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Tri-rare-earth fluorescence sensor capable of being used for recognizing human metabolites

A technology of trimesic acid and europium terbium, which is applied in the field of preparation of lanthanum trimesate, can solve the problem of fewer fluorescent sensors for uric acid and achieve accurate detection

Active Publication Date: 2021-02-19
SICHUAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there are few fluorescent sensors for the direct detection of uric acid

Method used

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  • Tri-rare-earth fluorescence sensor capable of being used for recognizing human metabolites
  • Tri-rare-earth fluorescence sensor capable of being used for recognizing human metabolites
  • Tri-rare-earth fluorescence sensor capable of being used for recognizing human metabolites

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] refer to Figure 13 , the preparation and application of three rare earth fluorescent sensors that can be used to identify human metabolites, the steps are as follows:

[0033] S1, select raw materials, lanthanum nitrate, terbium nitrate, europium nitrate and trimesic acid;

[0034] S2, dissolving trimesic acid in ethanol, stirring;

[0035] S3, first adding lanthanum nitrate solution to the solution obtained in S2, then adding different proportions of terbium nitrate and europium nitrate solutions, and stirring;

[0036] S4, standing still, centrifugal washing, drying to obtain a white sample;

[0037] S5, characterizing the obtained lanthanum trimesate materials with different doping amounts of europium and terbium;

[0038] S6, the use of europium-terbium-doped lanthanum trimesate for the detection of human metabolite uric acid.

[0039] Further, in both step S2 and step S3, stir at room temperature for 30 min.

[0040] Further, add europium ion mole fraction in...

Embodiment 2

[0067] The lanthanum trimesate material doped with europium and terbium of the present invention is used as a fluorescent probe to detect uric acid in urine.

[0068] Water Stability:

[0069] Such as Figure 5 Shown are the XRD pattern and the fluorescence emission spectrum pattern of the preferred sample immersed in water for different times. It is preferred that the sample has good pH stability after two weeks storage in water.

[0070] Such as Figure 6 Shown are the XRD patterns and fluorescence emission spectra of preferred samples immersed in different pH solutions. The preferred samples also exhibit good pH-independent luminescence and structural stability in the pH range of 3-10, indicating that the preferred samples have good compatibility with the aqueous environment. These results indicate that the preferred samples are promising for fluorescent sensors to detect specific human urine metabolites.

[0071] Optional test:

[0072] Figure 7 The effect of the v...

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Abstract

The invention relates to preparation of europium and terbium co-doped lanthanum trimellitate. The preparation method comprises the following steps: S1, selecting raw materials including lanthanum nitrate, terbium nitrate, europium nitrate and trimesic acid; S2, dissolving trimesic acid in ethanol, and performing stirring; S3, firstly adding a lanthanum nitrate solution into the solution obtained in the S2, then adding terbium nitrate and europium nitrate solutions in different proportions, and performing stirring; S4, standing, centrifugally washing and drying to obtain a white sample; S5, characterizing the obtained lanthanum trimellitate materials with different europium and terbium doping amounts; and S6, applying the europium-terbium-doped lanthanum trimellitate to detection of human metabolite uric acid. The rare earth material is a lanthanum trimellitate metal organic framework obtained by doping europium nitrate and terbium nitrate solutions, and is called as a tri-rare-earth fluorescent material for short. Due to the stable frame structure and the multiple emission peak characteristics of the material, the existence of the human metabolite uric acid can be more rapidly, accurately and directly detected in the water environment within the pH value range of urine.

Description

technical field [0001] The invention relates to the technical field of preparation of three rare earth metal organic framework materials, in particular to the preparation and application of lanthanum trimesate co-doped with europium and terbium. Background technique [0002] Uric acid (also known as 2, 6, 8-trihydroxypurine, referred to as UA) is one of the main products of purine (such as adenine, guanine) nucleotide metabolism in the human body. The metabolic process of uric acid in urine is that uric acid is first dissolved in the blood, then passed through the kidneys, and finally excreted through the urine. Uric acid is a weak acid (pK a =5.8), at physiological pH, it mainly exists in the form of urate. The normal range of uric acid in a healthy adult is: serum 0.13 ~ 0.46 mM, urine 1.49 ~ 4.50 mM. Abnormal levels of uric acid in the urine may increase the risk of diseases such as urethritis, gout, leukemia, severe hepatitis, chronic kidney disease, clotted mouth, an...

Claims

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Application Information

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IPC IPC(8): C08G83/00C09K11/06G01N21/64
CPCC08G83/008C09K11/06G01N21/6402C09K2211/182
Inventor 宁张磊李明凤杨洁冯莉
Owner SICHUAN NORMAL UNIVERSITY
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