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A kind of preparation method of lysinoprofen

A technology of lysine and lysine hydrochloride, which is applied in the preparation of organic compounds, the preparation of carboxylic acid amides, and the preparation of cyanide reactions, can solve the problems such as product yield and purity to be improved, and achieves simple method and easy operation. , good quality effect

Active Publication Date: 2021-11-02
四川维奥制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the yield and purity of its product all need to be improved

Method used

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  • A kind of preparation method of lysinoprofen
  • A kind of preparation method of lysinoprofen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The method for lysine hydrochloride concentration comprises the following steps:

[0054] A. Add lysine hydrochloride to purified water of 1 times its mass, heat to 60°C and keep warm to prepare solution A;

[0055] B. Take the cation exchange resin column and rinse it with purified water, adjust the flow rate to 200ml / min, add solution A evenly from the upper end of the resin column, perform ion exchange, control the flow rate of the effluent from the lower end of the resin column to 200ml / min, and add purified water to wash Remove, collect the effluent for detection; stop elution when the chloride ion content of the effluent is ≤5 μg / ml;

[0056] C. add the ammoniacal liquor that concentration is 5% to analyze in the cation exchange resin column, collect the ammoniacal liquor analytical solution, obtain solution B;

[0057] D. Concentrating solution B under reduced pressure at a temperature of 60°C to obtain a lysine concentrate with a specific gravity of 1.145;

[...

Embodiment 2

[0064] The method for lysine hydrochloride concentration comprises the following steps:

[0065] A. Add lysine hydrochloride to purified water twice the mass, heat to 30°C and keep warm to prepare solution A;

[0066] B. Take the cation exchange resin column and wash it with purified water, adjust the flow rate to 100ml / min, add solution A evenly from the upper end of the resin column, perform ion exchange, control the flow rate of the effluent from the lower end of the resin column to 100ml / min, and add purified water to wash Remove, collect the effluent for detection; stop elution when the chloride ion content of the effluent is ≤5 μg / ml;

[0067] C. add the ammoniacal liquor that concentration is 5% to analyze in the cation exchange resin column, collect the ammoniacal liquor analytical solution, obtain solution B;

[0068] D. Concentrating solution B under reduced pressure at a temperature of 30°C to obtain a lysine concentrate with a specific gravity of 1.100;

[0069] ...

Embodiment 3

[0075] The method for lysine hydrochloride concentration comprises the following steps:

[0076] A. Add lysine hydrochloride to purified water of 5 times its mass, heat to 70°C and keep warm to prepare solution A;

[0077] B. Take the cation exchange resin column and wash it with purified water, adjust the flow rate to 350ml / min, add solution A evenly from the upper end of the resin column, perform ion exchange, control the flow rate of the effluent from the lower end of the resin column to 350ml / min, and add purified water to wash Remove, stop elution when the chloride ion content of the effluent is ≤5μg / ml;

[0078] C. add the ammoniacal liquor that concentration is 5% to analyze in the cation exchange resin column, collect the ammoniacal liquor analytical solution, obtain solution B;

[0079] D. Concentrating solution B under reduced pressure at a temperature of 70°C to obtain a lysine concentrate with a specific gravity of 1.160;

[0080] The prepared lysine concentrate ...

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Abstract

The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation method of lysaminoprofen. The method includes the following steps: reacting lysine hydrochloride with ibuprofen after concentrating; decolorizing with active carbon and crystallizing with ethyl acetate to prepare it. The method for preparing lysinoprofen is relatively simple, does not require special equipment, is easy to operate, and has good process controllability; and the finished product is of good quality and high purity.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation method of lysaminoprofen. Background technique [0002] Ibuprofen (1buprofen) is a non-steroidal antipyretic and analgesic drug with high efficiency and low toxicity. In addition to being used for long-term treatment of rheumatism and rheumatoid arthritis, it is also used for neuralgia, toothache, headache, Acute treatment of cold syndrome, etc. Due to the low water solubility of the drug, there are only tablets and capsules in clinical practice, no injections. Water-soluble salt, which lays the foundation for the preparation of ibuprofen injection. Increase the route of administration, and at the same time it can reduce the irritation of the digestive tract according to the high bioavailability of ibuprofen. [0003] Ibuprofen has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action reduces the synthesis of prosta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C231/02C07C233/51C07C227/40C07C229/26C07C231/24
CPCC07C227/40C07C231/02C07C231/24C07C233/51C07C229/26
Inventor 吴庆陈国文杨华承于润丽代瑛唐小沁苏兰生红蕾叶小苛何廷廖丹余天容唐勇李玉玲刘航饶茂秋张显坤李长玲张曼曼王艳廖光丹尹华国谢宇
Owner 四川维奥制药有限公司