groups, one group was given the preparation number 3, and the other group was given the preparation number 4), 13 rats / group. Both...

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PUM

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Abstract

The invention relates to a medicine for reducing skin wound scars and application thereof. The medicine contains polypeptide and amoxicillin, wherein the polypeptide has an amino acid sequence as shown in SEQ ID NO. 1 or an amino acid sequence which is lack of, replaces any one amino acid or increases one amino acid compared with the sequence as shown in SEQ ID NO. 1. The polypeptide Ser-His-Ser-Gly-Phe-Pho contained in the medicine for skin wounds and amoxicillin can form gel at the wound part, and the synergistic effect of the two contributes to repairing the skin wounds, and particularly can reduce the formation of scars.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a medicine for reducing skin trauma scars, a preparation method and application thereof. Background technique [0002] Skin wounds and scalds are clinically common diseases. The epidermis, dermis and subcutaneous tissue are damaged due to external causes (cutting wounds, blunt trauma, accidental injuries, water and fire burns, chronic skin ulcers, etc.) or internal causes (such as bedsores, etc.), often causing The pain is unbearable for patients, and in severe cases, it will cause skin tissue necrosis. Improper treatment will cause severe skin ulceration, and the wound is difficult to heal. The skin is the largest organ in the human body, serving as a physical barrier between the human body and the external environment, and it undertakes many important physiological functions, including perspiration, heat and pain sensation. Once the skin is damaged, it will caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P17/02A61K31/43
CPCA61K38/08A61K31/43A61P17/02A61K2300/00
Inventor 夏卫东林才赵胜戴文统干添元
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV