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Constructing and monitoring method for nanosecond pulse electric field ablation dynamic monitoring system

A nanosecond pulse and dynamic monitoring technology, applied in biochemical equipment and methods, stress-stimulated microbial growth methods, measuring devices, etc., can solve the problems of inability to accurately monitor surface discharge and surface burns of targeted tissues in real time, and achieve improvement Environmental noise and non-targeted thermal effects, enhanced electric field induction effects, and skin burn avoidance effects

Active Publication Date: 2021-04-23
CHINA UNIV OF PETROLEUM (EAST CHINA)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem that the existing technology cannot accurately monitor the target tissue surface discharge and surface burn during the ablation process in the prior art, the present invention provides a nanosecond pulsed electric field Construction method and system of dynamic monitoring device for ablation process, realizing dynamic monitoring of cell ablation effect during the implementation of nanosecond pulsed electric field

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  • Constructing and monitoring method for nanosecond pulse electric field ablation dynamic monitoring system
  • Constructing and monitoring method for nanosecond pulse electric field ablation dynamic monitoring system
  • Constructing and monitoring method for nanosecond pulse electric field ablation dynamic monitoring system

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Embodiment 1

[0072] A method for constructing a dynamic monitoring system for nanosecond pulsed electric field ablation process, the steps include:

[0073] 1) Build the insulating modified plate:

[0074] a) doping the polymer resin with ferroelectric ceramic nanoparticles;

[0075] b) wrapping the polar plate with the doped polymer resin and forming it;

[0076] c) performing material polarization on the formed pole plate;

[0077] 2) Set up a nanosecond pulse signal acquisition device,

[0078] a) Arranging insulating modified polar plates of different polarities on both sides of the target tissue, and connecting them to nanosecond high-voltage pulse generators respectively,

[0079] b) Arranging several ultrasonic probes around the target tissue, the acquisition plane of the ultrasonic probes is preferably perpendicular to the pulse direction of the bipolar plates,

[0080] c) connecting each ultrasonic probe with a low-noise amplifier and a signal acquisition device in turn,

[0...

Embodiment 2

[0120] In this embodiment, the method and steps described in Embodiment 1 are used to construct a dynamic monitoring system, and a finite element simulation model is established to perform nanosecond pulse electric field ablation and dynamic monitoring on the target tissue.

[0121] In order to study the relationship between the conductivity of the target tissue and the thermal function, a finite element simulation model was established, as shown in Fig. 2(a). Among them, the size of the external cube of the simulation model is 4*4*3.6cm, and the interior is four cylinders with a radius of 0.2cm and a height of 3.6cm. The simulation results are shown in Figure 2(b)-(c). From the above simulation results, it can be seen that as the conductivity of the target tissue increases, the thermal function generated by it gradually decreases, and the ultrasonic signal generated by the thermal expansion of the tissue will also decrease, so that the target tissue can be observed through th...

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Abstract

The invention discloses a constructing and monitoring method for a nanosecond pulse electric field ablation dynamic monitoring system, and belongs to the field of pulse radiation imaging monitoring. A polar plate is wrapped by polymer resin doped with ferroelectric ceramic nanoparticles; through the induction in target tissue to produce an electric field, target tissue cells can be ablated by nanosecond pulse, so that electric field induction effects can be enhanced; the direct contact of the polar plate and the air or the target tissue can be prevented, and the problems of surface discharge and burn of normal tissue can be avoided; and an ultrasonic probe array is adopted to dynamically monitor the ultrasonic signals excited by the target tissue, the ultrasonic signals can reflect the conductivity distribution information of the target tissue, so that the changes of the conductivity of the target tissue can be observed so as to realize the dynamic monitoring of pulse ablation effects.

Description

technical field [0001] The invention belongs to the field of pulse radiation imaging monitoring, and in particular relates to a construction and monitoring method of a dynamic monitoring system for nanosecond pulse electric field ablation process. Background technique [0002] In bioengineering, cell tissue culture is the key link, that is, placing cells, tissues or organs in an in vitro environment similar to that of a living body to promote their survival, growth and proliferation, and even induce their late differentiation and transformation. However, during the cultivation process, despite strict disinfection and sterilization operations, it is inevitable that other impurities or heterogeneous bacteria will be introduced, which will have a serious impact on the cell growth environment in the tissue. Even in high-level biological laboratories, abnormal mutations and uncontrolled division of cells are unavoidable. For such cultured tissues containing non-target cell popul...

Claims

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Application Information

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IPC IPC(8): C12M1/42C12M1/34C12M1/00C12Q1/02G01N27/04
CPCC12M41/46C12M35/02G01N33/5005G01N27/04
Inventor 郭亮王祥业姜文聪邢兰昌李粟曾彩虹
Owner CHINA UNIV OF PETROLEUM (EAST CHINA)