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Precursor compound of hexahydro-beta-acid component compound, feed composition and application thereof

A technology of precursor compounds and compounds, which is applied in the separation/purification of carbonyl compounds, the preparation of organic compounds, and the preparation of carbon-based compounds, etc., which can solve the problems affecting the use of products and the decrease of active ingredient content

Pending Publication Date: 2021-03-16
GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when hexahydrolupulone and hexahydrolupulone are used in finished feed products, the content of active ingredients decreases during storage, which affects the use of the product in the aquaculture industry

Method used

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  • Precursor compound of hexahydro-beta-acid component compound, feed composition and application thereof
  • Precursor compound of hexahydro-beta-acid component compound, feed composition and application thereof
  • Precursor compound of hexahydro-beta-acid component compound, feed composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] Preparation and purification of compounds

[0042] The preparation of the precursor compound of the hexahydro-β-acid component compound represented by the formula (I) involved in the present invention includes the following process:

[0043] (1) take commercial hop extract as raw material, obtain β-acid with organic solvent extraction and separation method;

[0044] (2) described β-acid prepares hexahydro-β-acid through hydrogenation reduction;

[0045] (3) The hexahydro-β-acid is prepared by recrystallization method or chromatographic separation method to obtain different hexahydro-β-acid component compounds, and the hexahydro-β-acid component compound is specifically six Hydrolupulone (I1-1), Hexahydrolupulone (I1-2) and Hexahydrolupulone (I1-3);

[0046] (4) The hexahydro-β-acid component compound is combined with a substituted or unsubstituted linear or branched fatty acid to undergo an esterification reaction to obtain a precursor compound of the hexahydro-β-acid...

Embodiment A 6

[0134] The semi-synthetic preparation method of the premise compound of embodiment A hexahydro-β-acid component compound

[0135] Those skilled in the art will recognize that other methods for preparing the hexahydro-beta-acid component compounds of the present application are considered to be within the scope of the present application. For example, the synthesis of non-exemplified hexahydro-beta-acid component compounds according to the present application can be successfully accomplished by those skilled in the art by modifying methods such as appropriate protection of interfering groups, by using other reagents or by changing the reaction conditions Make some general modifications.

[0136] Preparation of A1β-acid

[0137] Add 1kg of hops extract, 3L of pure water and 1L of ethanol in sequence to a 5L beaker, stir to dissolve the extract, add 0.5L of KOH alkaline solution dropwise to adjust the pH of the solution to 13, stand, and remove insoluble matter by suction filtra...

Embodiment B 6

[0186] Example B Preparation of Feed Compositions of Precursor Compounds of Hexahydro-β-Acid Component Compounds

[0187]The content of the precursor compound of the hexahydro-beta-acid component compound in the feed composition involved in the present invention is greater than or equal to 0.00001%, which can be determined according to the different growth stages of different animals or the product characteristics of the feed industry (such as feed additives). , feed additive raw materials, feed raw materials, etc.) can be used to adjust the content, and can also be adjusted according to the proportion of other nutrients and non-nutrients in different feed formulas to meet the needs of the feed formula. The following only takes the basic granular premix as an example to explain the feed composition of the present invention. Any similar formula or the replacement or increase of the non-synergistic effect of the formula components is regarded as the purpose of the present inventi...

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Abstract

The invention discloses a precursor compound of a hexahydro-beta-acid component compound, a feed composition and an application thereof. The invention relates to a precursor compound of a hexahydro-beta-acid component compound, or a solvate of the precursor compound and a feed acceptable salt, the structure of the precursor compound is shown as a formula (I), R1 is selected from substituted or non-substituted C1-C2 alkyl, and R2 or R3 is independently selected from H and substituted or unsubstituted straight-chain or branched-chain C2-C4 carbonyl. According to the invention, the fatty acid esterification precursor compound of the hexahydro-beta acid-component compound is found to have good stability under a high-temperature condition, and the problem of degradation of effective componentscaused by high-temperature granulation of the hexahydro-beta-acid component compound in a feed processing process is solved. Further, the invention also finds that the hexahydro-beta acid component compound propionate or butyrate and the feed acceptable salt or solvate thereof in the fatty acid esterification precursor compound of the hexahydro-beta acid component compound, not only can bear the high temperature course of feed processing, but also has the equivalent effect of the hexahydro-beta acid component compound when being applied to breeding.

Description

Technical field: [0001] The present application relates to the field of animal feed additives, in particular to a precursor compound of a hexahydro-beta-acid component compound and a feed composition comprising the precursor compound of the hexahydro-beta-acid component compound and its application. Background technique: [0002] Hop acid is an organic acid derived from hops, including α-acid and β-acid, which has the biological effect of bactericidal, bacteriostatic or changing metabolites, and can be used as a substitute for antibiotics in animal feed in the field of animal breeding. Among them, β-acid has stronger antibacterial activity. Hop acid has poor stability and solubility. In the past, it was usually added to animal feed for mixing, or prepared into a 1% concentration of potassium salt solution, sprayed and wrapped in feed or mixed for use. These forms of use are in It is extremely inconvenient to use in animal breeding and production. Studies have suggested tha...

Claims

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Application Information

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IPC IPC(8): C07C67/14C07C67/56C07C69/16C07C69/28C07C45/62C07C45/81C07C49/713C07C45/79C07C45/80C07C49/743A23K20/105
CPCC07C69/16C07C69/28C07C67/14C07C67/56C07C45/62C07C45/81C07C45/79C07C45/80A23K20/105C07C2601/16C07C49/743C07C49/713C07C2601/14A23K10/30A23K50/75A23K50/60A23K50/30
Inventor 彭险峰
Owner GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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