Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation process and quality control method of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract

A quality control method and preparation technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems restricting application and promotion, and achieve the effect of ensuring stability, rapid and efficient quality control

Active Publication Date: 2021-03-30
SICHUAN NEO GREEN PHARMA TECH DEV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the research and development of modern Chinese medicine preparations, the inconvenience and uncertainty in the efficacy of traditional decoction methods have become more and more prominent, and have greatly affected and restricted the application and promotion of Chinese medicine preparations in the market. In order to maximize the efficacy of medicines, reduce toxic and side effects, and meet the clinical requirements of traditional Chinese medicine, it is the key to improve the extraction process of traditional Chinese medicine preparations and establish exclusive quality control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation process and quality control method of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract
  • Preparation process and quality control method of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract
  • Preparation process and quality control method of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] This example proposes the preparation process of the lotus root control extract.

[0097] Take 100g of lotus root decoction slices, add water to decoct twice, add 9 times of water to the first decoction (the height of the decoction slices should be 2-5cm below the liquid surface), soak for 30 minutes, first boil with strong fire, then switch to slow fire for 30 minutes, Use a 200-mesh sieve to filter while it is hot, and the filtrate is quickly cooled to room temperature in a cold water environment; add 7 times the water for the second decoction (the height of the liquid surface should be 2 to 5 cm), first boil it with a strong fire, and then switch to a slow fire. For 20 minutes, use a 200-mesh sieve to filter, combine the water decoction, and quickly cool the filtrate to room temperature in a cold water environment. Under ~60% environment, according to the batch of decoction, quickly collect powder (the range of powder collection rate should be 5.0-10.0%), weigh, pack...

Embodiment 2

[0136] This example relates to the preparation of 18 batches of lotus root control extracts. According to the preparation process described in Example 1, 18 batches of lotus root medicinal materials were taken to prepare the lotus root control extract.

[0137] 1. source

[0138] Collect 18 batches of lotus root medicinal materials from Shuangliu in Sichuan, Shiyan in Hubei, Xixiang in Henan and other production areas, and process them according to the selection method in Example 1. Since the 18 batches of lotus root medicinal materials have been processed at the place of origin to remove impurities, washed, and dried, and almost no impurities exist in the medicinal materials, the medicinal materials of lotus root joints can be regarded as decoction pieces at the place of origin at the same time, and used as raw materials for the preparation of control extracts.

[0139] The above 18 batches of medicinal materials all meet the requirements of the 2015 edition of the Chinese P...

Embodiment 3

[0161] This example is a quality control method for the lotus root control extract. Of course, this quality control method can also be applied to the quality control of the lotus root formula granules or its single Chinese medicine preparation.

[0162] 1. Experimental instruments and materials

[0163] High performance liquid chromatography: Agilent 1260 high performance liquid chromatography, Waters e2695 high performance liquid chromatography, Shimadzu 20AD high performance liquid chromatography;

[0164] Electronic balance: ME204E / 02, MS205DU, XP26 (Mettler-Toledo Instrument Co., Ltd.);

[0165] Ultrapure water machine: cell type 1810A (Shanghai Mole Scientific Instrument Co., Ltd.);

[0166] Ultrasonic cleaner: KQ-600DB type (600W, 40KHz; Kunshan Ultrasonic Instrument Co., Ltd.);

[0167] Chromatographic column: ZORBAX Eclipse XDB-C18 Analytical 4.6×250mm 5-Micron, Diamonsil 5μm C18(2) 250×4.6mm, XBridge C18 5μm 4.6×250mm, Kromasil 100-5-C18 4.6×250mm.

[0168] 2. Reag...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
particle sizeaaaaaaaaaa
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation process and a quality control method of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract. The preparation process comprises the following stepsof respectively processing rhizoma nelumbinis to obtain rhizoma nelumbinis and rhizoma nelumbinis charcoal decoction pieces, adding water, decocting twice, adding 9 times of water in one decoction, soaking for 30 minutes, boiling, keeping slight boiling, decocting for 30 minutes, filtering, and immediately cooling to room temperature, adding 7 times of water, boiling, keeping slight boiling, decocting for 20 minutes, filtering, combining water decoctions, cooling to room temperature, and carrying out vacuum freeze drying to obtain the rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract. By reasonably controlling the decocting times, the water adding amount, the decocting time and the like, the powder yield and the content of total polyphenol serving as an effective component of the powder can be effectively controlled, the stability of rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract components is guaranteed, and the process is stable in operation. Meanwhile, a specific chromatogram of the rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract and a determination method of the total polyphenol content of the rhizoma nelumbinis and rhizoma nelumbinis charcoal contrast extract are established, and quality control of stability and reliability of a preparation process of the rhizoma nelumbinis and rhizoma nelumbinis charcoal contrastextract can be realized.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations and detection, and in particular relates to a preparation process and a quality control method of lotus root and charcoal control extracts of lotus root. Background technique [0002] With the research and development of modern Chinese medicine preparations, the inconvenience and uncertainty in the efficacy of traditional decoction methods have become more and more prominent, and have greatly affected and restricted the application and promotion of Chinese medicine preparations in the market. In order to maximize drug efficacy, reduce toxic and side effects, and meet the clinical requirements of traditional Chinese medicine, it is the key to improve the extraction process of traditional Chinese medicine preparations and establish exclusive quality control. [0003] The lotus root joints are made from the dried rhizome joints of Nelumbo nucifera Gaertn., a plant of the water...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/74G01N30/86
CPCG01N30/02G01N30/06G01N30/74G01N30/8634
Inventor 周厚成胡昌江钟磊张开元刘珂汪席敏
Owner SICHUAN NEO GREEN PHARMA TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com