A controllable porous bioceramic scaffold and its preparation method and application
A technology of bioceramics and porous structure, applied in ceramic products, applications, and other household appliances, etc., can solve the problems of high difficulty in manufacturing biological scaffolds, poor adaptability to the human body, and difficulty in porous structures, and achieve good biological activity and biocompatibility , good biological activity, good adhesion effect
Active Publication Date: 2022-04-22
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology
[0007] The traditional manufacturing of porous structures is relatively difficult, and there is a lack of processing methods for adjusting the human body adaptability of the manufactured bio-scaffolds, which makes the current bio-scaffolds difficult to manufacture, high in cost and poor in human body adaptability
Method used
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[0041] In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments, which are only used to explain the present invention, but should not be construed as limiting the present invention.
[0042] Embodiments of the present invention provide a method for preparing a controllable porous bioceramic support, such as figure 1 shown, including the following steps:
[0043] Step 1: using the computer three-dimensional drawing software Magics to draw a scaffold model with a porous structure;
[0044] Step 2: Divide the particle size to 40×10 3 nm calcium silicate powder and particle size is 50×10 3 nm magnesium hydroxide powder was weighed and mixed in a ratio of 90:10, and the planetary ball mill was used to mix evenly to obtain a mixed powder, wherein, the planetary ball mill was stirred for a total of 3 hours, forward rotation for 1 hour, s...
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Abstract
The invention provides a controllable porous bioceramic support and its preparation method and application. The preparation method includes the following steps: drawing a support model with a porous structure; mixing and stirring the bioceramic and a pore-forming agent to obtain a mixed powder; adding photosensitive resin and The dispersant is used to obtain the slurry; the slurry is put into the tank, and the slurry is printed into a green body; the green body is cleaned and the surface liquid is removed, and then degreased and sintered to obtain a bracket; the bracket is put into an acidic solution Soaking, cleaning with clean water after completion to obtain a stent; adding surface coating powder to the polyvinyl alcohol solution and stirring to obtain a coating material solution; putting the stent into the coating material solution to obtain a coating material attached to the surface bracket. The parameters of the shape, porosity and shape of the porous structure in the scaffold of the present invention are controllable, which can meet the individual requirements of implanting the scaffold; it has good bioactivity and biocompatibility, and is suitable as a material for bone repair.
Description
technical field [0001] The invention relates to the preparation technology of biological supports, in particular to a controllable porous bioceramic support and its preparation method and application. Background technique [0002] Bone tissue defect is a kind of injury with huge amount and serious harm to health. Bone defects resulting from trauma, surgery, congenital malformations, aging populations and other unique conditions are affecting the quality of life of millions of people around the world. In my country, the existing and annual increase of bone defects is huge, and there are more than 100 million osteoporosis patients in my country, and 30% of the elderly fractures are related to osteoporosis, and the number of new osteoporosis patients is about 3 million every year. Although human bone tissue has self-repair ability, it is difficult for bone tissue to achieve self-recovery when the bone defect reaches a certain critical value. Therefore, when there is a large s...
Claims
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IPC IPC(8): C04B38/06C04B35/22C04B35/622C04B35/638A61L27/56A61L27/54A61L27/34A61L27/30A61L27/10
CPCC04B38/0645C04B35/22C04B35/622C04B35/638A61L27/10A61L27/56A61L27/54A61L27/34A61L27/306C04B2235/6562C04B2235/6567C04B2235/3206A61L2430/02A61L2300/404C04B38/0074C04B38/0054
Inventor 沈理达张寒旭何志静刘富玺焦晨邱明波田宗军
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS