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Polyacrylamide glycyl glycinamide hydrogel and preparation method thereof

A technology of polyacryloylglycylglycinamide and acryloylglycylglycinamide is applied in the field of polyacrylglycylglycylglycinamide hydrogel and its preparation, and can solve the problems affecting the performance of hydrogel, Affecting problems such as polymer structure, to achieve the effect of high yield, high product purity, and mild reaction conditions

Active Publication Date: 2021-04-09
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This acryloylglycylglycylglycylamide also has multiple hydrogen bonding interactions, but the added amide groups also affect the structure of the polymer, which in turn affects the performance of the hydrogel

Method used

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  • Polyacrylamide glycyl glycinamide hydrogel and preparation method thereof
  • Polyacrylamide glycyl glycinamide hydrogel and preparation method thereof
  • Polyacrylamide glycyl glycinamide hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Disperse 1.5g of N-acryloylglycine in 200mL of dichloromethane, keep stirring in an ice bath, add 3g of dicyclohexylcarbodiimide to the above solution after 20min, stir for 20min, then add 1.6g of N-hydroxysuccinimide, reaction 6h. After the reaction is finished, the solid insoluble matter is filtered off, and the filtrate is taken for the next step of reaction. Add 0.5g glycinamide hydrochloride to the filtrate obtained in the previous step, add 0.7mL triethylamine to dissolve glycinamide hydrochloride, stir and react at room temperature for 12h, then filter, and the filtered solid is the target product propylene Acylglycylglycylglycylamide monomer.

[0025] Dissolve 0.05g of acryloylglycylglycylglycylamide monomer in 0.15mL of dimethyl sulfoxide (DMSO) / water (dimethyl sulfoxide (DMSO) / water=1 / 5, V / V) In a mixed solvent, a solution was obtained. Add 0.001 g of thermal initiator ammonium persulfate to the solution, move the mixed solution into a mold and polymerize a...

Embodiment 2

[0028] Take 3g of N-acryloylglycine and disperse it in 400mL of dichloromethane, keep stirring in an ice bath, add 5g of dicyclohexylcarbodiimide to the above solution after 40min, stir for 40min, then add 4.2g of N- Hydroxysuccinimide, reaction 10h. After the reaction is finished, the solid insoluble matter is filtered off, and the filtrate is taken for the next step of reaction. Add 1g of glycinamide hydrochloride to the filtrate obtained in the previous step, add 1.5mL triethylamine to dissolve glycinamide hydrochloride, stir at room temperature, react for 10h, then filter, and the filtered solid is the target product propylene Acylglycylglycylglycylamide monomer.

[0029] Dissolve 0.1 g of acryloylglycylglycylglycylamide monomer in 0.4 mL of dimethyl sulfoxide (DMSO) / water (dimethyl sulfoxide (DMSO) / water=1 / 10, V / V) under heating conditions In a mixed solvent, a solution was obtained. Add 0.003g thermal initiator ammonium persulfate to the solution, move the mixed solut...

Embodiment 3

[0032] Take 2g of acryloylglycine and disperse it in 270mL of dichloromethane. Keep stirring in an ice bath. After 20 minutes, add 6g of dicyclohexylcarbodiimide to the above solution. After stirring for 20 minutes, add 2.2g of N-hydroxyl Succinimide, reaction 6h. After the reaction is finished, the solid insoluble matter is filtered off, and the filtrate is taken for the next step of reaction. Add 0.75g glycinamide hydrochloride to the filtrate obtained in the previous step, add 0.9mL triethylamine to dissolve glycinamide hydrochloride, stir and react at room temperature for 12h, then filter, and the filtered solid is the target product propylene Amidylglycylamide monomer.

[0033] Dissolve 0.3g of acryloylglycylglycylglycylamide monomer in 0.7mL of dimethyl sulfoxide (DMSO) / water (dimethyl sulfoxide (DMSO) / water=1 / 6, V / V) In a mixed solvent, a solution was obtained. Add 0.009g of thermal initiator potassium persulfate to the solution, move the mixed solution into a mold a...

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Abstract

The invention provides a polyacrylamide glycyl glycinamide hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out reaction on N-acryloyl glycine, dicyclohexylcarbodiimide, N-hydroxysuccinimide and glycinamide hydrochloride to prepare an acryloyl glycyl glycinamide monomer; then dissolving the acryloyl glycyl glycinamide monomer into a dimethyl sulfoxide (DMSO) / water mixed solvent, initiating double bonds to generate free radical polymerization through a free radical initiator, and forming hydrogen bonds among amide groups to cause crosslinking, thus finally obtaining the polyacrylamide glycyl glycinamide hydrogel. The acryloyl glycyl glycine amide monomer is simple and convenient to synthesize and operate, the product purity is high, and the yield is high; the polyacrylamide glycyl glycinamide hydrogel can be obtained through hydrogen bond crosslinking, and an extra crosslinking agent does not need to be added.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a polyacryloylglycylglycylamide hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked polymer with a three-dimensional network structure that can swell in water and retain a large amount of water without being dissolved. Its most prominent feature is water absorption. Hydrogels have some characteristics similar to human tissue and have a wide range of applications in biomedicine. [0003] N-acryloylglycylamide contains two amide groups that form hydrogen bonding interactions between the molecules. Poly N-acryloylglycylamide has multiple hydrogen bonds between molecules and within molecules, and can be cross-linked by hydrogen bonds to obtain a hydrogel. The double hydrogen bond greatly enhances the mechanical strength of poly(N-acryloylglycylamide) hydrogels. [0004] Imitating the structure of N-acrylglycylglycylamide...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08F120/60C08L33/24
CPCC08F120/60C08J3/075C08J3/24C08J2333/24
Inventor 刘文广于婧杨建海
Owner TIANJIN UNIV