Salt of gabapentin and 2, 6-pyridine dicarboxylic acid as well as preparation method and application thereof
A technology of dipicolinic acid and gabapentin is applied in the fields of medical application and crystallization technology, which can solve problems such as chemical instability, and achieve the effects of high purity, simple and feasible preparation method and good reproducibility.
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Embodiment 1
[0059] Under room temperature conditions, gabapentin (34.2g) and 2,6-pyridinedicarboxylic acid (33.4g) bulk drug are completely dissolved in 500ml ethanol solution, the solution is filtered and slowly volatilized to remove the solvent at room temperature to obtain gabapentin and 2 , the salt of 6-pyridinedicarboxylic acid (65.8 g).
[0060] The prepared salt was subjected to solid-state characterization, Figure 1-Figure 4 Respectively show embodiment 1 gabapentin and 2, the X-ray single crystal diffraction pattern (SCXRD), X-ray powder diffraction pattern (XRPD), differential scanning calorimetry (DSC), thermal TGA.
Embodiment 2
[0062] Under room temperature conditions, gabapentin (34.2g) and 2,6-pyridinedicarboxylic acid (33.4g) were added into ethanol solvent according to the molar ratio of 1:1, until it was stirred into a suspended state at room temperature, reaction 3 day, filtered, and dried at room temperature to obtain a salt of gabapentin and 2,6-pyridinedicarboxylic acid (68.0 g).
Embodiment 3
[0064] At room temperature, gabapentin (34.2g) and 2,6-pyridinedicarboxylic acid (33.4g) were added into methanol solvent at a molar ratio of 1:1 until they were stirred into a suspension at room temperature. Reaction 3 day, filtered, and dried at room temperature to obtain a salt of gabapentin and 2,6-pyridinedicarboxylic acid (65.8 g).
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