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Low-swelling-rate polymer medical hydrogel and preparation method thereof

A polymer and swelling rate technology, applied in medical science, prosthesis, etc., can solve problems such as limitations, achieve convenient operation, easy industrialized large-scale production, and improve the effect of strength and swelling

Active Publication Date: 2021-04-02
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hydrogel has its unique advantages as a biomaterial, the application of traditional hydrogel in biomedicine is limited due to the inevitable swelling under physiological conditions (Science, 2014, 343: 873)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a low-swelling polymer medical hydrogel, comprising the following steps:

[0023] (1) Preparation of carboxylated bacterial cellulose: Clean the bacterial cellulose membrane with deionized water, soak it with 0.3mol / L NaOH solution after cleaning, wash it with deionized water until neutral after soaking, and then cut it , put in 0.05mol / L phosphate buffer solution with pH=6.86 for hydrolysis for 2h, then adjust the pH to 5, add TEMPO with a concentration of 1.0mol / L, and NaClO with a concentration of 0.8mol / L 2 And concentration is the LNaClO of 0.1mol / , wherein the quality of TEMPO is 3% of bacterial cellulose quality, NaClO 2 The mass of NaClO and NaClO are both 65% of the mass of bacterial cellulose, react at 50°C for 2 hours, filter, wash, and dry after terminating the reaction to obtain carboxylated bacterial cellulose;

[0024] (2) the carboxylated bacterial cellulose is placed in pH 6.0, and the concentration is in the phosphate buffer so...

Embodiment 2

[0028] A preparation method of a low-swelling polymer medical hydrogel, comprising the following steps:

[0029] (1) Preparation of carboxylated bacterial cellulose: Clean the bacterial cellulose membrane with deionized water, soak it with 0.3mol / L NaOH solution after cleaning, wash it with deionized water until neutral after soaking, and then cut it , put in 0.05 mol / L, PH=6.86 phosphate buffer for hydrolysis for 3 hours, then adjust the pH to 5.5, add TEMPO with a concentration of 1.0 mol / L, and NaClO with a concentration of 0.8 mol / L 2 And concentration is the LNaClO of 0.1mol / , wherein the quality of TEMPO is 4% of bacterial cellulose quality, NaClO 2 The mass of NaClO and NaClO are both 72% of the mass of bacterial cellulose, react at 55°C for 1.5h, filter, wash and dry after the reaction is terminated to obtain carboxylated bacterial cellulose;

[0030] (2) the carboxylated bacterial cellulose is placed in pH 6.5, and the concentration is in the phosphate buffer solutio...

Embodiment 3

[0034] A preparation method of a low-swelling polymer medical hydrogel, comprising the following steps:

[0035] (1) Preparation of carboxylated bacterial cellulose: Clean the bacterial cellulose membrane with deionized water, soak it with 0.3mol / L NaOH solution after cleaning, wash it with deionized water until neutral after soaking, and then cut it , put in 0.05mol / L phosphate buffer solution with pH=6.86 for hydrolysis for 4h, then adjust the pH to 6, add TEMPO with a concentration of 1.0mol / L, and NaClO with a concentration of 0.8mol / L 2And concentration is the LNaClO of 0.1mol / , wherein the quality of TEMPO is 5% of bacterial cellulose quality, NaClO 2 The mass of NaClO and NaClO are both 80% of the mass of bacterial cellulose, react at 60°C for 1 hour, filter, wash and dry after terminating the reaction to obtain carboxylated bacterial cellulose;

[0036] (2) the carboxylated bacterial cellulose is placed in pH 7.0, and the concentration is in the phosphate buffer solut...

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PUM

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Abstract

The invention belongs to the technical field of preparation of medical hydrogel, and provides low-swelling-rate polymer medical hydrogel and a preparation method thereof. The preparation method comprises the following steps: (1) uniformly stirring carboxylated bacterial cellulose, N,N'-diisopropylcarbodiimide and 2,2'-dithiodiethanol diacrylate to obtain a uniform viscous solution; (2) adding a photoinitiator benzoin ethyl ether into the viscous solution, performing irradiation radiation polymerization under an ultraviolet high-pressure mercury lamp, and treating for 1-3h at the temperature of60-70 DEG C after the lamp is turned off, so as to obtain coarse gel; and (3) standing the coarse gel at room temperature, and performing washing to obtain the low-swelling-rate polymer medical hydrogel. According to the preparation method, carboxylated bacterial cellulose and N,N'-diisopropylcarbodiimide are subjected to acylation polycondensation, and meanwhile, a cross-linking agent 2,2'-dithiodiethanol diacrylate is used for cross-linking, so that the obtained hydrogel has a relatively low swelling rate and good biocompatibility, and can be used for narrow parts of organisms.

Description

technical field [0001] The invention relates to the technical field of medical hydrogel preparation, in particular to a high molecular medical hydrogel with low swelling rate and a preparation method thereof. Background technique [0002] Polymer hydrogel is a multi-component system composed of three-dimensional polymer network and water, which can produce huge changes in macroscopic (volume) shape in response to environmental stimuli. Since hydrogel is a kind of polymer material similar to living tissue, it has good biocompatibility, does not affect the metabolic process of living organisms, and metabolites can be discharged through hydrogel, so it can be used as a tissue filler. It is widely used in tissue engineering scaffold materials, and also plays an irreplaceable role in the controllable delivery of drugs and proteins and the study of the interaction between cells and biomaterials. [0003] As a polymer network structure, hydrogel will absorb a large amount of water...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/52A61L27/58C08J3/075C08J3/24C08L1/08C08K5/372
CPCA61L27/20A61L27/52A61L27/58C08J3/075C08J3/24C08B15/06C08J2301/08C08K5/372C08L1/08
Inventor 梁飞苟兴春姚琳余丽丽李伟泽
Owner XIAN MEDICAL UNIV