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Coprophilous fungus freeze-drying protective agent and application thereof in coprophilous fungus transplantation

A technology of freeze-dried protective agent and fecal bacteria, which is applied in the field of fecal bacteria freeze-dried protective agent and its application in fecal bacteria transplantation, can solve the problems of inconvenient operation and damage to the fragile mucous membrane in the human cavity, and achieve convenient operation, The effect of protecting the activity and stabilizing the survival rate

Inactive Publication Date: 2021-03-12
FOSHAN LANGSEE BIOTECHNOLOGY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires the installation of an infusion catheter, which causes inconvenient operation and may damage the fragile mucous membrane in the human cavity
Adverse events caused by this have also been frequently reported

Method used

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  • Coprophilous fungus freeze-drying protective agent and application thereof in coprophilous fungus transplantation
  • Coprophilous fungus freeze-drying protective agent and application thereof in coprophilous fungus transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A freeze-drying protective agent for fecal bacteria is composed of the following components in terms of weight percentage: 5% trehalose, 5% mannitol, and the balance is sterile water.

[0018] Mix 10% fecal bacteria and 90% freeze-drying protective agent to obtain fecal bacteria liquid; freeze-dry the fecal bacteria liquid for 30 hours to obtain fecal bacteria freeze-dried powder.

Embodiment 2

[0020] A freeze-drying protective agent for fecal bacteria is composed of the following components in terms of weight percentage: 10% trehalose, 15% sucrose, and the balance is sterile water.

[0021] Mix 10% fecal bacteria and 90% freeze-drying protective agent to obtain fecal bacteria liquid; freeze-dry the fecal bacteria liquid for 32 hours to obtain fecal bacteria freeze-dried powder.

Embodiment 3

[0023] A freeze-drying protective agent for fecal bacteria is composed of the following components in terms of weight percentage: 15% trehalose, 25% maltodextrin, and the balance is sterile water.

[0024] Mix 10% fecal bacteria and 90% freeze-drying protective agent to obtain a fecal bacteria liquid; freeze-dry the fecal bacteria liquid for 34 hours to obtain a fecal bacteria freeze-dried powder.

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Abstract

The invention discloses a coprophilous fungus freeze-drying protective agent and application thereof in coprophilous fungus transplantation, and belongs to the technical field of biology. The coprophilous fungus freeze-drying protective agent is prepared from the following components: 5%-15% of trehalose, 5%-25% of edible substances and the balance of sterile water. Edible substances are adopted,through a reasonable formula, the survival rate of microorganisms in the freeze-dried powder can be stabilized, and the activity of intestinal flora can be protected; the freeze-dried powder technology is adopted, implementation of flora transplantation is facilitated, and operation is convenient.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a fecal bacteria freeze-drying protectant and its application in fecal bacteria transplantation. Background technique [0002] Fecal microbiota transplantation (FMT) refers to the transplantation of functional flora in the feces of healthy people into the gastrointestinal tract of patients to rebuild new intestinal flora and achieve the treatment of intestinal and extraintestinal diseases. As an effective means of rebuilding intestinal flora, fecal microbiota transplantation has been used in various bacterial flora-related diseases such as Clostridium difficile infection, inflammatory bowel disease, intractable constipation, metabolic disease, intestinal immune deficiency, and intestinal allergy. Disease treatment and exploratory research, and is considered a breakthrough medical progress in recent years. [0003] After the flora leaves the gut, its environment changes and its activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26A61K47/36A61K47/46A61K35/74A61K9/19A61P1/00
CPCA61K47/26A61K47/36A61K47/46A61K35/74A61K9/19A61P1/00
Inventor 张召马燕施琬陈涛
Owner FOSHAN LANGSEE BIOTECHNOLOGY CO LTD
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