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Hydroxyapatite coating on the surface of a corrosion-resistant medical magnesium alloy and its preparation method

A technology of hydroxyapatite and magnesium alloy, applied in metal material coating process, coating, vacuum evaporation plating and other directions, can solve the problems of stress shielding, unfavorable new bone growth, etc., and achieve the effect of improving corrosion resistance.

Active Publication Date: 2021-04-02
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional metal implants (such as stainless steel and titanium alloys, etc.) have certain disadvantages, that is, their elastic modulus is very different from that of natural bone, which is easy to cause stress shielding, which is not conducive to the growth of new bone

Method used

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  • Hydroxyapatite coating on the surface of a corrosion-resistant medical magnesium alloy and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Use 400#, 800#, and 1200# precision sandpaper to polish both sides and sides of a 10*10*1mm square sheet of AZ31B magnesium alloy until the surface is smooth without obvious scratches, and then use absolute ethanol, acetone, deionized Rinse separately with water for five minutes and dry with a hair dryer at best.

[0025] Place the magnesium alloy in the magnetron sputtering coating device, use hydroxyapatite as the magnetron sputtering target, the target-substrate distance is 40mm, the background vacuum is 5Pa, and the sputtering process is filled with argon gas. For protection, the sputtering power is 400W, and the sputtering time is 2 hours.

[0026] The hydroxyapatite bio-coating obtained by magnetron sputtering was heated up to 400°C at 10°C / min under atmospheric conditions, kept for 2h, cooled with the furnace, and then taken out.

[0027] Soak the heat-treated hydroxyapatite biological coating in liquid nitrogen at -196°C for cryogenic treatment, take it out aft...

Embodiment 2

[0029] Use 400#, 800#, and 1200# precision sandpaper to polish both sides and sides of a 10*10*1mm square sheet of AZ31B magnesium alloy until the surface is smooth without obvious scratches, and then use absolute ethanol, acetone, deionized Rinse separately with water for five minutes and dry with a hair dryer at best.

[0030] Place the magnesium alloy in the magnetron sputtering coating device, use hydroxyapatite as the magnetron sputtering target, the target-substrate distance is 40mm, the background vacuum is 5Pa, and the sputtering process is filled with argon gas. For protection, the sputtering power is 400W, and the sputtering time is 2 hours.

[0031] The hydroxyapatite bio-coating obtained by magnetron sputtering was heated up to 400°C at 10°C / min under atmospheric conditions, kept for 2h, cooled with the furnace, and then taken out.

[0032] Soak the heat-treated hydroxyapatite bio-coating in liquid nitrogen at -196°C for cryogenic treatment, take it out after 30 m...

Embodiment 3

[0034] Use 400#, 800#, and 1200# precision sandpaper to polish both sides and sides of a 10*10*1mm square sheet of AZ31B magnesium alloy until the surface is smooth without obvious scratches, and then use absolute ethanol, acetone, deionized Rinse separately with water for five minutes and dry with a hair dryer at best.

[0035] Place the magnesium alloy in the magnetron sputtering coating device, use hydroxyapatite as the magnetron sputtering target, the target-substrate distance is 40mm, the background vacuum is 5Pa, and the sputtering process is filled with argon gas. For protection, the sputtering power is 400W, and the sputtering time is 2 hours.

[0036] The hydroxyapatite bio-coating obtained by magnetron sputtering was heated up to 400°C at 10°C / min under atmospheric conditions, kept for 2h, cooled with the furnace, and then taken out.

[0037] Soak the heat-treated hydroxyapatite bio-coating in liquid nitrogen at -196°C for cryogenic treatment, take it out after 30 m...

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Abstract

The invention provides a hydroxyapatite coating on the surface of a corrosion-resistant medical magnesium alloy and a preparation method thereof. The hydroxyapatite coating prepared on the surface of a medical magnesium alloy by a magnetron sputtering method can effectively improve the corrosion resistance of the medical magnesium alloy. Corrosion performance, after the appropriate post-treatment process, put the above coating material in liquid nitrogen for cryogenic treatment, cryogenic treatment can further improve the corrosion resistance of magnesium alloy coating, 1-10 times of cryogenic treatment can make it resistant The corrosion performance is increased by 17‑49%, among which 6 cryogenic treatments are the best, making the magnesium alloy material suitable for more medical scenarios.

Description

technical field [0001] The invention relates to the field of a hydroxyapatite coating, in particular to a medical magnesium alloy hydroxyapatite coating and a preparation method thereof. Background technique [0002] Implantable biomedical metal materials have become the earliest medical materials implanted into organisms due to their excellent mechanical properties, compressive strength and corrosion resistance. They have been widely used in medicine, including artificial joints and cardiac pacemakers. , cardiovascular, renal valves and teeth, etc. However, pure medical metal materials will react with human tissues for a long time after being implanted in the human body, and even release toxic components, so a layer of biologically active coating, such as hydroxyapatite, is usually coated on the surface of the material. In this way, its corrosion resistance performance can be improved, and its application range in clinical medicine can be enhanced. [0003] Traditional me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/35C23C14/06C23C14/58A61L27/32
CPCA61L27/32C23C14/06C23C14/35C23C14/5806
Inventor 朱剑熹韩斐朱勇胡懿郃罗浩刘宇奇
Owner XIANGYA HOSPITAL CENT SOUTH UNIV