Application of inonotus obliquus in preparation of medicine for resisting ventricular remodeling

A ventricular remodeling and Chaga technology, which is applied in the field of medicine, can solve the problems of not alleviating the progression of the disease course, aggravating atrioventricular conduction, electrolyte disturbance, etc., and achieves the effects of huge social and economic benefits, abundant raw material sources, and easy popularization and application.

Inactive Publication Date: 2021-04-30
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Beta receptor blockers (Mcmurray J J, Adamopoulos S, Anker S D, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The TaskForce for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association (HFA) of the ESC[J].Eur J Heart Fail.2012,14(8):803-869), diuretics, angiotensin converting enzyme inhibitors, for Although the representative "Golden Triangle" therapy can significantly improve the clinical symptoms of patients with heart failure, there are toxic side effects such as inducing bronchial asthma, aggravating atrioventricular block, causing irritating dry cough and electrolyte imbalance.
Moreover, this therapy is mainly aimed at patients with middle and advanced heart failure, and only improves their clinical symptoms, but does not alleviate the progression of the disease, let alone prevent ventricular remodeling and reverse the remodeled ventricle, and cannot prolong the life of patients with moderate and severe heart failure.
However, there is no relevant report on the effect of IO and its monomeric components on ventricular remodeling.

Method used

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  • Application of inonotus obliquus in preparation of medicine for resisting ventricular remodeling
  • Application of inonotus obliquus in preparation of medicine for resisting ventricular remodeling
  • Application of inonotus obliquus in preparation of medicine for resisting ventricular remodeling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1, the preparation of chaga extract

[0077] 8 kg of Chaga mycelia medicinal materials obtained were first crushed into coarse powder using a pulverizer, and then 10 times the sample mass volume of ethanol aqueous solution (ethanol:water=95:5, v / v) was heated and refluxed for extraction, and the extraction was repeated 3 times ( The extraction time is 2h), and the refluxing extracts combined for 3 times are filtered through gauze. Utilize rotary evaporator to concentrate extract, obtain ethanol extract (10 ethanol total extract) 240g altogether, all extracts are sealed and preserved in-20 ℃ of refrigerator for subsequent use.

Embodiment 2

[0078] Example 2, the separation and preparation of monomers in chaga extract

[0079] 10 total ethanol extracts (220g) were added with an appropriate amount of water to suspend, followed by an equal volume of chloroform for extraction, and extracted 3 times to obtain a chloroform layer extract (45.5g). Chloroform layer extract (40g) was purified by silica gel column chromatography (1500g), eluted with petroleum ether / ethyl acetate, and the elution gradient was 25:1, 20:1, 15:1, 10:1, 5: 1, 2:1, 1:1, pure methanol (v / v), each gradient eluted with 1.5 column bed volumes. Through thin-layer chromatography and ethanol sulfate chromogen for color development, the same components were combined to obtain 12 fractions (1-12). Fractions 3 and 4 were recrystallized at room temperature to obtain lanosterol (2.0g), 3β-hydroxylanoster-8, 24-diene-21-aldehyde (3.0g); fractions 5-6 were prepared in petroleum ether-ethyl acetate The mixed solution (10:1, 5:1, v / v) was recrystallized at roo...

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Abstract

The invention discloses an application of inonotus obliquus or an inonotus obliquus extract in preparation of a medicine for resisting ventricular remodeling. Two clinically related ventricular remodeling disease models, namely isoprenaline (ISO) subcutaneous injection induced mouse ventricular remodeling and aortic arch constriction (TAC) induced mouse ventricular remodeling, are adopted. The experiments prove that oral gavage of inonotus obliquus can obviously inhibit occurrence and development of ISO subcutaneous injection and TAC operation induced mouse ventricular remodeling, and it is clear that effective active monomer components in inonotus obliquus triterpenes comprise lanosterol, inonotus obliquus alcohol, 3 beta-hydroxyl lanostane-8, 24-diene-21-aldehyde and 3 beta-hydroxyl lanostane-8, 24-diene-21-acid. The product can be used for preventing and treating ventricular remodeling of patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of chaga in the preparation of anti-ventricular remodeling drugs. Background technique [0002] my country is a country with a high incidence of hypertension and coronary heart disease. According to the World Health Organization database, the prevalence of hypertension in the Chinese population is increasing year by year. The long-term pressure load caused by diseases such as hypertension and coronary heart disease is the most common inducing factor of chronic heart failure, and its morbidity and mortality are extremely high. The five-year survival rate is similar to that of malignant tumors, and it is the terminal of various cardiovascular diseases. stage (Zhonghua Xin Xue Guan Bing Za Zhi. 2015; 43(12):1018–21). The pathological basis of heart failure is ventricular remodeling, including myocardial hypertrophy and myocardial fibrosis. Among them, myocardia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P9/00
CPCA61K36/07A61P9/00
Inventor 祁荣丘鹰昆古丽妮尕尔·安外尔徐向群
Owner PEKING UNIV
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