Lactobacillus rhamnosus capable of intervening in metabolic syndrome and application

A technology of Lactobacillus rhamnosus and metabolic syndrome, applied in the field of microbiology, can solve the problem of the lack of research on probiotics in the colon intestinal barrier, and achieve the restoration of intestinal flora imbalance, maintenance of intestinal barrier, and improvement of excessive weight gain. Effect
CN112322528AActive Publication Date: 2021-02-05JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2021-02-05

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Abstract

The invention discloses lactobacillus rhamnosus capable of intervening in metabolic syndrome and an application, in particular to a strain capable of intervening in metabolic syndrome. The lactobacillus rhamnosus can be added into various healthy foods and health-care foods, and belongs to the technical field of microorganisms. The invention provides lactobacillus rhamnosus CCFM1146 as well as a composition, a fermented food, an application, a microbial agent and a microbial agent preparation method thereof. According to the lactobacillus rhamnosus CCFM1146, the metabolic syndrome caused by high-fat diet are remarkably improved; the blood glucose, glucose tolerance and insulin resistance index level of metabolic syndrome mice are remarkably improved; the abundance of microorganisms in intestinal tracts is remarkably improved, and a colon barrier structure is maintained; and the level of proinflammatory factor IL-6 in liver is remarkably improved. The lactobacillus rhamnosus CCFM1146 isused for preparing pharmaceutical compositions and the fermented food for relieving the metabolic syndrome, non-alcoholic fatty liver disease, diabetes and other diseases, and has a very wide application prospect.
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Description

technical field

[0001] The invention relates to a strain of Lactobacillus rhamnosus capable of interfering with metabolic syndrome and its application, especially a strain capable of interfering with metabolic syndrome, which can be added to various health foods and health foods, and belongs to the technical field of microorganisms. Background technique

[0002] Metabolic syndrome (MS) is a group of central obesity, hyperglycemia (diabetes or impaired glucose regulation), dyslipidemia (including high TG and / or low HDL-C blood), and hypertension. At the same time, there are multiple risk factors based on abnormal glucose metabolism and lipid metabolism that gather together to promote the occurrence and development of various cardiovascular and cerebrovascular diseases such as type II diabetes and atherosclerosis. In recent years, with the continuous development of my country's economic and social level, the living standards of the public have continued to improve, the proport...

Claims

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