Application of vitamin E compound

A vitamin and compound technology, applied in the field of preparing medicines for relieving bone marrow suppression or alleviating hemolysis, can solve the problems of anemia, allergic reaction, hemolytic toxicity, bone marrow suppression, etc., to reduce the growth inhibitory effect of bone marrow cells and improve the anti-tumor effect , reducing the effect of hemolytic disease

Pending Publication Date: 2021-04-27
HUIYU HEALTH HANGZHOU PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, normal tissues are also often damaged by elevated levels of oxidative stress
[0004] Some chemotherapeutic drugs can also cause hemolytic toxicity, bone marrow suppression, anemia and allergic reactions, etc.

Method used

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  • Application of vitamin E compound
  • Application of vitamin E compound
  • Application of vitamin E compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Prescription 1 (VE nano-preparation)

[0078]

[0079] Prescription 2 (VE nano-formulation loaded with docetaxel)

[0080]

[0081] Prescription 3: (DTX nano preparation DTX-NS)

[0082]

[0083]

Embodiment 2

[0139] prescription

[0140]

[0141] Preparation:

[0142] (1) Oil phase: at 20-40°C, mix paclitaxel, egg yolk lecithin, vitamin E, medium chain triglycerides, oleic acid and absolute ethanol and stir until clear, evaporate the ethanol in vacuo to obtain oil phase;

[0143] (2) Water phase: add sucrose to water for injection, stir until completely dissolved, and filter with a 0.22 μm microporous membrane to obtain the water phase;

[0144] (3) Colostrum: first preheat the water phase and the oil phase to 50-70°C, then use a high-speed disperser to slowly add the water phase to the oil phase under the shearing and stirring of 5000-20000rpm, and after it is completely added, Continuous shearing at 15000rpm for 20 minutes to obtain colostrum;

[0145] (4) Final milk: cool the colostrum to room temperature, then transfer it to a high-pressure homogenizer, and homogenize it 4 times at 25-45°C and 1000 bar;

[0146] (5) Filtration and subpackaging: use a 0.22 μm microporous ...

Embodiment 3

[0152] prescription

[0153]

[0154] Preparation:

[0155] (1) Oil phase: under the condition of 20-40℃, mix tartaric acid, egg yolk lecithin, vitamin E, medium-chain triglycerides, oleic acid and absolute ethanol and stir until clear, evaporate ethanol in vacuum, that is get oily phase;

[0156] (2) Water phase: add sucrose to water for injection, stir until completely dissolved, and filter with a 0.22 μm microporous membrane to obtain the water phase;

[0157] (3) Colostrum: first preheat the water phase and the oil phase to 50-70°C, then use a high-speed disperser to slowly add the water phase to the oil phase under the shearing and stirring of 5000-20000rpm, and after it is completely added, Continuous shearing at 15000rpm for 30 minutes to obtain colostrum;

[0158] (4) Final milk: cool the colostrum to room temperature, then transfer it to a high-pressure homogenizer, and homogenize it 4 times at 25-45°C and 1200 bar;

[0159] (5) Filtration and subpackaging: use...

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Abstract

The invention relates to an application of a vitamin E compound in preparation of a medicine for reducing the oxidative stress level caused by an anti-tumor medicine, an application of the vitamin E compound and the anti-tumor medicine in preparation of a medicine for improving immunity and an application of the vitamin E compound in preparation of a medicine for relieving myelosuppression caused by the anti-tumor medicine or relieving hemolysis diseases caused by the anti-tumor medicine.

Description

technical field [0001] The present invention relates to the use of vitamin E compounds in the preparation of medicines for down-regulating the level of oxidative stress caused by medicines, the use of vitamin E compounds in the preparation of medicines for improving immunity, and the preparation of medicines for alleviating myelosuppression or hemolysis. Uses in medicine. Background technique [0002] Many chemotherapeutic drugs have been proved to have strong anti-tumor activity in clinic. However, obvious toxic and side effects often appear during the treatment, which seriously restricts its clinical application. [0003] Reactive oxygen species (ROS) are highly reactive ions and free radicals, including singlet oxygen, superoxide radicals, hydroxyl radicals, and peroxides, which play imperative roles in many physiological processes. At lower concentrations, ROS serve as important second messengers regulating cell signaling, adhesion, migration, and homeostasis. High le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/355A61K45/06A61K31/337A61K31/475A61K31/4745A61K9/107A61P35/00A61P39/06A61P37/04A61P7/00
CPCA61K31/355A61K45/06A61K31/337A61K31/475A61K31/4745A61K9/1075A61K9/0019A61P35/00A61P39/06A61P37/04A61P7/00A61K9/107A61K9/10
Inventor 李青坡姜新东金召磊邱伟根
Owner HUIYU HEALTH HANGZHOU PHARM TECH CO LTD
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