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Quality control method of ginger and magnolia officinalis formula granules

A quality control method and technology of formula granules, which are applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as staying in the laboratory stage and have not yet involved in applied research, and achieve the effect of strong operability

Active Publication Date: 2021-01-08
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technologies have carried out relatively comprehensive research on Magnolia officinalis medicinal materials, decoction pieces, and formula granules, but all kinds of research are still in the laboratory stage, and have not yet involved applied research that can be popularized and applied in large-scale production

Method used

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  • Quality control method of ginger and magnolia officinalis formula granules
  • Quality control method of ginger and magnolia officinalis formula granules
  • Quality control method of ginger and magnolia officinalis formula granules

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The preparation method of the mixed reference substance solution is as follows: accurately weigh 5.50 mg (purity 94.9%) of syringin reference substance, 2.52 mg (purity 98.27%) of magnololine reference substance, and 4.20 mg (purity 94.9%) of magnolialine reference substance respectively. 99%), magnolol reference substance 7.93mg (purity 98.3%), magnolol reference substance 11.49mg (purity 98.8%), honokiol reference substance 3.03mg (purity 99.3%), add methanol respectively, ultrasonic dissolution, Dilute to 10mL, make their respective reference solution, add methanol to make 1mL containing syringin 0.087mg, magnololine 0.041mg, magnolialine 0.069mg, magnoliadin 0.130mg, magnolia A mixed reference solution of phenol 0.189mg and honokiol 0.050mg.

[0050]The preparation method of described need testing solution is: get about 0.1g of this product powder (through No. 2 sieve), accurately weighed, put in a stoppered Erlenmeyer flask, accurately add 10ml of 50% ethanol, seal...

Embodiment 1

[0064] Example 1 Construction of Jianghoupu standard decoction contrast feature map

[0065] This embodiment includes the following steps:

[0066] 1) Collect 29 batches of Magnolia officinalis medicinal materials from the main authentic places of Magnolia officinalis in Hubei, Sichuan, Chongqing, etc., screen out the unqualified batches, and process the qualified batches of medicinal materials into 19 batches of qualified ginger magnolia decoction pieces (see Table 1). Refer to the instructions The standard decoction preparation, test sample preparation, reference substance solution preparation and sample determination methods in the text obtained 19 batches of ginger magnolia standard decoction HPLC chromatograms.

[0067] Table 1 Origin information of different batches of Ginger Magnolia officinalis

[0068] serial number batch number place of origin 1 HP-01 Xintang Town, Enshi City, Hubei Province 2 HP-02 Shuanghe Town, Enshi City, Hubei Prov...

Embodiment 2

[0079] Example 2 Comparison of Similarity of Characteristic Maps in Each Process of Ginger Magnolia Formula Granules

[0080] Randomly take a batch of Ginger Magnolia officinalis in dynamic production, take its medicinal materials, decoction pieces, extracts, concentrates and standard decoction freeze-dried powder for characteristic map analysis, measure the characteristic map, and calculate the characteristic map of each sample and the standard decoction comparison characteristic map The similarity, the results are shown in Table 4, image 3 . image 3 Middle, S1: herbs, S2: decoction pieces, S3: extract, S4: concentrate, S5: intermediate, S6: finished formula granules, S7: standard decoction freeze-dried powder, R: control map.

[0081] Table 4 Calculation results of similarity in different processes of Jianghoupu formula granules

[0082]

[0083] From the above results, it can be seen that the corresponding positions of the chromatograms of ginger officinalis medicina...

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Abstract

The invention discloses a quality control method of ginger and magnolia officinalis formula granules. The quality control method comprises the following steps: preparing different batches of ginger and magnolia officinalis standard decoction freeze-dried powder; detecting the freeze-dried powder by adopting an HPLC method, and producing a contrast characteristic spectrum through HPLC chromatogramsof multiple batches of ginger and magnolia standard decoction to obtain the relative retention time of 9 chromatographic peaks; detecting any batch of magnolia officinalis from medicinal materials, decoction pieces, an extracting solution, a concentrated solution, an intermediate and a formula granule finished product according to the same liquid phase condition in actual production, comparing anobtained chromatogram is compared with a contrast characteristic pattern for analysis, and determining the quality of magnolia officinalis formula granules to be detected. The method provided by theinvention is integrally controlled, has strong operability, and provides scientific and reasonable basis for formulating technological standards and quality standards of the ginger and magnolia officinalis formula granules.

Description

technical field [0001] The invention relates to the field of quality control of traditional Chinese medicines, in particular to a method for quality control of ginger magnolia formula granules. Background technique [0002] All pharmaceutical studies of traditional Chinese medicine formula granules must be compared with its standard decoction to ensure the quality consistency with the standard decoction. Therefore, the quality standard research of standard decoction is particularly important for judging the process standards and quality standards of later formula granules. [0003] Ginger officinalis, as a commonly used bulk traditional Chinese medicine, has the functions of drying dampness and eliminating phlegm, lowering qi and eliminating fullness. It is clinically used in damp stagnation and injury, abdominal distension, vomiting and diarrhea, food accumulation and stagnation of qi, abdominal distension and constipation, phlegm and retention, asthma and cough, etc. In th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/74G01N30/86
CPCG01N30/02G01N30/74G01N30/8679
Inventor 翟红伟李清安成焕波龙林靳步昆黄海华孙代华黄茜茜胡辉
Owner 劲牌持正堂药业有限公司
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