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Cellulose red alga polysaccharide film coating premix and preparation method thereof

A red algae polysaccharide, film coating technology, applied in sugar-coated pills, pill delivery, pharmaceutical formulations and other directions, can solve the problems of surface wear, poor film strength, poor adhesion of finished products, etc. Choice, good appearance and performance

Inactive Publication Date: 2021-03-12
北京药源世纪生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the existing film-coating premixes, due to the unreasonable selection of polymers or unreasonable composition ratios, after the coating slurry is prepared, some of them have too low viscosity, resulting in the coating film of the solid pharmaceutical preparation coating finished product Poor adhesion to the core of the drug, surface wear of the finished product, cracking or peeling of the film edge, etc. There is a lot of aggregation on the surface of the drug to cause adhesion, and the density of the coating film is also poor, resulting in a lot of air bubbles; when the coating slurry is too difficult, it may also cause the surface of the coating layer of the final film coating product to be rough and wrinkled. ; When the drug core tablet with nicks or marks on the coating surface, if the composition of the coating premix is ​​unreasonable, the mechanical parameters of the coating film will be unreasonable, such as too high elastic coefficient, poor film strength, adhesion It is not easy to wait, and a high pullback force is generated during the drying process of the coating film, which pulls the surface of the coating film from the score, and the film retracts, resulting in bridging phenomenon, making the score on the drug surface disappear or the mark is unclear

Method used

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  • Cellulose red alga polysaccharide film coating premix and preparation method thereof
  • Cellulose red alga polysaccharide film coating premix and preparation method thereof
  • Cellulose red alga polysaccharide film coating premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh κ-carrageenan 0.4kg, iota-carrageenan 0.2kg, hypromellose 8.3kg.

[0041] The above-mentioned mixture by weight was mixed with a two-dimensional motion mixer for 25 minutes to prepare a film coating premix. Pour the mixed solution of ethanol and water with a mass ratio of 1:3 and the film coating premix into the liquid preparation tank, the quality of the mixed solution is 18 times that of the mixed raw materials. Raise the temperature to 85°C, add the premixing agent while stirring when the temperature is reached, and stir for 30 minutes, then cool down to 45°C, and stand at a constant temperature for 30 minutes; the stomach-soluble colorless transparent cellulose red algae polysaccharide film coating solution is obtained.

Embodiment 2

[0043] Weigh 1 kg of κ-carrageenan, 0.5 kg of iota-carrageenan, 2.5 kg of ethyl cellulose, and 6 kg of hypromellose.

[0044] The above-mentioned mixture by weight was mixed with a two-dimensional motion mixer for 35 minutes to prepare a film coating premix. Pour the mixed solution of ethanol and water with a mass ratio of 1:10 and the film coating premix into the liquid preparation tank, and the quality of the mixed solution is 24 times that of the mixed raw materials. Raise the temperature to 95°C, add the premixing agent while stirring when the temperature is reached, and stir for 30 minutes, then cool down to 55°C, and place at a constant temperature for 30 minutes; the stomach-soluble colorless transparent cellulose red algae polysaccharide film coating solution is obtained.

Embodiment 3

[0046] Weigh 0.8 kg of κ-carrageenan, 0.3 kg of iota-carrageenan, 1.6 kg of ethyl cellulose, 1.3 kg of sodium carboxymethyl cellulose, and 6 kg of hypromellose.

[0047] The above-mentioned mixture by weight was mixed with a two-dimensional motion mixer for 29 minutes to prepare a film coating premix. Pour the mixed solution of ethanol and water with a mass ratio of 1:10 and the film coating premix into the liquid preparation tank, and the quality of the mixed solution is 22 times that of the mixed raw materials. Raise the temperature to 83°C, add the premixing agent while stirring after reaching the temperature, and then cool down to 49°C after stirring for 20 minutes, and keep it at a constant temperature for 35 minutes; the stomach-soluble colorless transparent cellulose red algae polysaccharide film coating solution is obtained.

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Abstract

The invention relates to the field of drug coating, in particular to a cellulose red alga polysaccharide film coating premix and a preparation method thereof. The film coating premix is prepared fromthe following raw material components in parts by weight: 6-36 parts of red alga polysaccharide and 83-110 parts of cellulose derivative, or 6-36 parts of red alga polysaccharides, 83-110 parts of cellulose derivatives and 1-10 parts of auxiliary components. The red alga polysaccharides are kappa- carrageenan and iota-carrageenan; The cellulose derivative is selected from one or more of hydroxypropyl methylcellulose, ethyl cellulose and sodium carboxymethyl cellulose.

Description

[0001] This application is a divisional application with an application date of October 28, 2016, an application number of 201610964426.8, and an invention title of "A Cellulose Red Algae Polysaccharide Film Coating Premix and Its Preparation Method". The applicant is Beijing Yaoyuan Century Biotechnology Co., Ltd. technical field [0002] The invention relates to the field of drug coating, in particular to a cellulose red algae polysaccharide film coating premix and a preparation method thereof. Background technique [0003] The polymer solution or dispersion is evenly coated on the surface of solid preparations such as tablets, capsules, pellets, and granules to form a plastic film layer with a thickness of several microns. This process is called film coating. That is film coating. Film coating is a new type of coating technology developed by western countries in the early 1950s, and it has experienced more than half a century of development. my country started relativel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/36A61K47/02A61K47/10A61K9/30A61K9/28A61K9/36
CPCA61K9/2813A61K9/282A61K9/286A61K9/2866A61K47/38A61K47/36A61K47/02A61K47/10
Inventor 周玉坤唐思宇
Owner 北京药源世纪生物科技有限公司
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