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Small molecule compound for treating lymphedema and application thereof

A small molecular compound, lymphedema technology, applied in the application field of medicine or health food, can solve problems such as difficult treatment and lack of safe and effective treatment drugs

Inactive Publication Date: 2021-03-05
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its treatment is very difficult, so far, there is still a lack of safe and effective therapeutic drugs

Method used

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  • Small molecule compound for treating lymphedema and application thereof
  • Small molecule compound for treating lymphedema and application thereof
  • Small molecule compound for treating lymphedema and application thereof

Examples

Experimental program
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Effect test

experiment example

[0017] Thirty clean C57 female mice of about 7-8 weeks were randomly divided into model group and notoginsenoside R1 group according to body weight, and another 10 wild-type mice (WT) with similar body weight as control group were taken as control group. The notoginsenoside R1 group was intragastrically administered with notoginseng saponin R1 20 mg / kg / d every day, and the Control group and the model group were intragastrically administered with the same amount of normal saline every day for 4 consecutive weeks. The swelling degree of the modeling area of ​​the tail of the mice was measured every three days. Such as figure 2 As shown, notoginseng saponin R1 can reduce the degree of tail swelling in mice and improve lymphatic reflux.

[0018] Detection of Notoginsenoside R1 on Lymphatic Return Function

[0019] After 4 weeks of intragastric administration, the mice were placed in an anesthesia machine. After isoflurane anesthesia, the tail and buttocks were depilated, and 10...

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PUM

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Abstract

The invention relates to a small molecule compound for treating lymphedema. The effective component of the small molecule compound is Notoginsenoside R1, and the effective action concentration of Notoginsenoside R1 is 0.01-1000 microns as a medicine for treating lymphedema. The Notoginsenoside R1 is mixed with pharmaceutically acceptable pharmaceutical excipients to form powder, ointment, powder,injection, water aqua, enteric sustained release preparation or injection. Animal experiments prove that the Notoginsenoside R1 can reduce the fibrous tissue thickness of C57 mice and improve the lymphatic circulation of lymphedema mice. The invention also discloses application of the Notoginsenoside R1 in preparation of medicines or health products for treating lymphedema.

Description

technical field [0001] The invention relates to a small molecular compound for treating lymphedema, and proposes the application of the compound in preparing various forms of drugs or health food for preventing and treating lymphedema. Background technique [0002] Lymphedema (lymphedema) refers to hyperplasia of subcutaneous fibrous connective tissue and fat hardening caused by repeated infection of soft tissue fluid in certain parts of the body. Its treatment is very difficult, so far, there is still a lack of safe and effective therapeutic drugs. Lymphedema depends on the course of the disease sooner or later, and the treatment principles are different. The most important is early treatment to prevent the development of lesions. Satisfactory results cannot be obtained in the treatment of advanced cases. Primary lymphedema is mainly treated symptomatically, and elastic bandages can be used locally. Finding safe and effective drugs for the treatment of lymphedema has bec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P7/10A23L33/10
CPCA61K31/704A61P7/10A23L33/10A23V2002/00A23V2200/30A23V2250/30
Inventor 梁倩倩王拥军徐浩侯彤刘洋王晓赟杨燕萍
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE