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Electrochemical sensor for detecting glucose and preparation method thereof

An electrochemical and glucose technology, applied in the direction of scientific instruments, instruments, measuring devices, etc., can solve the problems of expensive equipment, cumbersome operation, and limit further application, achieve good stability and reproducibility, and improve the effect of electrocatalysis

Active Publication Date: 2021-03-16
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, a variety of methods for the detection of glucose have been proposed. Although these methods exhibit certain advantages, they generally involve disadvantages such as complicated sample pretreatment, long time-consuming, cumbersome operations, consumption of large amounts of organic reagents, and expensive equipment.
These disadvantages greatly limit their further application

Method used

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  • Electrochemical sensor for detecting glucose and preparation method thereof
  • Electrochemical sensor for detecting glucose and preparation method thereof
  • Electrochemical sensor for detecting glucose and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite material, the preparation method of the electrochemical sensor is as follows:

[0026] (1) Preparation of cobalt@nickel-metal organic framework: 0.375 mmol of Co(NO 3 ) 2 , 0.375 mmol of Ni(NO 3 ) 2 and 0.75 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent (32 mL of N.N-dimethylformamide, 2 mL of ethanol and 2 mL of secondary water) for sonication. The resulting product was sealed in a reactor and heated at 200 °C for 24 h. Then the reactor was cooled to room temperature, and the solid was collected and washed several times with secondary water. Finally, the resulting solid was dried overnight at 60 °C to obtain cobalt@nickel-MOF powders.

[0027] (2) Preparation of cobalt@nickel-metal-organic framework-graphene: 5.0 mg / mL graphene and 8 mg / mL cobalt@nickel-metal-organic framework were added to water, and 40 KHz ...

Embodiment 2

[0031]Example 2: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite, the preparation method of the electrochemical sensor is: 0.275 mmol of Co(NO 3 ) 2 , 0.275 mmol of Ni(NO 3 ) 2 and 0.55 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent, the concentration of graphene was 3.0 mg / mL, the concentration of cobalt@nickel-metal organic framework was 5 mg / mL, and the amount of dispersion liquid drop-coated on the surface of glassy carbon electrode 5 μL. All the other methods are with the method described in Example 1.

Embodiment 3

[0032] Example 3: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite, the preparation method of the electrochemical sensor is: 0.475 mmol of Co(NO 3 ) 2 , 0.475 mmol of Ni(NO 3 ) 2 and 0.85 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent, the concentration of graphene was 7.0 mg / mL, the concentration of cobalt@nickel-metal organic framework was 10 mg / mL, and the amount of dispersion liquid drop-coated on the surface of glassy carbon electrode 15 μL. All the other methods are with the method described in Example 1.

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Abstract

The invention belongs to the technical field of preparation of electrochemical electrode materials, and provides an electrochemical sensor for detecting glucose and a preparation method thereof. The electrochemical sensor is an electrochemical sensor based on cobalt@nickel-metal organic framework-graphene (CNMs-GR), and the sensor is used for simultaneously detecting glucose in human serum. The sensor shows high sensitivity and selectivity, the electrode modification process is simpler and more convenient, and good stability and reproducibility are achieved. Based on a cobalt@nickel-metal organic framework-graphene (CNMs-GR) nano composite material, a bimetallic framework is synthesized through a simple hydrothermal reaction, and the cobalt@nickel-metal organic framework-graphene CNMs-GR nano composite material is prepared. The sensitivity of the electrode is improved; and the electrode modification process is simpler. The electrochemical sensor is used for constructing a sensing system for detecting glucose in human serum, and the selectivity of the electrode is remarkably improved. The detection limit is 0.087 [mu]mol / L. The linear range is wide and the sensitivity is high.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrochemical electrode materials, and specifically relates to an electrochemical sensor for detecting glucose and a preparation method thereof. The electrochemical sensor is an electrochemical sensor based on cobalt@nickel-metal organic framework-graphene (CNMs-GR). sensor for the simultaneous detection of glucose in human serum. Background technique [0002] Glucose is an essential biomolecule directly involved in metabolic activities in the human body as it produces carbon dioxide and energy (ATP) through oxidation processes. However, high concentrations of glucose in the human blood can cause damage to human health, which can lead to diabetes and other complications. If left unchecked, diabetes can endanger a person's physical condition, causing disability and even death. According to reports, 415 million people face serious diabetes problems, while 193 million people with diabetes ...

Claims

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Application Information

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IPC IPC(8): G01N27/327C09D187/00C09D7/61C08G83/00
CPCG01N27/3277G01N27/3278C09D187/00C09D7/61C08G83/008C08L3/04C08L3/02
Inventor 雷鹏周影双少敏董川
Owner SHANXI UNIV
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