Application of vitamin E compound
A vitamin and compound technology, applied in the field of preparing medicines for relieving bone marrow suppression or alleviating hemolysis, can solve the problems of anemia, allergic reaction, hemolytic toxicity, bone marrow suppression, etc., to reduce the growth inhibitory effect of bone marrow cells and improve the anti-tumor effect , reducing the effect of hemolytic disease
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Embodiment 1
[0077] Prescription 1 (VE nano-preparation)
[0078]
[0079] Prescription 2 (VE nano-formulation loaded with docetaxel)
[0080]
[0081] Prescription 3: (DTX nano preparation DTX-NS)
[0082]
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Embodiment 2
[0139] prescription
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[0141] Preparation:
[0142] (1) Oil phase: at 20-40°C, mix paclitaxel, egg yolk lecithin, vitamin E, medium chain triglycerides, oleic acid and absolute ethanol and stir until clear, evaporate the ethanol in vacuo to obtain oil phase;
[0143] (2) Water phase: add sucrose to water for injection, stir until completely dissolved, and filter with a 0.22 μm microporous membrane to obtain the water phase;
[0144] (3) Colostrum: first preheat the water phase and the oil phase to 50-70°C, then use a high-speed disperser to slowly add the water phase to the oil phase under the shearing and stirring of 5000-20000rpm, and after it is completely added, Continuous shearing at 15000rpm for 20 minutes to obtain colostrum;
[0145] (4) Final milk: cool the colostrum to room temperature, then transfer it to a high-pressure homogenizer, and homogenize it 4 times at 25-45°C and 1000 bar;
[0146] (5) Filtration and subpackaging: use a 0.22 μm microporous ...
Embodiment 3
[0152] prescription
[0153]
[0154] Preparation:
[0155] (1) Oil phase: under the condition of 20-40℃, mix tartaric acid, egg yolk lecithin, vitamin E, medium-chain triglycerides, oleic acid and absolute ethanol and stir until clear, evaporate ethanol in vacuum, that is get oily phase;
[0156] (2) Water phase: add sucrose to water for injection, stir until completely dissolved, and filter with a 0.22 μm microporous membrane to obtain the water phase;
[0157] (3) Colostrum: first preheat the water phase and the oil phase to 50-70°C, then use a high-speed disperser to slowly add the water phase to the oil phase under the shearing and stirring of 5000-20000rpm, and after it is completely added, Continuous shearing at 15000rpm for 30 minutes to obtain colostrum;
[0158] (4) Final milk: cool the colostrum to room temperature, then transfer it to a high-pressure homogenizer, and homogenize it 4 times at 25-45°C and 1200 bar;
[0159] (5) Filtration and subpackaging: use...
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