Multicellular biological composite scaffold, preparation method and application thereof

A composite scaffold and biological technology, applied in tissue regeneration, prosthesis, additive processing, etc., can solve the problem that the treatment method cannot achieve complete, efficient, large-area repair of bone-cartilage defects, and achieve structural stability, structural integrity, small effect
CN112336920AActive Publication Date: 2021-02-09SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Publication Date
2021-02-09

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Abstract

The invention discloses a multicellular biological composite scaffold, a preparation method and application thereof. The scaffold comprises a lower-layer structure for forming a circular permutation mode of (A-B-A)m and an upper-layer structure for forming a circular permutation mode of (C-D-C)n, and A is a lower-layer composite material of bioactive ceramic powder containing three elements of Li,Mg and Si and an organic material with biocompatibility, B is stem cells with osteogenic differentiation potential, C is an upper-layer organic material containing an organic material with biocompatibility, D is chondrocyte, m and n are positive integers between 1 and 100. The multicellular biological composite scaffold can simulate the physiological structure of osteochondral complex tissue andefficiently promote the integrated repair of osteochondral defect.
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Description

technical field

[0001] The present invention relates to a biocomposite scaffold containing multi-cells and its preparation method and application, in particular to a structurally layered cell-containing inorganic-organic material composite bioactive scaffold, which can simulate the complex structure of bone-cartilage The structural and physiological environment can effectively promote the directional differentiation of bone-cartilage-related cells, and it is a potential therapeutic method for the treatment of bone-cartilage complex tissue defects. At the same time, it provides a preparation method of the above-mentioned composite scaffold, and the adhesion rate of cells on the composite scaffold is high, and the proliferation and differentiation activities are good. Belongs to the field of biotechnology. Background technique

[0002] In daily life, osteoarthritis, sports injuries, obesity and other reasons may cause joint bone-cartilage lesions or even defects. Due to the c...

Claims

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