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A novel bt/ha biphasic piezoelectric bioceramic bone tissue engineering restoration and its preparation method

A technology of bone tissue engineering and bioceramics, which is applied in the field of 3D printing, can solve problems such as volume differences, damage to electromagnetic circuit connectivity, and loss of piezoelectricity.

Active Publication Date: 2021-12-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently BaTiO with bioelectric activity matching that of native bone 3 The content of non-degradable piezoelectric phase in calcium phosphate composite materials is as high as 80-90%. This is due to the low density of calcium phosphate, and the volume difference between bioceramics and piezoelectric ceramics of the same quality is very large. Accounting for more than 20%, the piezoelectric ceramic powder particles are completely dispersed by the bioceramic, destroying the BaTiO 3 The electromagnetic circuit connectivity of the phase, the material loses piezoelectricity (DUBEY A K, BASU B, BALANI K, et al. Dielectric and Pyroelectric Properties of HAp-BaTiO3 Composites[J]. Ferroelectrics,2011,423(63-76.)

Method used

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  • A novel bt/ha biphasic piezoelectric bioceramic bone tissue engineering restoration and its preparation method
  • A novel bt/ha biphasic piezoelectric bioceramic bone tissue engineering restoration and its preparation method
  • A novel bt/ha biphasic piezoelectric bioceramic bone tissue engineering restoration and its preparation method

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Embodiment 1

[0038] A preparation method of a novel BT / HA dual-phase piezoelectric bioceramic bone tissue engineering restoration (BT80 / HA60), comprising the following steps:

[0039]Weigh 5 grams of deionized water, then weigh 20.0 g of piezoelectric phase barium titanate (BT) and 0.2 gram of hydroxypropyl methylcellulose (1% of BT mass) and mix evenly, then add to the The measured deionized water is added and stirred until it is uniformly dispersed to obtain a piezoelectric phase slurry. Take by weighing 8.0 grams of deionized water again, then take by weighing 12.0 grams of bioactive phase hydroxyapatite (HA) and 0.20 grams of hydroxypropyl methylcellulose (1.7% of HA mass) and mix evenly, then divide into four batches Add it into the measured deionized water, and stir while adding until it is evenly dispersed by stirring to obtain a bioactive phase slurry. Then put the two kinds of slurry into two printing barrels, put the lid on and put it into an ultrasonic machine for 15 minutes, t...

Embodiment 2

[0041] A preparation method of a novel BT / HA dual-phase piezoelectric bioceramic bone tissue engineering restoration (BT80 / HA50), comprising the steps of:

[0042] Weigh 5 grams of deionized water, then weigh 20.0 grams of piezoelectric phase barium titanate (BT) and 0.3 grams of hydroxypropyl methylcellulose, mix them evenly, and then add them to the measured deionized water in four batches , stirring while adding until the stirring is evenly dispersed, and the piezoelectric phase slurry is obtained. Then weigh 8 grams of deionized water, then weigh 8.0g HA and 0.16 grams of hydroxypropyl methylcellulose and mix them evenly, then add them to the measured deionized water in four batches, and stir while adding until they are evenly mixed Disperse to obtain a bioactive phase slurry. Then put the two kinds of slurry into two printing cylinders, put the lid on and put it into an ultrasonic machine for 30 minutes, take it out and put it in a refrigerator at 4 degrees Celsius for 1...

Embodiment 3

[0044] A preparation method of a novel BT / HA dual-phase piezoelectric bioceramic bone tissue engineering restoration (BT60 / HA70), comprising the following steps:

[0045] Weigh 13.3 g of deionized water, then weigh 20.0 g of BT and 0.4 g of hydroxypropyl methylcellulose and mix them evenly, then add them to the measured deionized water in four batches, and stir while adding until they are evenly dispersed , to obtain the piezoelectric phase slurry. Then weigh 5.1 grams of deionized water, then weigh 12.0 grams of HA and 0.20 grams of hydroxypropyl methylcellulose and mix them evenly, then add them to the measured deionized water in four batches, and stir while adding until they are evenly mixed Disperse to obtain a bioactive phase slurry. Then put the two kinds of slurry into two printing cylinders, put the lid on and put it in an ultrasonic machine for 15 minutes, take it out and put it in a refrigerator at 8 degrees Celsius for 12 hours. Then put the static slurry into the...

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Abstract

The invention discloses a novel BT / HA biphase piezoelectric bioceramics bone tissue engineering prosthesis and a preparation method thereof. The method includes: separately preparing BT and HA slurries; designing a communication device to connect two printing barrels; printing piezoelectric bioceramics with a melt extrusion 3D printer (FDM) that can simultaneously print multiple barrels Bone tissue engineering scaffold; the printed scaffold is dried and sintered at high temperature in an air atmosphere to obtain a piezoelectric bioceramic scaffold. The beneficial effects of the present invention are as follows: 1. By using a communication device to connect two barrels containing different slurries, it is ensured that the same fiber extruded by the 3D printer has two continuous phases, which is different from the traditional single barrel. Compared with extrusion printing, a new composite method of two-component materials is created, so that the constructed scaffold has a new structure; 2. The content of HA / BT can be freely adjusted by adjusting the viscosity of the two slurries without destroying Piezoelectric phase continuity.

Description

technical field [0001] The invention relates to the field of 3D printing, in particular to a novel BT / HA dual-phase piezoelectric bioceramic bone tissue engineering restoration and a preparation method thereof. Background technique [0002] Human bone tissue is a special "piezoelectric material". The piezoelectric effect of bone tissue is roughly the same as that of piezoelectric materials, but the excitation method is different. Piezoelectric materials deflect the electrical axis of the material after being deformed by pressure, thereby generating charges. The bone tissue deflects the electrical axis of the bone tissue through the interaction and mutual reaction of various organic components, thereby producing piezoelectric effect. Previous research results suggest that negative charges can promote the proliferation and differentiation of osteoblasts, accelerate calcium deposition and promote bone healing. [0003] The development of bone substitute materials with the ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/468C04B35/636A61L27/12A61L27/42B33Y70/10A61L27/10
CPCC04B35/468C04B35/6365B33Y70/10A61L27/10A61L27/12A61L27/425C04B2235/3212C04B2235/6026C04B2235/6562C04B2235/6567A61L2430/02
Inventor 杭飞牛学涛钱天宝陈祥欣张明豪
Owner SOUTH CHINA UNIV OF TECH
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