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A kind of preparation method of porous polymer semipermeable membrane and product thereof

A polymer semipermeable membrane and polymer technology, which is applied in the field of porous polymer semipermeable membrane preparation, can solve the problems of reducing the stability of the sensor, inconvenient membrane thickness, and difficulty in ensuring the consistency of the same batch.

Active Publication Date: 2022-08-09
DREISAM (BEIJING) MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This often requires us to go through multiple coatings to get the required thickness. At the same time, multiple coatings also bring inconvenience to the control of film thickness in production, making it difficult to guarantee the consistency of the same batch.
In addition, implantable biosensors often rub against surrounding soft tissues such as muscle and fat during use, and hydrophilic polymer films tend to have poor adhesion on the surface of hydrophobic biosensors, which will reduce the stability of the sensor. In severe cases, the semi-permeable membrane will fall off from the surface of the sensor

Method used

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  • A kind of preparation method of porous polymer semipermeable membrane and product thereof
  • A kind of preparation method of porous polymer semipermeable membrane and product thereof
  • A kind of preparation method of porous polymer semipermeable membrane and product thereof

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Embodiment 1

[0028] Embodiment 1 of the present invention: a preparation method of a porous polymer semipermeable membrane:

[0029] Poly-N-butyloxanorborneneimide (molecular weight is 100000g / mol) and pentaerythritol tetramercaptoacetate (molar ratio C=C:-SH=1:4) in tetrahydrofuran / n-butanol (V THF :V n-Butanol =1:4) Dissolve in the mixed solvent to form a coating solution (the mass percentage concentration of polymer poly-N-butyloxanorborneneimide is 10%); immerse the biosensor in the coating solution, 30°C Then, a layer of polymer film was coated on the electrode surface of the biosensor by the pulling method; dried at 30 °C for 60 minutes, the hydrophobic component and the hydrophilic component were separated during this process; the polymer film was subjected to UV cross-linking. , UV wavelength 365nm, energy density 25mW cm -2 After cross-linking, the biosensor was immersed in n-butanol for 1 minute to remove unreacted pentaerythritol tetramercaptoacetate, and dried at 30°C for 60 ...

Embodiment 2

[0030] Embodiment 2: A kind of preparation method of porous polymer semipermeable membrane:

[0031] (molecular weight is 50000g / mol) and (molar ratio C=C:-SH=1:20) in tetrahydrofuran / isopropanol (V THF :V iso-propanol =1:1) Dissolved in mixed solvent to form coating solution (polymer The mass percentage concentration of 10%); the surface of the biosensor electrode was coated with a doctor blade at 25 °C; dried at 30 °C for 30 minutes, the hydrophobic component and the hydrophilic component were separated during this process; The film is UV cross-linked, the UV cross-linking wavelength is 254 nm, and the energy density is 25 mW cm -2 , the cross-linking time was 6 minutes; after cross-linking, the sensor was immersed in ethanol for 1 minute to remove unreacted After drying at 30°C for 120 minutes again, a porous polymer semipermeable membrane with a thickness of 13 μm was obtained.

Embodiment 3

[0032] Embodiment 3: A kind of preparation method of porous polymer semipermeable membrane:

[0033] (molecular weight is 20000g / mol) and (molar ratio C=C:-SH=1:2) dissolved in isopropanol solvent to form a coating solution (polymer The mass percentage concentration of 2%); spin coating on the surface of the biosensor electrode at 20 °C; drying at 40 °C for 30 minutes, during this process, the hydrophobic component and the hydrophilic component are separated; The film was cross-linked by heating and cross-linked at 80 °C for 1 hour; after cross-linking, the sensor was immersed in ethanol for 10 seconds to remove unreacted After drying at 40° C. for 60 minutes, a porous polymer semipermeable membrane with a thickness of 350 nm was obtained.

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Abstract

The invention provides a method for preparing a porous polymer semipermeable membrane, which comprises dissolving and mixing a hydrophobic polynorbornene-based polymer and a hydrophilic small molecular cross-linking agent containing a thiol functional group in a solvent that can dissolve both at the same time , to obtain a coating solution; coat the surface of the biosensor electrode, dry, separate the hydrophobic and hydrophilic components, and then remove the unreacted hydrophilic small molecule cross-linking agent after film-forming and cross-linking, and dry again to obtain porous A polymer semipermeable membrane; products are also disclosed. In the product obtained by the preparation method of the invention, the hydrophobicity of the polymer enables the porous polymer semi-permeable membrane to have good adhesion on the surface of the biosensor, the porous structure ensures the diffusion of biological substances to the surface of the biosensor, and the thickness of the polymer membrane is not significantly changed. to regulate the diffusion rate of biological substances in semipermeable membranes.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a method for preparing a porous polymer semipermeable membrane and a product thereof. Background technique [0002] Polymer semipermeable membranes are crucial components of biosensors, especially implantable biosensors. Taking electrochemical biosensors as an example, the most important function of the polymer semipermeable membrane is to control the diffusion rate of biological substances from the external environment to the sensor electrode surface, because the linear response concentration range of the sensor is usually much smaller than the actual biological substance in the environment. concentration. For small molecular biological substances, the diffusion rate mainly depends on the hydrophilicity and thickness of the polymer semipermeable membrane: biological substances cannot diffuse in membranes with no or low hydrophilicity. After the water reaches a certain level...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/76B01D67/00G01N27/327
CPCB01D71/76B01D67/0006G01N27/327B01D2323/30B01D2325/38B01D67/0009B01D71/82B01D2323/345B01D2323/081B01D2323/02B01D2323/12B01D2323/36
Inventor 邹鹏
Owner DREISAM (BEIJING) MEDICAL TECH CO LTD
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