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Aspirin ticlopidine compound preparation and preparation method thereof

A technology of ticlopidine and aspirin, which is applied in the field of medicine, can solve the problems of side effects, increase the cost of buying medicines for patients, cannot accurately control the ratio of the two medicines, etc., achieves small side effects, no obvious adverse reactions, and reduces the number of administrations Effect

Active Publication Date: 2021-12-28
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients need to take two kinds of medicines separately, which not only increases the cost of buying medicines for patients, but also often leads to some side effects due to the inability to accurately control the ratio of the two medicines when taking them

Method used

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  • Aspirin ticlopidine compound preparation and preparation method thereof
  • Aspirin ticlopidine compound preparation and preparation method thereof
  • Aspirin ticlopidine compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The present embodiment provides aspirin ticlopidine compound preparation, and its prescription is as follows:

[0053] components Prescription amount Enteric-coated tablets aspirin 150mg microcrystalline cellulose 16.5mg corn starch 15mg Micropowder silica gel 0.75mg stearic acid 0.75mg Udage L30D-55 27mg gastric soluble shell Ticlopidine 300mg corn starch 150mg Hydroxypropyl Cellulose 14.25mg Sucrose Fatty Acid Ester 3.75mg Sodium carboxymethyl cellulose 15mg Magnesium stearate 4.5mg polyethylene glycol 6000 37.5mg

[0054] The preparation method of the present embodiment aspirin ticlopidine compound preparation:

[0055] (1) Mix aspirin with microcrystalline cellulose, cornstarch, micropowder silica gel, and stearic acid for 15 minutes in a three-dimensional mixer to obtain a mixed powder;

[0056] (2) Using a tablet press to compress the mixed powde...

Embodiment 2

[0064] The present embodiment provides aspirin ticlopidine compound preparation, and its prescription is as follows:

[0065] components Prescription amount Enteric-coated tablets aspirin 100mg microcrystalline cellulose 11mg corn starch 10mg Micropowder silica gel 0.5mg stearic acid 0.5mg Udage L30D-55 18mg gastric soluble shell Ticlopidine 200mg corn starch 100mg Hydroxypropyl Cellulose 9.5mg Sucrose Fatty Acid Ester 2.5mg Sodium carboxymethyl cellulose 10mg Magnesium stearate 3mg polyethylene glycol 6000 25mg

[0066] The preparation method of the present embodiment aspirin ticlopidine compound preparation:

[0067] (1) Mix aspirin with microcrystalline cellulose, cornstarch, micropowder silica gel, and stearic acid for 15 minutes in a three-dimensional mixer to obtain a mixed powder;

[0068] (2) Using a tablet press to compress the mixed powder to obtain...

Embodiment 3

[0076] The present embodiment provides aspirin ticlopidine compound preparation, and its prescription is as follows:

[0077] components Prescription amount Enteric-coated tablets aspirin 50mg microcrystalline cellulose 5.5mg corn starch 5mg Micropowder silica gel 0.25mg stearic acid 0.25mg Udage L30D-55 9mg gastric soluble shell Ticlopidine 100mg corn starch 50mg Hydroxypropyl Cellulose 4.75mg Sucrose Fatty Acid Ester 1.25mg Sodium carboxymethyl cellulose 5mg Magnesium stearate 1.5mg polyethylene glycol 12.5mg

[0078] The preparation method of the present embodiment aspirin ticlopidine compound preparation:

[0079] (1) Mix aspirin with microcrystalline cellulose, cornstarch, micropowder silica gel, and stearic acid for 15 minutes in a three-dimensional mixer to obtain a mixed powder;

[0080] (2) Using a tablet press to compress the mixed powder to obtain ...

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Abstract

The invention provides aspirin-ticlopidine compound preparation and a preparation method thereof. Aspirin ticlopidine compound preparation, comprising: an enteric-coated tablet core and a stomach-soluble shell, the active ingredient of the tablet core is aspirin, and the stomach-soluble shell wraps the outside of the enteric-coated tablet core A chip is formed; the stomach-soluble shell layer contains microparticles; the microparticles include polyethylene glycol on the surface and contents inside; the contents contain ticlopidine. In the aspirin-ticlopidine compound preparation of the present invention, the ticlopidine and the aspirin do not directly contact each other, avoiding the mutual interference of the two drug components, and improving the stability during storage.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an aspirin-ticlopidine compound preparation and a preparation method thereof. Background technique [0002] With the changes in people's living environment and eating habits, the incidence of cardiovascular and cerebrovascular diseases is increasing year by year. Anti-platelet aggregation is of great significance for the prevention and treatment of thrombosis and various cardiovascular and cerebrovascular diseases caused by it. Anti-platelet aggregation drugs currently on the market include aspirin, ticagrelor, and the combination of aspirin and clopidogrel. Studies have shown that when ticlopidine is used in combination with aspirin, it has a very good effect on anti-platelet aggregation. There is no compound preparation of ticlopidine and aspirin in the market at present. Patients need to take two kinds of medicines separately, which not only increases the cost of buying m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4365A61K31/616A61K9/30A61K47/10A61P7/02
CPCA61K31/4365A61K31/616A61K9/2853A61P7/02A61K2300/00
Inventor 李磊田兵徐凛威常衍武张超王娟
Owner NKD PHARMA CO LTD