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External-use medicament for lowering blood sugar and preparation method thereof

A technology for lowering blood sugar and medicaments, which is applied in the field of external medicaments for lowering blood sugar and its preparation, which can solve the problems of ineffective control of ulcer wounds, accelerated necrotic tissue shedding, and limited therapeutic effect, so as to promote dry gangrene wound healing and prevent drug The effect of evaporative loss and promoting drug absorption

Inactive Publication Date: 2021-03-26
管晓坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drug regimens are usually used for patients with diabetic foot dry gangrene. Western medicine treats diabetic foot dry gangrene mostly with antibiotics or various high-efficiency excipients for anti-inflammatory and anti-infective treatment of ulcer wounds, and the use cycle is long , and the function is single, the therapeutic effect is relatively limited, and it is easy to make patients rely on drugs. At the same time, chemical drugs composed of western medicine will also strongly stimulate the body, produce toxic and side effects, and have poor safety
Existing traditional Chinese medicines for external use are generally used to disinfect and sterilize, improve microcirculation, accelerate the shedding of necrotic tissue, and repair ulcer wounds, but there is a problem that they cannot effectively control ulcer wounds and promote wound healing. Hypoglycemic topical medicine for gangrene ulcer wound healing, to relieve patients' pain and reduce the probability of amputation

Method used

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  • External-use medicament for lowering blood sugar and preparation method thereof
  • External-use medicament for lowering blood sugar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2 and 6

[0036] Embodiment 2 and 6 external medicine preparation steps are as follows:

[0037] The preparation steps are as follows:

[0038] S1, drying the above-mentioned traditional Chinese medicine at 80°C, pulverizing, and passing through an 80-mesh sieve to obtain a dry powder of the traditional Chinese medicine, which is set aside;

[0039] S2, grind the calamine and pass through an 80-mesh sieve to obtain calamine powder for subsequent use;

[0040] S3, put the Chinese medicine dry powder into the extraction container, add 90% ethanol with a volume fraction of 10 times the weight of the Chinese medicine dry powder, soak for 6 hours, then reflux extract the soaked Chinese medicine dry powder twice, the first time for 5 hours, and the second time Secondary extraction for 3 hours, combining the two extracts, filtering the extract, and concentrating to a relative density of 1.3 to obtain a concentrated extract of traditional Chinese medicine;

[0041] S4, adding calamine powder ...

Embodiment 4 and 8

[0052] Embodiment 4 and 8 external medicine preparation steps are as follows:

[0053] The preparation steps are as follows:

[0054] S1, drying the above-mentioned traditional Chinese medicine at 75°C, pulverizing, and passing through a 70-mesh sieve to obtain a dry powder of the traditional Chinese medicine, which is set aside;

[0055] S2, grind the calamine and pass through an 80-mesh sieve to obtain calamine powder for subsequent use;

[0056] S3, put the Chinese medicine dry powder into the extraction container, add 90% ethanol with a volume fraction of 10 times the weight of the Chinese medicine dry powder, soak for 6 hours, then reflux extract the soaked Chinese medicine dry powder twice, the first time for 5 hours, and the second time Secondary extraction for 2 hours, combining the two extracts, filtering the extract, and concentrating to a relative density of 1.2 to obtain a concentrated extract of traditional Chinese medicine;

[0057] S4, adding calamine powder a...

Embodiment 9 and 10

[0060] Embodiment 9 and 10 external medicine preparation steps are as follows:

[0061] The preparation steps are as follows:

[0062] S1, drying the above-mentioned traditional Chinese medicine at 60-80°C, pulverizing, passing through a 60-80 mesh sieve to obtain a dry powder of Chinese medicine, and set aside;

[0063] S2, grind the calamine and pass through a 60-80 mesh sieve to obtain calamine powder for subsequent use;

[0064] S3, put the Chinese medicine dry powder into the extraction container, add 70-90% ethanol with a volume fraction of 6-10 times the weight of the Chinese medicine dry powder, soak for 4-6 hours, and then reflux the soaked Chinese medicine dry powder twice, the first The first extraction is 4-5 hours, the second extraction is 2-3 hours, the two extracts are combined, the extracts are filtered, and concentrated to a relative density of 1.2-1.3 to obtain a concentrated Chinese medicine extract;

[0065] S4, adding calamine powder and additives to the...

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Abstract

The invention provides an external-use medicament for lowering blood sugar and a preparation method thereof. The external-use medicament comprises traditional Chinese medicine components, and the traditional Chinese medicine components comprise appendiculate cremastra pseudobulb, Chinese wolfberry root-bark, germinated barley, belvedere fruit, himalayan teasel root, herba speranskiae tuberculatae,siberian cocklebur fruit, tribulus terrestris, dwarf lilyturf tuber, Chinese magnoliavine fruit, Myoporum bontioides, Polygonum orientale L., common bletilla rubber, twotoothed achyranthes root, Lupinus micranthus and Chinese small Iris root. According to the invention, external-use hydrogel is prepared by adding additives capable of promoting drug absorption into traditional Chinese medicine extract capable of promoting wound healing, so as to achieve the effects of lowering blood sugar and promoting dry gangrene wound healing, and the problems that internal-use medicines have side effects on the body, and the existing external-use traditional Chinese medicines can not effectively control dry gangrene ulcer wounds are effectively solved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an external drug for lowering blood sugar and a preparation method thereof. Background technique [0002] Diabetic foot refers to the reduction of lower limb function caused by neuropathy in the body's feet. Its microvessels and macrovascular lesions lack perfusion of a single artery, and microcirculation disturbances cause ulcers and gangrene. It is one of the serious complications of diabetes. The clinical manifestations of diabetic foot patients are intermittent claudication, foot pain, muscle atrophy, dry skin, decreased sensation, etc., which affect the normal life of patients. Dry gangrene mostly occurs in diabetic patients with atherosclerosis of extremity arteries and small arteries, severe stenosis of blood vessel lumen; or arterial thrombosis, resulting in obstruction of blood vessel lumen, blood flow is gradually or suddenly interrupted, but venous blood flow is still unblocked...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61K9/06A61K47/02A61K47/32A61P3/10A61P17/02A61K33/30
CPCA61K9/0014A61K9/06A61K33/30A61K36/185A61K36/21A61K36/28A61K36/47A61K36/48A61K36/57A61K36/704A61K36/79A61K36/80A61K36/815A61K36/88A61K36/8968A61K36/898A61K36/8998A61K47/02A61K47/32A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P3/10A61P17/02A61K2300/00
Inventor 管晓坤
Owner 管晓坤
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