97 results about "Butyric acid ester" patented technology

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

The invention discloses a self-degradable granular temporary plugging agent for fracturing as well as a preparation method and application thereof, and relates to the technical field of oilfield chemistry. The temporary plugging agent is prepared by melting, blending and crushing the following materials in percentage by mass: 70%-85% of poly (3-hydroxybutyrate-co-4-hydroxybutyrate), 10%-20% of poly (3-hydroxybutyrate-co-4-hydroxybutyrate), 10%-20% of poly (3-hydroxybutyrate), 2%-10% of an auxiliary agent for assisting degradation; 10%-15% of nano silicon dioxide; 1%-7% of sodium starch glycolate. The temporary plugging agent disclosed by the invention contains the disintegrant glycolic acid starch sodium which is extremely high in water absorption capacity, and can rapidly absorb water and expand the volume of the temporary plugging agent by 250-300 times, so that the temporary plugging agent expands to generate cracks, on one hand, gaps among particles can be reduced after the temporary plugging agent absorbs water and expands in the early stage of plugging, and the compactness of a whole plugging layer is increased; on the other hand, cracks are generated on the surface of the temporary plugging agent after expansion, and water can permeate into temporary plugging agent particles from the cracks, so that the contact area between the temporary plugging agent and the water is increased, the degradation of the temporary plugging agent is promoted, and the overall degradation time is shortened.

The present invention discloses a self-degradable particle temporary plugging agent for fracturing and its preparation method and application, relating to the field of oilfield chemical technology. According to mass percentage, the temporary plugging agent is obtained by melt blending and crushing the materials including the following components: poly (3-hydroxybutyric acid-co-4-hydroxybutyrate), 70%-85%; auxiliary agent for auxiliary degradation, 2%~10%; nano silicon dioxide 10%~15%; sodium starch glycolate, 1%~7%. The temporary plugging agent of the present invention contains disintegrant sodium starch glycolate, which has a strong water absorption capacity and can quickly absorb water and expand its own volume by 250~300 times, so that the temporary plugging agent expands and cracks appear. On the one hand, in the early stage of plugging, the temporary plugging agent can reduce the gap between particles after absorbing water and expanding, thereby increasing the density of the entire plugging layer, thereby improving the plugging ability. On the other hand, cracks are generated on the surface of the temporary plugging agent after expansion, and water can penetrate into the interior of the temporary plugging agent particles from the cracks, which increases the contact area between the temporary plugging agent and water, thereby promoting its degradation and shortening the time of overall degradation.

The invention provides a polyhydroxyalkanoate composition as well as a preparation method and application thereof. The polyhydroxyalkanoate composition comprises at least two kinds of copolymers of 3-hydroxybutyrate and 4-hydroxybutyrate. The at least two copolymers of 3-hydroxybutyrate and 4-hydroxybutyrate at least comprise one segmented copolymer of 3-hydroxybutyrate and 4-hydroxybutyrate, and in the segmented copolymer, the mass percentage content of a 4-hydroxybutyrate structural unit is 0-20%; the at least two copolymers of the 3-hydroxybutyrate and the 4-hydroxybutyrate at least comprise a random copolymer of the 3-hydroxybutyrate and the 4-hydroxybutyrate. The polyhydroxyalkanoate composition has good strength and toughness, the post-brittleness is also obviously improved, and meanwhile, the polyhydroxyalkanoate composition also has good processability and migration resistance.

An antifungal composition including a first essential oil, and a second essential oil, where the composition is configured to reduce disease onset, pathogen spread, or a combination thereof. Further, an antifungal compound including one or more aroma compounds selected from 4-(4-hydroxyphenyl)-2-butanone, furaneol, ethyl methylphenylglycidate, ethyl hexanoate, ethyl butanoate, beta-ionone, alpha-ionone, (R)-(+)-limonene, (S)-(-)-limonene, cis-3-Hexen-1-ol, nerol, linalool, 2-heptanone, alpha-terpineol, beta-damascenone, β-caryophyllene, ethyl 2-methylbutanoate, β-myrcene, gamma-octalactone, alpha-humulene, nerolidol, (E,E)-2,4-decadienal, (E,E)-α-farnesene, vanillin, phenylethyl acetate, citral, 3-methylbutan-1-ol, or a combination thereof.

The invention discloses a preparation process of rebamipide tablets, and relates to the technical field of pharmaceutical preparations. When preparing rebamipide tablets, the present invention first reacts BOC-lysine tert-butyl ester hydrochloride with isocyanoethyl methacrylate to obtain lysine monomer; lysine monomer is reacted with terminal 2-bromoisobutyrate polylactic acid to obtain an amino acid amphiphilic block copolymer; amino acid amphiphilic block copolymer is used to load rebamipide to obtain a loaded rebamipide amphiphilic copolymer; dopa is reacted with chitosan to obtain dopa-modified chitosan; dopa-modified chitosan and bismuth salt are film-coated on the surface of the loaded rebamipide amphiphilic copolymer to obtain dopa-modified chitosan-coated rebamipide, and then dopa-modified chitosan-coated rebamipide is made into tablets to obtain rebamipide tablets. The rebamipide tablets prepared by the present invention have the advantages of mucosal adhesion, long in vivo retention time, and high cellular uptake.

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and / or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

The invention discloses a method for preparing D-3-hydroxybutyric acid, which comprises the following steps: adding D-3-hydroxybutyrate into a food-grade sodium hydroxide aqueous solution with the concentration of not higher than 1.2 M, and stirring at the temperature of not higher than 45 DEG C to carry out hydrolysis reaction until the hydrolysis is finished to obtain a sodium D-3-hydroxybutyrate aqueous solution; in the D-3-sodium hydroxybutyrate aqueous solution, controlling the temperature to be not higher than 45 DEG C, adding food-grade hydrochloric acid which is equivalent to sodium hydroxide, and carrying out neutralization reaction, so as to obtain a D-3-hydroxybutyric acid aqueous solution; and carrying out reduced pressure distillation on the reaction liquid until crystallization, cooling to 5 DEG C, growing the crystal, separating, and drying to obtain the D-3-hydroxybutyric acid crystal. The invention also discloses ketogenic effervescent tablets containing D-3-hydroxybutyric acid as an active component and a preparation method thereof.

Compositions and methods for providing a person with an exogenous and therapeutically effective supply of ketones are disclosed. The compositions may consist essentially of (a) purified butyrate (or esters or propionate salts thereof) and (b) purified beta-hydroxybutyrate (or esters or propionate salts thereof). The compositions may further include other pharmacologically active agents, such as acetyl-L carnitine, R-alpha lipoic acid, green tea extract, vitamins, and various combinations of such agents. The methods include providing a person with an exogenous supply of ketones, by orally administering a pharmacologic composition, which is effective to deliver 2000-5000 mg of a short chain fatty acid (e.g., butyrate) and 5000-10,000 mg of ketone (e.g., beta-hydroxybutyrate) on a daily basis.

The application discloses a non-oxidative weak-acid polyacrylamide degrading agent and a preparation and use method thereof, and the degrading agent comprises the following components: a reducing agent, a regulator, a mutual solvent and water; the reducing agent is one of 3-O-ethyl ascorbic acid ether and L-ascorbic acid-2,6-dibutyrate; the regulator is ammonium chloride; and the mutual solvent is one of ethylene glycol monobutyl ether and isopropyl alcohol. The problems that the existing degrading agent needs to be isolated by a plug for redox reaction with subsequent injected mud acid or secondary precipitation is caused by metal ions such as Na + , K + , Fe 2+ and the like in the degrading agent and subsequent injected mud acid are effectively solved.

The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.

The invention discloses a preparation method and application of a bio-based polyester porous membrane, an organic solvent is used as a poly-3-hydroxybutyrate-co-4-hydroxybutyrate solvent, water is used as a non-solvent, and a phase inversion method is adopted to prepare the porous membrane. By adjusting the concentration of the membrane casting solution and the temperature of the coagulating bath, the phase separation behavior in the membrane forming process is regulated and controlled, the poly-3-hydroxybutyrate-co-4-hydroxybutyrate porous membrane with a controllable structure is prepared, and the porous membrane is uniform in pore distribution and high in porosity. The preparation method of the green polymer porous membrane material, provided by the invention, has the advantages of low cost, simple method, easiness in operation, energy conservation, environment friendliness and the like, and has a wide application prospect in the fields of oil-water separation, lithium ion batteries and the like; the problems of non-uniform pore size distribution, poor repeatability and the like of the existing polyhydroxyalkanoate in the phase separation film forming process are solved.

A process for preparing 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester, in which 1 mole of 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester is reacted with 2.0 to 2.2 moles of chloromethylenedimethyliminium chloride or more than 2.2 to 5 moles of chloromethylenedimethyliminium chloride to prepare a by-product in the form of 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid alkyl ester. The alkyl ester can be hydrolyzed to form 4-[5-[bis(2-chloroethyl)amino]-4-formyl-1-methyl-1H-benzo[d]imidazol-2-yl]butyric acid, which can be used in the pharmaceutical field.

The invention relates to the technical field of compatilizers, and particularly discloses a P34HB-g-GMA compatilizer as well as a preparation method and application thereof. The P34HB-g-GMA compatilizer is prepared from the following preparation raw materials in percentage by mass: 88%-98% of poly (3-hydroxybutyrate-4-hydroxybutyrate), 0.02%-2% of an initiator, 1%-10% of glycidyl methacrylate, 0.1%-1% of an inhibitor, 0.1%-1% of a lubricant and 0.1%-1% of an auxiliary agent, wherein the sum of the mass percentages of the preparation raw materials is 100%. The P34HB-g-GMA, which is prepared by carrying out addition reaction on GMA serving as a grafting monomer and free radicals on a P34HB molecular chain, has the property of a compatilizer, and can be used for effectively improving the compatibility between PHA and other biological materials and improving the stability and the mechanical property of the composite material when being applied to a biodegradable composite material.

To provide a synthesis method for preparing a chemical compound.SOLUTION: A process for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a] isoquinoline-2-yl 2-amino-3-methyl butanoate di(4-methylbenzene sulfonate) or its solvation, a hydrate or a polymorph is provided in the present specification. In other embodiments, these methods provide (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a] isoquinoline-2-yl 2-amino-3-methyl butanoate di(4-methylbenzene sulfonate) having purity exceeding 95%.SELECTED DRAWING: None

The application relates to the technical field of biomaterials, and particularly discloses a PHA combined microsphere as well as a preparation method and application thereof. The PHA combined microsphere provided by the application contains 10-40 wt% of PHA microspheres with a weight average molecular weight of less than 30000 Da and 1-40 wt% of PHA microspheres with a weight average molecular weight of more than 100000 Da, with the PHA being selected from one or more of poly-beta-hydroxybutyric acid, a copolymer of 3-hydroxybutyric acid ester and 3-hydroxyvaleric acid ester, a copolyester of 3-hydroxybutyric acid and 3-hydroxyhexanoic acid and poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid). After the PHA combined microsphere is filled in the skin, on one hand, the PHA combined microsphere can be rapidly degraded in an early stage and promote the reproduction of fibroblasts and endothelial cells in a short time; on the other hand, the PHA combined microsphere can be continuously degraded within 21 weeks and cannot cause inflammation, so that the effect of persistent filling is achieved.

The invention belongs to the technical field of lubricating oil, and particularly relates to a reinforcing agent composition for improving the friction performance of No.8 hydraulic transmission oil and application. The reinforcing agent composition is prepared from the following raw materials: ethyl pyrimiphos, 2-amino-2-oxy-1-(3-phenoxy phenyl) ethyl] 2-(4-dodecylbenzene)-3-methyl butyrate, a dispersing agent and base oil A. The invention further discloses a preparation method of the reinforcing agent composition. According to the invention, a compound system of ethylpyrimidinphosphorus and 2-amino-2-oxy-1-(3-phenoxy phenyl) ethyl] 2-(4-dodecyl-phenyl)-3-methylbutyrate is adopted, so that the friction performance is excellent, the friction performance of the hydraulic transmission oil 8 # can be improved, the test requirements of an Allison C-4 paper-based friction bench are met, and the friction performance of the hydraulic transmission oil 8 # is improved. And the device can adapt to different hydraulic transmission oil formula systems.

The invention discloses a bupivacaine-containing pharmaceutical composition and a preparation method and application thereof.The pharmaceutical composition comprises bupivacaine, sucrose acetate isobutyrate, benzyl alcohol and a stabilizer.The bupivacaine preparation has good stability and a long-acting analgesic effect, the preparation process is simple, and the preparation method is suitable for industrial production. The method is suitable for large-scale production.

A fragrance composition containing a compound represented by Formula (1) as an active ingredient:where in Formula (1), R1 represents a chain hydrocarbon group having from 7 to 20 carbons, and may be linear or branched, and a saturated group or an unsaturated group, and when R1 is an unsaturated group, R1 may have one or more carbon-carbon double bond(s) or carbon-carbon triple bond(s).

The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and / or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to now crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.

Provided herein are methods for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutyrate di(4-methylbenzenesulfonate) or a solvate, hydrate, or polymorph thereof.

The application provides a preparation method of 4-(hydroxymethyl phosphinyl)-2-oxobutanoic acid, comprising the following steps: a) adding 4-halogen-2-oxobutanoate into dialkyl methyl phosphite dropwise and controlling the temperature to be-30-40 DEG C, and performing a reaction under vacuum to obtain an intermediate liquid; b) mixing the intermediate liquid obtained in the step a) with an acid, performing a hydrolysis reaction, and then performing a purification treatment to obtain 4-(hydroxymethyl phosphinyl)-2-oxobutanoic acid. Compared with the prior art, the preparation method provided by the application uses dialkyl methyl phosphite and 4-halogen-2-oxobutanoate as raw materials, utilizes the SN2 intramolecular rearrangement mechanism, can realize high-efficiency construction of a P-C bond, and the one-step yield of the Arbuzov reaction can be more than 95%, and the final target product 4-(hydroxymethyl phosphinyl)-2-oxobutanoic acid can be obtained through subsequent acidic hydrolysis of the skeleton structure, and the overall yield can be close to 90%; compared with other methods, the preparation method provided by the application is simple in steps, has few reaction by-products, and has a great improvement in yield.

Provided is a conductive paste for forming an internal electrode used in a laminated ceramic electronic component, the conductive paste being capable of improving adhesion by suppressing sheet erosion and reducing the hardness of a dry film. The conductive paste includes a conductive metal powder, a ceramic powder, a binder resin, an additive, and an organic solvent including (A) and (B). (A) is at least one selected from the group consisting of dihydroterpineol acetate, isobornyl acetate, isobornyl propionate, isobornyl butyrate, and isobornyl isobutyrate, and (B) is at least one selected from the group consisting of ethylene glycol monobutyl ether acetate and dipropylene glycol methyl ether acetate. The additive contains more than 0% by mass and 2.0% by mass or less of a phosphoric acid polyester with respect to the total amount of the conductive paste.

A foodstuff can include a free acid β-hydroxybutyrate, and a base. The β-hydroxybutyrate, and base, are present at a less than 1:1 molar equivalence. Ketone Ester may also be incorporated as a component of the foodstuff.

The application discloses cupriavidus capable of producing polyhydroxyalkanoate by using various carbon sources such as ethanol and application thereof. Cupriavidus The strain sp.ZWJ01 has a preservation number of CGMCC No.37462 in the China General Microbiological Culture Collection Center. The strain can grow and accumulate poly-3-hydroxybutyric acid ester by using various substances such as ethanol, volatile fatty acid and sugar as carbon sources; can grow by using mixed carbon sources of ethanol+propionic acid or ethanol+valeric acid and accumulate poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid ester) in cells; and can grow by using mixed carbon sources of ethanol+gamma-butyrolactone or ethanol+1,4-butanediol and accumulate poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) in cells, and has a good application prospect.

Compositions for improving metabolic function in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. S-beta-hydroxybutyrate in pure or enriched form provides energy to the heart, dilates the arteries, decreases blood pressure and systemic vascular resistance, and increases cardiac output. S-Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. S-Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and provide one or more electrolytes. S-Beta-hydroxybutyrate esters provide more controlled release without adding electrolytes. Compositions for improving heart function in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

To provide a perfume composition for deodorization capable of deodorizing all of feces and urine odor, food odor and body odor without generating chemical odor.SOLUTION: The perfume composition for deodorization contains the following components (A) and (B), wherein the mass ratio [(B) / (A)] of the component (B) to the component (A) is 0.12 or more. (A) an aromatic ring-free unsaturated aldehyde having a molecular weight of 100 to 160 and 9 to 10 carbon atoms, and (B) one or more selected from the group consisting of 2-methyl-2-pentenoic acid, cis-3-hexenyl benzoate, citronellyl butyrate, benzaldehyde, trans-3-hexenol, cis-6-none-1-ol, and thymol SELECTED DRAWING: None

Provided are: a food or drink containing glucosylceramide in which the odor of glucosylceramide is masked despite containing a relatively large amount thereof and a suitable flavor is maintained; and a method for improving the flavor of the food or drink. The food or drink contains glucosylceramide and at least one substance selected from the group consisting of isobutyl acetate, ethyl butyrate, isoamyl acetate, trans-2-hexenal, and benzaldehyde. The method for improving the flavor of the food or drink containing glucosylceramide includes a step in which at least one substance selected from the group consisting of isobutyl acetate, ethyl butyrate, isoamyl acetate, trans-2-hexenal, and benzaldehyde is added to the food or drink containing glucosylceramide.

Compositions and methods for providing a person with an exogenous and therapeutically effective supply of short chain fatty acids and turmeric extracts (and / or curcuminoids) are disclosed. The compositions include purified butyrate and dried turmeric extracts. The compositions may optionally include purified butyrate and dried turmeric extracts spiked with additional curcumin I, curcumin II, and / or curcumin III. Alternatively, the compositions may include short chain fatty acids (such as butyrate) and purified curcumin I, curcumin II, and / or curcumin III.