Probiotic microcapsule as well as preparation method and application thereof

Abstract

The invention discloses a preparation method of a probiotic microcapsule. The preparation method comprises the following steps: obtaining a mixed bacterium suspension; adding prebiotics, a natural polymer and sodium alginate into the mixed bacterium suspension for mixing, and carrying out emulsification and primary curing to form a primary microcapsule; and putting the primary microcapsule into achitosan solution for secondary curing. The skin probiotic microcapsule prepared by the method has good effects of moisturizing, removing acnes and maintaining micro-ecological balance of skin, also has good stability, and can be matched with a solvent for use or applied to the field of cosmetics as a cosmetic component.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a probiotic microcapsule and a preparation method and application thereof. Background technique [0002] The normal microbiota plays an active role in maintaining the physiological functions of the body, and the imbalance of the micro-ecological environment caused by any physical or chemical factors will affect the health of the body. As the organ with the largest surface area in the human body, the skin also hosts a variety of microbial communities. The skin micro-ecological system is a whole composed of various microorganisms, tissue cells on the skin surface, various secretions, and micro-environment. They maintain the skin micro-ecological balance, form the first biological barrier on the skin surface, and have important physiological functions. effect. More and more studies have shown that many skin problems are associated with skin microecology, for example, the s...

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Problems solved by technology

[0006] Chinese patent CN104856924B discloses "a method for preparing probiotic microcapsules for external use", which is characterized in that bifidobacteria, Lactobacillus acidophilus, and Lactobacillus rhamnosus are microencapsulated by using sodium alginate and kudzu rice extract Wet capsules were obtained by chemical embedding. The main disadvantages are: the capsule material is sodium alginate and the extract of Pueraria japonica, the ingredients are relatively simple, and the composition of the extract of Pueraria japonica is not clear; the microencapsulation process adopts single-layer embedding , the microcapsule skeleton is too loose, and the microcapsules are easily broken after oral administration or during storage, causing bacteria to leak to the outside of the microcapsules; the patented product exists in the form of wet capsules, which is not conducive to the later preservation of the microcapsules

[0007] Chinese patent CN106727263A discloses "skin microecological improvement preparation and its preparation method", which is characterized in that probiotic powder, probiotic fermentation liquid and conventional auxiliaries are compressed into tablets to obtain probiotic tablets, which have the functions of moisturizing and softening the skin , its disadvantages are: probiotics are very sensitive to the adverse environment of the outside world, and have not been embedded. When probiotics are imported into the skin surface, they are easily affected by skin secretions, and it is difficult to maintain enough live probiotics to colonize the skin; In addition, the patent only studies the probiotic survival rate of the probiotic tablet at room temperature and storage temperature within 30 days, and the shelf life is too short to explain the stability of the probiotic in the product

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