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Fructose diphosphate sodium reverse osmosis concentrated solution and preparation method thereof

A technology of sodium fructose diphosphate and reverse osmosis concentrate, applied in the field of medicine, can solve the problems of complicated preparation process, need to be studied, affecting the safety of use and the like

Active Publication Date: 2021-01-22
BEIJING HUAJIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if traditional acidic pH regulators (such as hydrochloric acid and sulfuric acid) are added to adjust the pH value, ions will be introduced, resulting in an increase in osmotic pressure and affecting its safety in use. Therefore, desalination treatment needs to be added to remove the introduced ions , at the same time, the concentration of the system will be reduced, and the intensity of reverse osmosis treatment will need to be strengthened later, which will increase the complexity of the preparation process, reduce production efficiency, increase production costs, and will also lead to an increase in wastewater discharge, which will increase the difficulty of subsequent wastewater treatment
[0005] Therefore, the method for preparing sodium fructose diphosphate reverse osmosis concentrate remains to be studied at present

Method used

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  • Fructose diphosphate sodium reverse osmosis concentrated solution and preparation method thereof

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Effect test

Embodiment 1

[0033] Add 2000L of purified water into the configuration tank, add 125kg of sodium fructose diphosphate raw material powder under stirring, then add purified water to 2250L, continue stirring for 30 minutes, and the pH of the solution is 5.7. D001 strong acidic cation exchange resin was used as the pH regulator to adjust the pH value to 3.2-3.5, the elution rate was 15L / h, and 2200L of the effluent was collected. Then, use about 200L of purified water to push the liquid medicine in the liquid distribution tank and the titanium rod filter into the decolorization tank. The decolorized filtrate is passed through a microporous filter to remove a small amount of carbon residue and then poured into the circulation tank. Then, use about 200L of purified water to push the liquid medicine in the decolorization tank and microporous filter into the circulation tank. Start the reverse osmosis machine to concentrate the liquid medicine in the circulation tank by 10 times. Start the spra...

Embodiment 2

[0035] Add 2000L of purified water into the configuration tank, add 125kg of sodium fructose diphosphate raw material powder under stirring, then add purified water to 2250L, continue stirring for 30 minutes, and the pH of the solution is 5.7. D001 strong acidic cation exchange resin was used as the pH regulator to adjust the pH value to 3.2-3.5, the elution rate was 15L / h, and 2200L of the effluent was collected. Add 1.1 kg of activated carbon for injection, stir evenly, and decolorize for 30 minutes under stirring. After filtering and decarburizing through a titanium rod filter, the decolorized filtrate circulates for 3-5 minutes, and then collects the decolorized filtrate into the decolorization tank. Now record the pH value of the decolorized filtrate to be 2.9, then adjust the pH of the decolorized solution with D201 type strongly basic anion exchange resin, the elution flow rate is 25L / h, then record the pH value of the eluent to be 3.3. Then, use about 200L of purified...

Embodiment 3

[0037] Add 2000L of purified water into the configuration tank, add 125kg of sodium fructose diphosphate raw material powder under stirring, then add purified water to 2250L, continue stirring for 30 minutes, and the pH of the solution is 5.5. D001 strong acidic cation exchange resin was used as the pH regulator to adjust the pH value to 3.2-3.5, the elution rate was 16L / h, and 2200L of the effluent was collected. Add 1.5 kg of activated carbon for injection, stir evenly, and decolorize for 30 minutes under stirring. After filtering and decarburizing through a titanium rod filter, the decolorized filtrate circulates for 3-5 minutes, and then collects the decolorized filtrate into the decolorization tank. Now record the pH value of the decolorized filtrate to be 2.8, then adjust the pH of the decolorized solution with D201 type strongly basic anion exchange resin, the elution flow rate is 18L / h, then record the pH value of the eluent to be 3.4. Then, use about 200L of purified...

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Abstract

The invention provides a method for preparing a fructose diphosphate sodium reverse osmosis concentrated solution. The method comprises the following steps of: dissolving fructose diphosphate sodium in water to obtain a fructose diphosphate sodium aqueous solution, wherein the pH value of the fructose diphosphate sodium aqueous solution is 5-6; adding the fructose diphosphate sodium aqueous solution into a strong acid cation exchange resin column, and collecting effluent, wherein the pH value of the effluent is 3.2-3.5, and the strong acid cation exchange resin is selected from strong acid cation exchange resin; and performing reverse osmosis treatment on the effluent to obtain the fructose diphosphate sodium reverse osmosis concentrated solution. According to the method provided by the invention, the pH value is adjusted by adopting the strong acid cation exchange resin, the introduction of ions is reduced, and meanwhile, phosphate radicals and other impurities can be removed, so thatthe fructose diphosphate sodium reverse osmosis concentrated solution is high in stability and high in purity. Moreover, the method is simple, convenient and rapid to operate and suitable for wide popularization and application.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to sodium fructose diphosphate reverse osmosis concentrate and a preparation method thereof. Background technique [0002] Fructose diphosphate sodium, alias 1,6 diphosphate fructose, English name: Fructose Diphosphate Sodium, is a cell metabolite existing in the human body, can regulate the activity of various enzymes in glucose metabolism, and improve the effects of cellular hypoxia and ischemia state, which is conducive to the recovery of damaged liver cells. According to reports, exogenous sodium fructose diphosphate can increase the concentration of adenosine triphosphate and creatine phosphate in cells by activating the activity of phosphofructokinase and pyruvate kinase, and promote the influx of potassium ions, which is beneficial to ischemia and hypoxia. Cell energy metabolism and glucose utilization in the state, so as to reduce the damage of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P3/00
CPCA61K31/7024A61P3/00
Inventor 王硕万龙熊辉雷杰杰
Owner BEIJING HUAJIN PHARM CO LTD
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