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Preparation method and application of biomineral composite hydrogel

A composite hydrogel and mineral technology, applied in the field of biomedical engineering, can solve problems such as self-healing and non-shape hydrogel

Inactive Publication Date: 2021-03-19
SHENZHEN TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Schmidt et al. prepared highly scalable elastic nanocomposite hydrogels by mixing polyethylene glycol and hydroxyapatite nanoparticles; however, due to the chemical crosslinking of the polyethylene glycol network, the hydrogels were not shapeable and unable to heal

Method used

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  • Preparation method and application of biomineral composite hydrogel
  • Preparation method and application of biomineral composite hydrogel
  • Preparation method and application of biomineral composite hydrogel

Examples

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preparation example Construction

[0017] The embodiment of the present invention provides a preparation method of biomineral composite hydrogel, which comprises the following steps:

[0018] S01: dissolving the polyelectrolyte and soluble calcium salt in water to obtain a mixed solution, wherein the weight average molecular weight of the polyelectrolyte is 800-600000, and the mass ratio of the polyelectrolyte to the soluble calcium salt is 5-0.5:1, The concentration of the soluble calcium salt is 1-50g / L;

[0019] S02: According to the calcium ion and phosphate molar concentration ratio of 1-2:1, drop the soluble phosphate solution into the mixed solution at a rate of 0.01-5 mL / min to obtain a reaction solution, the soluble phosphate solution The concentration is 0.05~2M;

[0020] S03: Stir the reaction solution for 15-60 minutes, wash the product, and obtain the biomineral composite hydrogel.

[0021] In step S01, the polyelectrolyte is polyacrylic acid (PAA), polymethacrylic acid, polystyrenesulfonic acid,...

Embodiment 1

[0030] Weigh 2.88g of PAA (Mw=450000) and 2.22g of CaCl 2 Prepare 200mL of mixed solution. Take 30mL of the mixed solution in a beaker, stir at a speed of 900rpm / min, and slowly drop in 0.1M K 2 HPO 4 solution, continue to stir for 30 min until the system is stable. The product is washed with deionized water to obtain a biomineral composite hydrogel.

Embodiment 2

[0032] Weigh 2.96g of polyacrylamide salt (Mw=450000) and 2.22g of CaCl 2 Prepare 200mL of mixed solution. Take 30mL of the mixed solution in a beaker, stir at 900rpm / min, and slowly drop in 0.1M K 2 HPO 4 solution, continue to stir for 30 min until the system is stable. The product is washed with deionized water to obtain a biomineral composite hydrogel.

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Abstract

The invention provides a preparation method of biological mineral composite hydrogel. The preparation method comprises the following steps that: polyelectrolyte and soluble calcium salt aredissolved in water to obtain a mixed solution, the weight-average molecular weight of the polyelectrolyte is 800-600000, the mass ratio of the polyelectrolyte to the soluble calcium salt is (5-0.5): 1, and the concentration of the soluble calcium salt is 1-50g / L; a soluble phosphate solution is dropwise added into the mixed solution at the speed of 0.01-5mL / min according to the molar concentration ratio of calcium ions to phosphate of (1-2): 1 to obtain a reaction solution, the concentration of the soluble phosphate solution ranges from 0.05 to 2M; and the reaction solution is stirred for 15-60 minutes,and a product is washed, so that the biological mineral composite hydrogel can be obtained. The invention also provides application of the biomineral composite hydrogel obtained by the preparation method in the fields of drug delivery, tissue engineering or stimulation response devices.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a preparation method and application of a biomineral composite hydrogel. Background technique [0002] Hydrogels are three-dimensional interconnected network-like materials that have attracted extensive attention due to their properties of high water content, hydrophilicity, softness, and biocompatibility. [0003] Incorporation of mineral particles into hydrogel matrices or crystalline minerals grown in situ in hydrogels can lead to nanocomposite hydrogels with good mechanical properties or novel structures, but their gel properties largely depend on the polymer matrix itself. For example, Schmidt et al. prepared highly scalable elastic nanocomposite hydrogels by mixing polyethylene glycol and hydroxyapatite nanoparticles; however, due to the chemical crosslinking of the polyethylene glycol network, the hydrogels were not shapeable and It cannot heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/02C08L33/26C08K3/16A61K47/02A61K47/32A61L27/02A61L27/12A61L27/16A61L27/50A61L27/54
CPCC08J3/075A61K47/02A61K47/32A61L27/12A61L27/16A61L27/54A61L27/50A61L27/025C08J2333/02C08J2333/26C08K2003/162A61L2430/02A61L2300/112A61L2300/412C08L33/02C08L33/26
Inventor 韩雨来邵锜许振东孙茜
Owner SHENZHEN TECH UNIV