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Application of yl-0919 in the preparation of drugs for anti-infection or infection-related diseases

A technology for 1. YL-0919 and disease, applied in the field of biomedicine, can solve problems such as low protein content, high drug resistance, and unsatisfactory antiviral drug effects, and achieve credible experimental results and favorable support effects

Active Publication Date: 2022-04-08
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure of the virus itself is simple, and the protein content is small. After long-term use of antiviral drugs, it has high drug resistance, which leads to the unsatisfactory effect of antiviral drugs commonly used in clinical practice.

Method used

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  • Application of yl-0919 in the preparation of drugs for anti-infection or infection-related diseases
  • Application of yl-0919 in the preparation of drugs for anti-infection or infection-related diseases
  • Application of yl-0919 in the preparation of drugs for anti-infection or infection-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 explores the effect of YL-0919 on anti-bacterial infection

[0048] 1. Experimental materials:

[0049] (1) Instruments: 25μL micro-sampler (Shanghai Anting Micro-sampler Factory), 5ml syringe, foam board, electronic weight scale (Beijing Kainuo Spring Biotechnology Co., Ltd.), constant temperature shaker THZ-C (Suzhou Pei British Experimental Equipment Co., Ltd.), low-speed centrifuge (Thermo Company), clean bench (Qingdao Haier Co., Ltd.), biological safety cabinet (Qingdao Haier Co., Ltd.), CO2 incubator (Thermo Company).

[0050] (2) Bacteria: Listeria monocytogenes (L.monocytogenes-OVA) (gifted by Professor Zhang Jiyan, Institute of Military Cognitive and Brain Science, Academy of Military Medical Sciences, Academy of Military Sciences).

[0051] (3) Drugs and main reagents: Brain Heart infusion Agar (BHIA) (Beijing Kainuo Spring Biotechnology Co., Ltd.), normal saline for injection (Sinopharm Chemical Reagent Co., Ltd.), dropiprone hydrochloride (YL -0...

Embodiment 2

[0072] Example 2 explores the effect of YL-0919 on antiviral infection

[0073] 1. Experimental materials and instruments: VSV (Peking Union Medical College Hospital), C57BL / 6 female mice of 6-8 weeks, micro syringe, sodium pentobarbital, drilling needle, stereotaxic apparatus, MC-5 micromanipulator.

[0074] 2. Experimental method

[0075] (1) Establishment of VSV viral encephalitis model

[0076] Use 1% pentobarbital sodium (8μL / g) to anesthetize the mouse. After 3-5 minutes, cut off the fur of the mouse's head to expose the head, and fix the mouse in a stereotaxic instrument with the anterior bregma as the center zero point , 1.2mm laterally, 0.7mm posterior to bregma, and 2mm deep, and then use an electric drill to drill a hole at the location, and then connect a microinjector to inject VSV virus (1×10 6 pfu / g), inject 2μL / 8min / mouse, after the injection, the syringe stays for 5min and then taken out.

[0077] a. Animal anesthesia: C57BL / 6 mice, female, weighing 18-20 g...

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Abstract

The invention discloses the application of YL-0919 in the preparation of medicines for resisting infection or infection-related diseases. Animal experiments have proved that YL‑0919 has a good anti-infection effect. The research results of the present invention provide new methods and ideas for clinical treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of YL-0919 in the preparation of drugs for resisting infection or infection-related diseases. Background technique [0002] Infectious diseases are diseases caused by pathogenic microorganisms such as viruses, chlamydia, mycoplasma, rickettsia, bacteria, spirochetes, fungi, and worms. So far, infection is still one of the main causes of human death and disability, and it is a major problem facing the medical community today. The emergence of some known or unknown infectious diseases seriously endanger human life and health, such as new coronavirus pneumonia (SARS-CoV-2), meningitis, viral hepatitis, bird flu, AIDS, etc. [0003] Anti-infective drugs refer to various antibiotics, sulfonamides, quinolones, and other chemically synthesized drugs that can kill or inhibit various pathogenic microorganisms and can be used orally, intramuscularly, intravenously, and other system...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4545A61P31/12A61P31/04A61P31/10A61P33/10A61P25/00A61P31/06A61P31/14
CPCA61K31/4545A61P31/12A61P31/04A61P31/10A61P33/10A61P25/00A61P31/06A61P31/14Y02A50/30
Inventor 李云峰韩根成张黎明鲍金豪代威冉玉华高扬李葛唐莉莉高振芳沈倍奋
Owner ACADEMY OF MILITARY MEDICAL SCI