Space full-automatic multifunctional bioreactor based on microsatellite

A bioreactor and multi-functional technology, applied in the direction of specific-purpose bioreactor/fermenter, bioreactor/fermenter combination, enzymology/microbiology device, etc., can solve the problem that microsatellites cannot carry human and cell biology The reactor cannot meet the requirements of microsatellites and other issues

Active Publication Date: 2021-03-30
TSINGHUA UNIV
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Problems solved by technology

[0014] (1) Microsatellites are light in weight and small in size, which requires the miniaturization of internal experimental devices. Traditional cell bioreactors on land or space stations can no longer meet the requirements of microsatellites
[0015] (2) Microsatellites cannot carry people, so experiments on microsatellites require high intelligence and automation

Method used

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  • Space full-automatic multifunctional bioreactor based on microsatellite

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Embodiment 1

[0047] This embodiment provides a space fully automatic multifunctional tumor stem cell bioreactor based on microsatellites, such as figure 1 As shown, the bioreactor integrates the first liquid culture unit 100 for tumor stem cell renewal and proliferation, the second liquid culture unit 200 for stem cell drug resistance research, and the first hydrogel three-dimensional culture for stem cell migration research Cell multifunctional culture module of unit 300 and the second hydrogel three-dimensional culture unit 400 for stem cell invasion research.

[0048] Preferably, the first liquid culture unit 100 is composed of a plurality of first cell suspension culture units 108 preferably cascaded or connected in series. The second liquid culture unit 200 is composed of a plurality of second cell suspension culture units 208 cascaded or connected in series. Each of the first cell suspension culture unit 108 and the second cell suspension culture unit 208 is provided with a liquid i...

Embodiment 2

[0060] This embodiment discloses an experimental method for tumor stem cells based on microsatellites, which integrates the first liquid culture unit 100 for tumor stem cell renewal and proliferation, the second liquid culture unit 200 for stem cell drug resistance research, and the second liquid culture unit 200 for stem cell migration research. The cell multifunctional culture module of the first hydrogel three-dimensional culture unit 300 and the second hydrogel three-dimensional culture unit 400 used for stem cell invasion and vascularization research simultaneously conduct self-renewal and proliferation, drug resistance, migration and invasion experiments of stem cells .

[0061] Preferably, the first liquid culture unit 100 and the second liquid culture unit 200 are inoculated with cells on the ground, and the cells are input into the culture units until they are full. After the satellite enters orbit, self-renewal, proliferation and drug resistance experiments are carrie...

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Abstract

The invention relates to a space full-automatic multifunctional bioreactor based on a microsatellite. The bioreactor is provided with a cell multifunctional culture module with integration of a firstliquid culture unit for tumor stem cell renewal and proliferation, a second liquid culture unit for tumor stem cell drug resistance research, a first gel culture unit for tumor stem cell migration research and a second gel culture unit for stem cell invasion and induced vascularization research. Experiments related to tumor stem cell function research are integrally designed in a small-size microbioreactor, and unmanned operation and data collection of multiple groups of experiments are realized through full-automatic remote sensing control. A cell liquid inlet channel, a culture medium liquid inlet channel and a waste liquid discharge channel of each culture unit are integrally designed for each liquid culture unit, so that space automatic liquid change can be realized. The hydrogel three-dimensional culture unit is uniformly provided with an automatic trace sample adding gun, so that space automatic sample adding is realized.

Description

technical field [0001] The invention relates to the technical field of space bioengineering, in particular to a space fully automatic multifunctional bioreactor based on microsatellites. Background technique [0002] Cancer stem cells, also known as cancer stem cells, refer to cells in tumors that have the ability to self-renew and generate heterogeneous tumor cells. Cancer stem cells play an important role in tumor formation, progression, recurrence and metastasis. Cancer stem cells are different from normal tumor tissue cells. Cancer stem cells differentiate slowly, but are resistant to many physical and chemical injuries (such as radiotherapy and chemotherapy), and studies have proved that chemotherapy and radiotherapy can also promote the proliferation of tumor stem cells. Cancer stem cells are considered to be the source of tumor recurrence after treatment. Therefore, it is of vital significance and value to study cancer stem cells and develop drugs targeting cancer ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/02C12M3/06C12M3/00C12M1/36C12M1/34
CPCC12M23/16C12M23/58C12M29/00C12M29/04C12M29/26C12M33/04C12M37/04C12M37/02C12M41/48C12M41/46
Inventor 熊卓张婷张艳梅复兴武鲁冰川
Owner TSINGHUA UNIV
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