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Pharmaceutical composition and application thereof in preparing medicine for improving insulin resistance and reducing blood sugar

A technology of insulin resistance and composition, applied in the field of medicine, can solve the problem of insulin resistance without berberine and isoliquiritigenin, and achieve the effect of synergistically improving insulin resistance and improving insulin resistance

Active Publication Date: 2021-04-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no report that berberine and isoliquiritigenin can synergistically improve insulin resistance

Method used

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  • Pharmaceutical composition and application thereof in preparing medicine for improving insulin resistance and reducing blood sugar
  • Pharmaceutical composition and application thereof in preparing medicine for improving insulin resistance and reducing blood sugar
  • Pharmaceutical composition and application thereof in preparing medicine for improving insulin resistance and reducing blood sugar

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0018] 1. Experimental materials

[0019] 1. Experimental animals

[0020] Male C57BL / 6J mice, 7-8 weeks old, weighing about 18-22g, source: Zhejiang Weitong Lihua Experimental Animal Technology Co., Ltd. (SCXK (Zhejiang) 2019-0001).

[0021] 2. Experimental reagents

[0022] Berberine hydrochloride (Chengdu Master Biotechnology Co., Ltd., product number A0151, purity ≥ 98%, Lot#MUST-20073011); isoliquiritigenin (Chengdu Master Biotechnology Co., Ltd., product number A0463, purity ≥ 98%, Lot#MUST-20031903); metformin (MCE company, product number HY-17471A, Lot#29902); D-Glucose (U.S. Amresco company, product number 0188-1Kg, Lot#3277C100); bovine insulin powder (Biosharp, product number BS901, Lot# #69116301), Sodium Chloride Injection (Shuanghe Pharmaceutical). High-f...

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Abstract

The invention discloses a pharmaceutical composition and application of the pharmaceutical composition in preparing a medicine for improving insulin resistance and reducing blood sugar. It is found that berberine hydrochloride and isoliquiritigenin with the mass ratio of 3: 1 have the activity of synergistically reducing blood sugar and synergistically improving insulin resistance, the effect that1 + 1 is larger than 2 is achieved, and the composition formed by berine hydrochloride and isoliquiritigenin can be used for preparing medicine for reducing blood sugar and improving insulin resistance.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition and its medical application, in particular to a pharmaceutical composition and its application for preparing medicines for improving insulin resistance and lowering blood sugar. Background technique [0002] Insulin resistance (IR) refers to the situation that under the action of normal doses of insulin, the biological effect of the target tissue is lower than that of healthy people, and it is also known as "decreased insulin sensitivity". IR is one of the main pathophysiological features of type 2 diabetes mellitus (T2DM), and is widely present in metabolic diseases such as obesity, nonalcoholic fatty liver disease (NAFLD), hypertension, hyperlipidemia, and polycystic ovary syndrome (PCOS) middle. Insulin mainly acts on peripheral tissues (muscle, fat) and liver, and can promote the uptake and utilization of glucose by skeletal muscle and adipose tissue in the ...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/122A61P5/50A61P3/10
CPCA61K31/4375A61K31/122A61P5/50A61P3/10A61K2300/00
Inventor 杨华李萍郑祖国余玲玲高雯王可可
Owner CHINA PHARM UNIV
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