Cosmetic composition containing hyaluronic acid and/or derivative thereof as well as preparation method and application thereof
A cosmetic composition and a technology of hyaluronic acid are applied in the directions of skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., and can solve problems such as rough calculation of the rate of transdermal absorption of chemical substances
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preparation example Construction
[0053] In a specific embodiment, the preparation method of the cosmetic composition containing hyaluronic acid and / or its derivatives is provided, which includes:
[0054] Accurately weigh the required amount of hyaluronic acid or its salt, polyglutamic acid or its salt in a beaker;
[0055] Add one or more of butanediol, propylene glycol, 1,3-propanediol, 1,2-pentanediol, polyethylene glycol, dipropylene glycol, and hydrogenated lecithin in the required amount, stir well, and add an appropriate amount at 80℃~ 90 ℃ deionized water, use a stirrer to stir at high speed until the dispersion is uniform;
[0056] Cool down to 45°C;
[0057] Add the required amount of tetrahydromethyl pyrimidine carboxylic acid, acetylglucosamine, ergothioneine agaricus extract, aminobutyric acid, and brown rice fermentation extract;
[0058] Stir well.
[0059] In a third aspect the present application relates to the use of a cosmetic composition as described above.
[0060]In a specific embodi...
preparation example 1
[0066] ① Accurately weigh 0.5g of hydrolyzed sodium hyaluronate, 0.3g of 30wDa sodium hyaluronate, 0.1g of 140wDa sodium hyaluronate, 2g of sodium hyaluronate cross-linked polymer, 0.2g of acetylated sodium hyaluronate, and 0.3g of polyglutamine Put sodium polyglutamate 1, 0.08g sodium polyglutamate 2 into a beaker.
[0067] ② Add 3g of butanediol, 3g of 1,3-propanediol, 3g of 1,2-pentanediol, stir evenly, add 60g of deionized water at 80℃~90℃, and stir at high speed with a stirrer until uniformly dispersed;
[0068] ③ Cool down to 45°C, add 4 g of tetrahydromethyl pyrimidine carboxylic acid, 6 g of acetylglucosamine, 7 g of ergothioneine matsutake mushroom extract; 0.3 g of aminobutyric acid; 5 g of brown rice fermentation extract;
[0069] ④ Stir evenly, and use deionized water to make up 100g.
[0070] The difference between Examples 2-6 and Comparative Examples 1-4 lies in the contents of acetylglucosamine, hyaluronic acid, polyglutamic acid, tetrahydromethylpyrimidinecar...
preparation example
[0135] The preparation example has a significant improvement effect on the skin color starting from the second week of use, and shows a significant effect of brightening the skin color compared with the comparative example at 4w.
[0136] Table 6 Effect on skin brightness (ΔEab)
[0137] T0h T1w T2w T3w wxya Preparation Example 1 1.00 1.19 1.41 1.41 1.40 Comparative example 2 1.00 1.17 1.31 1.23 1.14 Comparative example 6 1.00 1.14 1.28 1.19 1.07
[0138] 2.4.5 Effect on skin texture
[0139] Compared with the comparison example, the preparation example can effectively reduce the skin texture area within four weeks after being applied.
[0140] Table 7 Effect on skin texture (%)
[0141] T0 T1w T2w T3w wxya Preparation Example 1 100 97.71 92.33 85.27 84.86 Comparative example 2 100 104.49 99.92 98.41 96.52 Comparative example 6 100 104.22 100.13 99.24 97.15
[0142] Co...
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