The invention discloses a synthesis process of 2, 2, 4-trimethyl-1, 3pentanediol dibutyrate and application of 2, 2, 4-trimethyl-1, 3pentanediol dibutyrate in interior wall latex paint. According to the method, 2, 2, 4-trimethyl-1, 3pentanediol and butyric acid are used as the raw materials for reaction in the presence of a catalyst to prepare 2, 2, 4-trimethyl-1, 3pentanediol dibutyrate. According to the invention, 2, 2, 4-trimethyl-1, 3pentanediol dibutyrate is used as a film-forming assistant to prepare paint for the first time, high film forming efficiency is achieved, the RTC-300 adding amount in a same formula can be reduced by 10% compared with RTC-16, and the boiling point of the 2, 2, 4-trimethyl-1, 3pentanediol dibutyrate is higher, therefore the environmental protection requirement of TVOC is met.